Human Mitotic spindle assembly checkpoint protein MAD2A, MAD2L1 ELISA Kit | MyBioSource MBS9323845 product information

product summary

company name :

MyBioSource

product type :

ELISA/assay

product name :

Human Mitotic spindle assembly checkpoint protein MAD2A, MAD2L1 ELISA Kit

catalog :

MBS9323845

quantity :

48-Strip-Wells

price :

470 USD

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS9323845

products type :

ELISA Kit

products full name :

Human Mitotic spindle assembly checkpoint protein MAD2A, MAD2L1 ELISA Kit

products short name :

[MAD2 mitotic arrest deficient-like 1 (yeast)]

products name syn :

[Human Mitotic spindle assembly checkpoint protein MAD2A (MAD2L1) ELISA kit; HSMAD2; MAD2; MAD2 (mitotic arrest deficient; yeast; homolog) -like 1; MAD2-like 1; MAD2-like protein 1; mitotic arrest deficient; yeast; homolog-like 1; MAD2 mitotic arrest deficient-like 1 (yeast)]

other names :

[mitotic spindle assembly checkpoint protein MAD2A; Mitotic spindle assembly checkpoint protein MAD2A; mitotic spindle assembly checkpoint protein MAD2A; MAD2-like protein 1; mitotic arrest deficient 2-like protein 1; mitotic arrest deficient, yeast, homolog-like 1; MAD2 (mitotic arrest deficient, yeast, homolog)-like 1; MAD2 mitotic arrest deficient-like 1 (yeast); Mitotic arrest deficient 2-like protein 1; MAD2-like protein 1]

products gene name :

[MAD2L1]

other gene names :

[MAD2L1; MAD2L1; MAD2; HSMAD2; MAD2; HsMAD2; MAD2-like protein 1]

uniprot entry name :

MD2L1_HUMAN

reactivity :

Human

specificity :

No significant cross-reactivity or interference between this analyte and analogues is observed.

storage stability :

Store all reagents at 2-8 degree C

other info1 :

Samples: Undiluted original Human body fluids, tissue homogenates, secretions or feces samples. This kit is NOT suitable for assaying non-biological sources of substances. Assay Type: Sandwich. Detection Range: 0.5 ng/ml - 16 ng/ml. Sensitivity: 0.1 ng/ml.

other info2 :

Intra-assay Precision: Intra-assay CV (%) is less than 15%. Inter-assay Precision: Inter-assay CV (%) is less than 15%. [CV(%) = SD/mean ×100].

products description :

Background/Introduction: This Quantitative Sandwich ELISA kit is only for in vitro research use only, NOT for drug, household, therapeutic or diagnostic applications! This kit is intended to be used for determination the level of MAD2L1 (hereafter termed "analyte") in undiluted original Human body fluids, tissue homogenates, secretions or feces samples. This kit is NOT suitable for assaying non-biological sources of substances.

ncbi gi num :

4505067

ncbi acc num :

NP_002349.1

ncbi gb acc num :

NM_002358.3

uniprot acc num :

Q13257

ncbi mol weight :

23,510 Da

ncbi pathways :

APC/C-mediated Degradation Of Cell Cycle Proteins Pathway (105825); APC/C:Cdc20 Mediated Degradation Of Mitotic Proteins Pathway (105831); Activation Of APC/C And APC/C:Cdc20 Mediated Degradation Of Mitotic Proteins Pathway (105829); Amplification Of Signal From Unattached Kinetochores Via A MAD2 Inhibitory Signal Pathway (105761); Amplification Of Signal From The Kinetochores Pathway (105760); Cell Cycle Pathway (530733); Cell Cycle Checkpoints Pathway (105739); Cell Cycle, Mitotic Pathway (105765); Cell Cycle Pathway (198811); Cell Cycle Pathway (83054)

ncbi summary :

MAD2L1 is a component of the mitotic spindle assembly checkpoint that prevents the onset of anaphase until all chromosomes are properly aligned at the metaphase plate. MAD2L1 is related to the MAD2L2 gene located on chromosome 1. A MAD2 pseudogene has been mapped to chromosome 14. [provided by RefSeq, Jul 2008]

uniprot summary :

MAD2L1: required for the mitotic checkpoint which monitors the process of kinetochore-spindle attachment and delays the onset of anaphase when this process is not complete. Inhibits the activity of the anaphase promoting complex by sequestering CDC20 until all chromosomes are aligned at the metaphase plate. Interacts with Cdc20, MAD2L1BP and with ADAM17/TACE. Protein type: Cell cycle regulation. Chromosomal Location of Human Ortholog: 4q27. Cellular Component: kinetochore; spindle pole; perinuclear region of cytoplasm; nuclear pore; cytosol; nucleus. Molecular Function: identical protein binding; protein binding; protein homodimerization activity. Biological Process: negative regulation of ubiquitin-protein ligase activity during mitotic cell cycle; mitotic sister chromatid segregation; regulation of ubiquitin-protein ligase activity during mitotic cell cycle; anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process; cell division; mitotic cell cycle checkpoint; mitotic cell cycle spindle assembly checkpoint; negative regulation of mitotic cell cycle; mitotic cell cycle; negative regulation of protein catabolic process; negative regulation of apoptosis

size1 :

48-Strip-Wells

price1 :

470 USD

size2 :

96-Strip-Wells

price2 :

680

size3 :

5x96-Strip-Wells

price3 :

3100

size4 :

10x96-Strip-Wells

price4 :

6095

more info or order :

MyBioSource product webpage