catalog number :
MBS9324719
products type :
ELISA Kit
products full name :
Bovine C-C chemokine receptor type 11, CCRL1 ELISA Kit
products short name :
chemokine (C-C motif) receptor-like 1
products name syn :
Bovine C-C chemokine receptor type 11 (CCRL1) ELISA kit; CC-CKR-11; CCBP2; CCR10; CCR11; CCX-CKR; CKR-11; PPR1; VSHK1; C-C chemokine receptor type 11; chemocentryx chemokine receptor; chemokine; cc motif; receptor-like protein 1; orphan seven-transmembrane r; chemokine (C-C motif) receptor-like 1
other names :
atypical chemokine receptor 4; Atypical chemokine receptor 4; atypical chemokine receptor 4; CCR-11; CC-CKR-11; C-C CKR-11; CC chemokine receptor-like 1; C-C chemokine receptor type 11; putative gustatory receptor type B; chemokine (C-C motif) receptor-like 1<; C-C chemokine receptor type 11; C-C CKR-11; CC-CKR-11; CCR-11; CC chemokine receptor-like 1; Protein PPR1; Putative gustatory receptor type B
products gene name :
CCRL1
other gene names :
ACKR4; ACKR4; CCRL1; CCR11; CCRL1; C-C CKR-11; CC-CKR-11; CCR-11
uniprot entry name :
ACKR4_BOVIN
ncbi acc num :
NP_776690.1
ncbi gb acc num :
NM_174265.2
ncbi mol weight :
40,008 Da
ncbi pathways :
Chemokine Receptors Bind Chemokines Pathway 636622!!Class A/1 (Rhodopsin-like Receptors) Pathway 636620!!GPCR Ligand Binding Pathway 636619!!Peptide Ligand-binding Receptors Pathway 636621!!Signal Transduction Pathway 636469!!Signaling By GPCR Pathway 636618
uniprot summary :
Function: Atypical chemokine receptor that controls chemokine levels and localization via high-affinity chemokine binding that is uncoupled from classic ligand-driven signal transduction cascades, resulting instead in chemokine sequestration, degradation, or transcytosis. Also known as interceptor (internalizing receptor) or chemokine-scavenging receptor or chemokine decoy receptor. Acts as a receptor for chemokines CCL2, CCL8, CCL13, CCL19, CCL21 and CCL25. Chemokine-binding does not activate G-protein-mediated signal transduction but instead induces beta-arrestin recruitment, leading to ligand internalization. Plays an important role in controlling the migration of immune and cancer cells that express chemokine receptors CCR7 and CCR9, by reducing the availability of CCL19, CCL21, and CCL25 through internalization. Negatively regulates CXCR3-induced chemotaxis. Regulates T-cell development in the thymus