Mouse Tight junction protein ZO-1, TJP1 ELISA Kit | MyBioSource MBS9324491 product information

product summary

company name :

MyBioSource

product type :

ELISA/assay

product name :

Mouse Tight junction protein ZO-1, TJP1 ELISA Kit

catalog :

MBS9324491

quantity :

48-Strip-Wells

price :

435 USD

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS9324491

products type :

ELISA Kit

products full name :

Mouse Tight junction protein ZO-1, TJP1 ELISA Kit

products short name :

tight junction protein 1 (zona occludens 1)

products name syn :

Mouse Tight junction protein ZO-1 (TJP1) ELISA kit; DKFZp686M05161; MGC133289; ZO-1; tight junction protein 1; tight junction protein ZO-1; zona occludens 1; zonula occludens 1 protein; tight junction protein 1 (zona occludens 1)

other names :

tight junction protein ZO-1 isoform 1; Tight junction protein ZO-1; tight junction protein ZO-1; zona occludens protein 1; zonula occludens protein 1; tight junction protein 1; Tight junction protein 1; Zona occludens protein 1; Zonula occludens protein 1

products gene name :

TJP1

other gene names :

Tjp1; Tjp1; ZO1; Zo1

uniprot entry name :

ZO1_MOUSE

reactivity :

Mouse

specificity :

No significant cross-reactivity or interference between this analyte and analogues is observed.

storage stability :

Store all reagents at 2-8 degree C

other info1 :

Samples: Undiluted original Mouse body fluids, tissue homogenates, secretions or feces samples. This kit is NOT suitable for assaying non-biological sources of substances. Assay Type: Sandwich. Detection Range: 0.25 ng/ml - 8 ng/ml. Sensitivity: 0.1 ng/ml.

other info2 :

Intra-assay Precision: Intra-assay CV (%) is less than 15%. Inter-assay Precision: Inter-assay CV (%) is less than 15%. [CV(%) = SD/mean ×100].

products description :

Background/Introduction: This Quantitative Sandwich ELISA kit is only for in vitro research use only, not for drug, household, therapeutic or diagnostic applications! This kit is intended to be used for determination the level of TJP1 (hereafter termed "analyte") in undiluted original Mouse body fluids, tissue homogenates, secretions or feces samples. This kit is NOT suitable for assaying non-biological sources of substances.

ncbi gi num :

254675277

ncbi acc num :

NP_033412.2

ncbi gb acc num :

NM_009386.2

uniprot acc num :

P39447

ncbi mol weight :

194,742 Da

ncbi pathways :

Adherens Junction Pathway (83267); Adherens Junction Pathway (481); Gap Junction Pathway (83269); Gap Junction Pathway (483); Gap Junction Trafficking And Regulation Pathway (574575); Membrane Trafficking Pathway (574566); Regulation Of Gap Junction Activity Pathway (574584); Salmonella Infection Pathway (375174); Salmonella Infection Pathway (375149); Tight Junction Pathway (83268)

uniprot summary :

ZO1: a scaffolding protein of the MAGUK (membrane-associated guanylate kinase) family associated with tight junctions (TJ). May mediate dynamic changes in the composition of TJs. The N-terminal may be involved in transducing a signal required for tight junction assembly, while the C-terminal may have specific properties of tight junctions. The alpha domain might be involved in stabilizing junctions. Plays a role in the regulation of cell migration by targeting the protein kinase MRCKb to the leading edge of migrating cells. Interacts with BVES (via the C-terminus cytoplasmic tail). Interacts with HSPA4 and KIRREL1. Forms homodimers and heterodimers with ZO-2 or ZO-3. Interacts with occludin, CALM, claudins, CGN, CXADR, GJA12, GJD3 and UBN1. Interacts (via ZU5 domain) with MRCKb and MYZAP. Interacts (via PDZ domain) with Cx43. ZO-2 and ZO-3 shuttle between the TJ and the nucleus, where they may regulate gene expression. TJ, or zonula occludens, are the closely associated areas of two cells whose membranes are tightly joined together. They are composed of a branching network of strands, the efficiency of which increases exponentially with the number of strands. The strands associate with transmembrane proteins that bind to similar proteins on adjacent cells, and with submembranous proteins that are anchored to the actin component of the cytoskeleton. Thus, TJs join together the cytoskeletons of adjacent cells. They endow tissues with substantial form, shape and location, enforce cellular polarity, and form barriers to molecules and pathogens. Molecules forming the membranous part of TJs include occludin, claudins, tricellulin and junctional adhesion molecules. These molecules interact with the proteins ZO-1, ZO-2 and ZO-3. Tight junction proteins can be up- or downregulated in cancer and are involved in the epithelial-mesenchymal transitions (EMT) in tumors. Alternative splicing produces two isoforms. The long isoform is found in most epithelial cell junctions. The short isoform is found both in endothelial cells and the highly specialized epithelial junctions of renal glomeruli and Sertoli cells of the seminiferous tubules. Protein type: Motility/polarity/chemotaxis; Adaptor/scaffold. Cellular Component: apical junction complex; intercellular canaliculus; tight junction; cell surface; apicolateral plasma membrane; basolateral plasma membrane; intercellular junction; cell-cell adherens junction; adherens junction; membrane; apical part of cell; apical plasma membrane; cytoplasm; gap junction; plasma membrane; nucleus; cell junction. Molecular Function: calmodulin binding; protein C-terminus binding; protein domain specific binding; protein binding. Biological Process: sensory perception of sound; blastocyst formation

size1 :

48-Strip-Wells

price1 :

435 USD

size2 :

96-Strip-Wells

price2 :

600

more info or order :

MyBioSource product webpage