Rat E3 ubiquitin-protein ligase parkin, PARK2 ELISA Kit | MyBioSource MBS9325400 product information

product summary

company name :

MyBioSource

product type :

ELISA/assay

product name :

Rat E3 ubiquitin-protein ligase parkin, PARK2 ELISA Kit

catalog :

MBS9325400

quantity :

48-Strip-Wells

price :

470 USD

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS9325400

products type :

ELISA Kit

products full name :

Rat E3 ubiquitin-protein ligase parkin, PARK2 ELISA Kit

products short name :

[Parkinson disease (autosomal recessive, juvenile) 2, parkin]

products name syn :

[Rat E3 ubiquitin-protein ligase parkin (PARK2) ELISA kit; AR-JP; LPRS2; PDJ; PRKN; E3 ubiquitin ligase; parkin; parkin 2; Parkinson disease (autosomal recessive; juvenile) 2; parkin]

other names :

[E3 ubiquitin-protein ligase parkin; E3 ubiquitin-protein ligase parkin; E3 ubiquitin-protein ligase parkin; parkin variant SV5DEL; Parkinson disease (autosomal recessive, juvenile) 2, parkin; parkinson protein 2, E3 ubiquitin protein ligase]

products gene name :

[PARK2]

other gene names :

[Park2; Park2; Park; Prkn; Prkn]

uniprot entry name :

PRKN2_RAT

reactivity :

Rat

storage stability :

Store all reagents at 2-8 degree C

other info1 :

Samples: Rat Body Fluids And Tissue Homogenates. Assay Type: Quantitative Sandwich. Detection Range: 0.625ng/ml-20ng/ml. Sensitivity: 0.1ng/ml.

other info2 :

Intra-assay Precision: Intra-assay CV (%) is less than 15%. Inter-assay Precision: Inter-assay CV (%) is less than 15%. [CV(%) = SD/mean ×100]. All CV% should be compared by concentration, not compared by OD values.

products description :

Background/Introduction: This Quantitative Sandwich ELISA kit is for lab reagent/research use only, not for drug, household, therapeutic or diagnostic applications! This kit is intended to be used for determine the level of PARG (hereafter termed "analyte") in undiluted original Rat body fluids and tissue homogenates. This kit is NOT suitable for assaying non-biological sources of substances.

ncbi gi num :

11464987

ncbi acc num :

NP_064478.1

ncbi gb acc num :

NM_020093.1

uniprot acc num :

Q9JK66

ncbi mol weight :

51,709 Da

ncbi pathways :

Parkinson's Disease Pathway (83490); Protein Processing In Endoplasmic Reticulum Pathway (167310); Protein Processing In Endoplasmic Reticulum Pathway (167190); Ubiquitin Mediated Proteolysis Pathway (83448); Ubiquitin Mediated Proteolysis Pathway (466)

ncbi summary :

localized to the cytoplasm in neurons of many regions of the brain; has N-terminal ubiquitin and ring-IBR-ring finger domains [RGD, Feb 2006]

uniprot summary :

PARK2: Functions within a multiprotein E3 ubiquitin ligase complex, catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins, such as BCL2, SYT11, CCNE1, GPR37, RHOT1/MIRO1, MFN1, MFN2, STUB1, SNCAIP, SEPT5, TOMM20, USP30, ZNF746 and AIMP2. Mediates monoubiquitination as well as Lys-6 , Lys-11 , Lys-48 -linked and Lys-63 -linked polyubiquitination of substrates depending on the context. Participates in the removal and/or detoxification of abnormally folded or damaged protein by mediating Lys-63 -linked polyubiquitination of misfolded proteins such as PARK7: Lys-63 -linked polyubiquitinated misfolded proteins are then recognized by HDAC6, leading to their recruitment to aggresomes, followed by degradation. Mediates Lys-63 -linked polyubiquitination of a 22 kDa O-linked glycosylated isoform of SNCAIP, possibly playing a role in Lewy-body formation. Mediates monoubiquitination of BCL2, thereby acting as a positive regulator of autophagy. Promotes the autophagic degradation of dysfunctional depolarized mitochondria (mitophagy) by promoting the ubiquitination of mitochondrial proteins such as TOMM20, RHOT1/MIRO1 and USP30. Preferentially assembles Lys-6 -, Lys-11 - and Lys-63 -linked polyubiquitin chains following mitochondrial damage, leading to mitophagy. Mediates Lys-48 -linked polyubiquitination of ZNF746, followed by degradation of ZNF746 by the proteasome; possibly playing a role in the regulation of neuron death. Limits the production of reactive oxygen species (ROS). Regulates cyclin-E during neuronal apoptosis. In collaboration with CHPF isoform 2, may enhance cell viability and protect cells from oxidative stress. Independently of its ubiquitin ligase activity, protects from apoptosis by the transcriptional repression of p53/TP53. May protect neurons against alpha synuclein toxicity, proteasomal dysfunction, GPR37 accumulation, and kainate-induced excitotoxicity. May play a role in controlling neurotransmitter trafficking at the presynaptic terminal and in calcium-dependent exocytosis. May represent a tumor suppressor gene. Protein type: Ubiquitin ligase; Ubiquitin conjugating system; EC 6.3.2.19; EC 6.3.2.-; Ligase

size1 :

48-Strip-Wells

price1 :

470 USD

size2 :

96-Strip-Wells

price2 :

680

size3 :

5x96-Strip-Wells

price3 :

3100

size4 :

10x96-Strip-Wells

price4 :

6095

more info or order :

MyBioSource product webpage