catalog number :
MBS9324957
products type :
ELISA Kit
products full name :
Rat Monocarboxylate transporter 1, SLC16A1 ELISA Kit
products short name :
solute carrier family 16, member 1 (monocarboxylic acid transporter 1)
products name syn :
Rat Monocarboxylate transporter 1 (SLC16A1) ELISA kit; FLJ36745; HHF7; MCT; MCT1; MGC44475; monocarboxylate transporter 1; solute carrier family 16 (monocarboxylic acid transporters); member 1; solute carrier family 16; member 1; solute carrier family 16; member 1 (monocarboxylic acid transporter 1)
other names :
monocarboxylate transporter 1; Monocarboxylate transporter 1; monocarboxylate transporter 1; MCT 1; solute carrier 16 (monocarboxylic acid transporter), member 1; solute carrier family 16 (monocarboxylic acid transporters), member 1; solute carrier family 16, member 1 (monocarboxylic acid transporter 1); solute carrier family 16 (monocarboxylate transporter), member 1; Solute carrier family 16 member 1
products gene name :
SLC16A1
other gene names :
Slc16a1; Slc16a1; MCT1; RNMCT1; RATMCT1; Mct1; MCT 1
uniprot entry name :
MOT1_RAT
ncbi acc num :
NP_036848.1
ncbi gb acc num :
NM_012716.2
ncbi mol weight :
53,238 Da
ncbi pathways :
Basigin Interactions Pathway 573934!!Cell Surface Interactions At The Vascular Wall Pathway 573932!!Hemostasis Pathway 573899!!Metabolism Pathway 573935!!Proton-coupled Monocarboxylate Transport Pathway 574496!!Pyruvate Metabolism Pathway 574027!!Pyruvate Metabolism And Citric Acid (TCA) Cycle Pathway 574026!!SLC-mediated Transmembrane Transport Pathway 574477!!The Citric Acid (TCA) Cycle And Respiratory Electron Transport Pathway 574025!!Transmembrane Transport Of Small Molecules Pathway 574473
ncbi summary :
transports lactic acid and other monocarboxylic acids [RGD, Feb 2006]
uniprot summary :
Function: Proton-coupled monocarboxylate transporter. Catalyzes the rapid transport across the plasma membrane of many monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and the ketone bodies acetoacetate, beta-hydroxybutyrate and acetate. Depending on the tissue and on cicumstances, mediates the import or export of lactic acid and ketone bodies. Required for normal nutrient assimilation, increase of white adipose tissue and body weight gain when on a high-fat diet. Plays a role in cellular responses to a high-fat diet by modulating the cellular levels of lactate and pyruvate, small molecules that contribute to the regulation of central metabolic pathways and insulin secretion, with concomitant effects on plasma insulin levels and blood glucose homeostasis.5 PublicationsManual assertion based on experiment in:Ref.1. Enzyme regulation: Inhibited by stilbene disulfonates, such as di-isothiocyanostilbene disulfonate(DIDS), a cross-linking reagent that forms covalent linkages with lysine groups.1 PublicationManual assertion based on experiment in:Ref.9