catalog number :
MBS9324933
products type :
ELISA Kit
products full name :
Rat Gephyrin [Includes: Molybdopterin adenylyltransferase, GPHN ELISA Kit
products short name :
[gephyrin]
products name syn :
[Rat Gephyrin [Includes: Molybdopterin adenylyltransferase (GPHN) ELISA kit; GEPH; GPH; GPHRYN; KIAA1385; ; gephyrin]
other names :
[gephyrin; Gephyrin; gephyrin; gephyrin isoform; putative glycine receptor-tubulin linker protein; gephyrin; Putative glycine receptor-tubulin linker proteinIncluding the following 2 domains:Molybdopterin adenylyltransferase (EC:2.7.7.75); MPT adenylyltransferaseAlternative name(s):Domain G]
products gene name :
[GPHN]
other gene names :
[Gphn; Gphn; Geph; Gph; MPT adenylyltransferase; MPT Mo-transferase]
uniprot entry name :
GEPH_RAT
specificity :
No significant cross-reactivity or interference between this analyte and analogues is observed.
storage stability :
Store all reagents at 2-8 degree C
other info1 :
Samples: Undiluted original Rat body fluids, tissue homogenates, secretions or feces samples. This kit is NOT suitable for assaying non-biological sources of substances. Assay Type: Sandwich. Detection Range: 0.625 ng/ml - 20 ng/ml. Sensitivity: 0.1 ng/ml.
other info2 :
Intra-assay Precision: Intra-assay CV (%) is less than 15%. Inter-assay Precision: Inter-assay CV (%) is less than 15%. [CV(%) = SD/mean ×100].
products description :
Background/Introduction: This Quantitative Sandwich ELISA kit is only for in vitro research use only, not for drug, household, therapeutic or diagnostic applications! This kit is intended to be used for determination the level of GPHN (hereafter termed "analyte") in undiluted original Rat body fluids, tissue homogenates, secretions or feces samples. This kit is NOT suitable for assaying non-biological sources of substances.
ncbi acc num :
NP_074056.2
ncbi gb acc num :
NM_022865.3
ncbi mol weight :
83,266 Da
ncbi pathways :
GABAergic Synapse Pathway (377244); GABAergic Synapse Pathway (377129)
ncbi summary :
plays a role in molybdenum cofactor biosynthesis; may play a role in membrane protein-cytoskeleton interactions [RGD, Feb 2006]
uniprot summary :
gephyrin: Microtubule-associated protein involved in membrane protein-cytoskeleton interactions. It is thought to anchor the inhibitory glycine receptor (GLYR) to subsynaptic microtubules. Catalyzes two steps in the biosynthesis of the molybdenum cofactor. In the first step, molybdopterin is adenylated. Subsequently, molybdate is inserted into adenylated molybdopterin and AMP is released. Homotrimer. Interacts with GABARAP. Inhibited by copper and tungsten. 2 isoforms of the human protein are produced by alternative splicing. Protein type: Adaptor/scaffold; EC 2.10.1.1; EC 2.7.7.75. Cellular Component: postsynaptic membrane; cytoskeleton; cytoplasm; synapse; intracellular; cell junction. Molecular Function: protein binding, bridging; tubulin binding; protein binding; protein homodimerization activity; metal ion binding; protein complex scaffold; ATP binding; receptor binding. Biological Process: establishment of protein localization; molybdenum incorporation into molybdenum-molybdopterin complex; synaptogenesis; establishment of synaptic specificity at neuromuscular junction; Mo-molybdopterin cofactor biosynthetic process; protein homooligomerization; protein targeting
size4 :
10x96-Strip-Wells