Human E3 ubiquitin-protein ligase TRIM21, TRIM21 ELISA Kit | MyBioSource MBS9325289 product information

product summary

company name :

MyBioSource

product type :

ELISA/assay

product name :

Human E3 ubiquitin-protein ligase TRIM21, TRIM21 ELISA Kit

catalog :

MBS9325289

quantity :

48-Strip-Wells

price :

435 USD

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS9325289

products type :

ELISA Kit

products full name :

Human E3 ubiquitin-protein ligase TRIM21, TRIM21 ELISA Kit

products short name :

tripartite motif-containing 21

products name syn :

Human E3 ubiquitin-protein ligase TRIM21 (TRIM21) ELISA kit; RNF81; RO52; SSA; SSA1; Sicca syndrome antigen A; Sjogren syndrome antigen A1 (52kDa; ribonucleoprotein autoantigen SS-A/Ro) ; tripartite motif protein 21; tripartite motif-containing 21

other names :

E3 ubiquitin-protein ligase TRIM21; E3 ubiquitin-protein ligase TRIM21; E3 ubiquitin-protein ligase TRIM21; SS-A; ro(SS-A); 52 kDa Ro protein; RING finger protein 81; Sicca syndrome antigen A; tripartite motif-containing 21; sjoegren syndrome type A antigen; tripartite motif-containing protein 21; 52 kDa ribonucleoprotein autoantigen Ro/SS-A; Sjogren syndrome antigen A1 (52kDa, ribonucleoprotein autoantigen SS-A/Ro); tripartite motif containing 21; 52 kDa Ro protein; 52 kDa ribonucleoprotein autoantigen Ro/SS-A; RING finger protein 81; Ro(SS-A); Sjoegren syndrome type A antigen; SS-A; Tripartite motif-containing protein 21

products gene name :

TRIM21

other gene names :

TRIM21; TRIM21; SSA; RO52; SSA1; RNF81; Ro/SSA; RNF81; RO52; SSA1; SS-A

uniprot entry name :

RO52_HUMAN

reactivity :

Human

storage stability :

Store all reagents at 2-8 degree C

ncbi gi num :

15208660

ncbi acc num :

NP_003132.2

ncbi gb acc num :

NM_003141.3

uniprot acc num :

P19474

ncbi mol weight :

54,170 Da

ncbi pathways :

Adaptive Immune System Pathway (366160); Antigen Processing: Ubiquitination Proteasome Degradation Pathway (366162); Class I MHC Mediated Antigen Processing Presentation Pathway (366161); Immune System Pathway (106386); Systemic Lupus Erythematosus Pathway (83122); Systemic Lupus Erythematosus Pathway (534)

ncbi summary :

This gene encodes a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. The encoded protein is part of the RoSSA ribonucleoprotein, which includes a single polypeptide and one of four small RNA molecules. The RoSSA particle localizes to both the cytoplasm and the nucleus. RoSSA interacts with autoantigens in patients with Sjogren syndrome and systemic lupus erythematosus. Alternatively spliced transcript variants for this gene have been described but the full-length nature of only one has been determined. [provided by RefSeq, Jul 2008]

uniprot summary :

TRIM21: E3 ubiquitin-protein ligase whose activity is dependent on E2 enzymes, UBE2D1, UBE2D2, UBE2E1 and UBE2E2. Forms a ubiquitin ligase complex in cooperation with the E2 UBE2D2 that is used not only for the ubiquitination of USP4 and IKBKB but also for its self-ubiquitination. Component of cullin-RING-based SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complexes such as SCF(SKP2)-like complexes. A TRIM21-containing SCF(SKP2)- like complex is shown to mediate ubiquitination of CDKN1B ( Thr- 187 phosphorylated-form), thereby promoting its degradation by the proteasome. Monoubiquitinates IKBKB that will negatively regulates Tax-induced NF-kappa-B signaling. Negatively regulates IFN-beta production post-pathogen recognition by polyubiquitin- mediated degradation of IRF3. Mediates the ubiquitin-mediated proteasomal degradation of IgG1 heavy chain, which is linked to the VCP-mediated ER-associated degradation (ERAD) pathway. Promotes IRF8 ubiquitination, which enhanced the ability of IRF8 to stimulate cytokine genes transcription in macrophages. Plays a role in the regulation of the cell cycle progression. Enhances the decapping activity of DCP2. Exists as a ribonucleoprotein particle present in all mammalian cells studied and composed of a single polypeptide and one of four small RNA molecules. At least two isoforms are present in nucleated and red blood cells, and tissue specific differences in RO/SSA proteins have been identified. The common feature of these proteins is their ability to bind HY RNAs.2. Belongs to the TRIM/RBCC family. 2 isoforms of the human protein are produced by alternative splicing. Protein type: Ubiquitin ligase; EC 6.3.2.-; Ubiquitin conjugating system; Ligase. Chromosomal Location of Human Ortholog: 11p15.5. Cellular Component: nucleoplasm; cytoplasm; SCF ubiquitin ligase complex; ribonucleoprotein complex; nucleus; cytosol. Molecular Function: identical protein binding; protein binding; DNA binding; zinc ion binding; RNA binding; ubiquitin-protein ligase activity; ligase activity. Biological Process: protein monoubiquitination; regulation of interferon type I production; protein autoubiquitination; protein polyubiquitination; protein destabilization; cytokine and chemokine mediated signaling pathway; positive regulation of cell cycle; protein ubiquitination; cell cycle; negative regulation of viral transcription; positive regulation of virion penetration into host cell; inhibition of NF-kappaB transcription factor; positive regulation of interferon type I production; innate immune response; positive regulation of transcription factor activity

size1 :

48-Strip-Wells

price1 :

435 USD

size2 :

96-Strip-Wells

price2 :

600

more info or order :

MyBioSource product webpage