Human Fructose-1, 6-bisphosphatase isozyme 2, FBP2 ELISA Kit | MyBioSource MBS9323366 product information

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product summary

company name :

MyBioSource

product type :

ELISA/assay

product name :

Human Fructose-1, 6-bisphosphatase isozyme 2, FBP2 ELISA Kit

catalog :

MBS9323366

quantity :

48-Strip-Wells

price :

470 USD

product information

catalog number :

MBS9323366

products type :

ELISA Kit

products full name :

Human Fructose-1, 6-bisphosphatase isozyme 2, FBP2 ELISA Kit

products short name :

[fructose-1, 6-bisphosphatase 2]

products name syn :

[Human Fructose-1; 6-bisphosphatase isozyme 2 (FBP2) ELISA kit; MGC142192; D-fructose-1; 6-bisphosphate 1-phosphohydrolase; FBPase; fructose-1; 6-bisphosphatase isozyme 2; hexosediphosphatase; muscle fructose-bisphosphatase; fructose-1; 6-bisphosphatase 2]

other names :

[fructose-1,6-bisphosphatase isozyme 2; Fructose-1,6-bisphosphatase isozyme 2; fructose-1,6-bisphosphatase isozyme 2; FBPase 2; muscle FBPase; hexosediphosphatase; muscle fructose-bisphosphatase; D-fructose-1,6-bisphosphate 1-phosphohydrolase 2; fructose-1,6-bisphosphatase 2; D-fructose-1,6-bisphosphate 1-phosphohydrolase 2; Muscle FBPase]

products gene name :

[FBP2]

other gene names :

[FBP2; FBP2; FBPase 2]

uniprot entry name :

F16P2_HUMAN

reactivity :

Human

specificity :

No significant cross-reactivity or interference between this analyte and analogues is observed.

storage stability :

Store all reagents at 2-8 degree C

other info1 :

Samples: Body fluids, tissue homogenates, secretions or feces samples. Assay Type: Quantitative Sandwich. Detection Range: 0.625 ng/ml - 20 ng/ml. Sensitivity: 0.1 ng/ml.

other info2 :

Intra-assay Precision: Intra-assay CV (%) is less than 15%. Inter-assay Precision: Inter-assay CV (%) is less than 15%. [CV(%) = SD/mean ×100].

products description :

Background/Introduction: This Quantitative Sandwich ELISA kit is only for in vitro research use only, not for drug, household, therapeutic or diagnostic applications! This kit is intended to be used for determination the level of FBP2 (hereafter termed "analyte") in undiluted original Human body fluids, tissue homogenates, secretions or feces samples. This kit is NOT suitable for assaying non-biological sources of substances.

ncbi gi num :

22907028

ncbi acc num :

NP_003828.2

ncbi gb acc num :

NM_003837.3

uniprot acc num :

O00757

ncbi mol weight :

36,743 Da

ncbi pathways :

Fructose And Mannose Metabolism Pathway (82930); Fructose And Mannose Metabolism Pathway (291); Gluconeogenesis Pathway (106204); Gluconeogenesis, Oxaloacetate = Fructose-6P Pathway (413342); Gluconeogenesis, Oxaloacetate = Fructose-6P Pathway (468196); Glucose Metabolism Pathway (106199); Glycolysis / Gluconeogenesis Pathway (82926); Glycolysis / Gluconeogenesis Pathway (287); Glycolysis And Gluconeogenesis Pathway (198814); Insulin Signaling Pathway (83090)

ncbi summary :

This gene encodes a gluconeogenesis regulatory enzyme which catalyzes the hydrolysis of fructose 1,6-bisphosphate to fructose 6-phosphate and inorganic phosphate. [provided by RefSeq, Jul 2008]

uniprot summary :

FBPase 2: a key enzyme of gluconeogenesis that catalyzes the hydrolysis of fructose 1,6-bisphosphate to fructose 6-phosphate, a precursor to glucose 6-phosphate. A regulator of glucose synthesis from non-carbohydrates. Two paralogs of this enzyme exists in humans: FBP1 is expressed in the liver and gluconeogenic tissues, and FBP2 in striated muscle. FBP2 is only isozyme expressed in striated muscle and it is widely expressed in cells that are nongluconeogenic. Both forms are inhibited allosterically by AMP, NAD and Ca2+. The muscle form is about 100-fold more sensitive to AMP and NAD, and about 1000-fold more sensitive to inhibition by Ca2+, the major activator of glycolysis in striated muscle. Forms an active complex with aldolase that binds to the sarcomeric Z-line, which is disrupted by elevated calcium levels, blocking glycogen synthesis during exercise. Forms homotetramers that are stabilized in the active state by divalent cations (Mg2+, Mn2+ , Co+2, or Zn2+). Its interaction with aldolase appears to desensitizes it to inhibition by AMP and, partially, by Ca2+. Up to 50% of lactate generated in striated muscle is converted to glycogen. Protein type: EC 3.1.3.11; Carbohydrate Metabolism - pentose phosphate pathway; Phosphatase (non-protein); Carbohydrate Metabolism - glycolysis and gluconeogenesis; Carbohydrate Metabolism - fructose and mannose. Chromosomal Location of Human Ortholog: 9q22.3. Cellular Component: cell junction; Z disc; nucleus; cytosol. Molecular Function: metal ion binding; fructose-bisphosphatase activity. Biological Process: dephosphorylation; carbohydrate metabolic process; glucose metabolic process; pathogenesis; fructose metabolic process; gluconeogenesis

size1 :

48-Strip-Wells

price1 :

470 USD

size2 :

96-Strip-Wells

price2 :

680

size3 :

5x96-Strip-Wells

price3 :

3100

size4 :

10x96-Strip-Wells

price4 :

6095