Human Proprotein convertase subtilisin/kexin type 6, PCSK6 ELISA Kit | MyBioSource MBS9323189 product information

product summary

company name :

MyBioSource

product type :

ELISA/assay

product name :

Human Proprotein convertase subtilisin/kexin type 6, PCSK6 ELISA Kit

catalog :

MBS9323189

quantity :

48-Strip-Wells

price :

470 USD

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS9323189

products type :

ELISA Kit

products full name :

Human Proprotein convertase subtilisin/kexin type 6, PCSK6 ELISA Kit

products short name :

[proprotein convertase subtilisin/kexin type 6]

products name syn :

[Human Proprotein convertase subtilisin/kexin type 6 (PCSK6) ELISA kit; PACE4; SPC4; paired basic amino acid cleaving system 4; subtilisin-like proprotein convertase 4; subtilisin-like protease; subtilisin/kexin-like protease PACE4; proprotein convertase subtilisin/kexin type 6]

other names :

[proprotein convertase subtilisin/kexin type 6 isoform i preproprotein; Proprotein convertase subtilisin/kexin type 6; proprotein convertase subtilisin/kexin type 6; subtilisin/kexin-like protease PACE4; subtilisin-like proprotein convertase 4; paired basic amino acid cleaving enzyme 4; paired basic amino acid cleaving system 4; proprotein convertase subtilisin/kexin type 6; Paired basic amino acid cleaving enzyme 4; Subtilisin-like proprotein convertase 4; SPC4; Subtilisin/kexin-like protease PACE4]

products gene name :

[PCSK6]

other gene names :

[PCSK6; PCSK6; SPC4; PACE4; PACE4; SPC4]

uniprot entry name :

PCSK6_HUMAN

reactivity :

Human

specificity :

No significant cross-reactivity or interference between this analyte and analogues is observed.

storage stability :

Store all reagents at 2-8 degree C

other info1 :

Samples: Human Body Fluids And Tissue Homogenates. Assay Type: Quantitative Sandwich. Detection Range: 0.625ng/ml-20ng/ml. Sensitivity: 0.1ng/ml.

other info2 :

Intra-assay Precision: Intra-assay CV (%) are less than 15%. Inter-assay Precision: Inter-assay CV (?) are less than 15%. [CV(%) = SD/mean ×100]. All CV% should be compared by concentration, not compared by OD values.

products description :

Background/Introduction: This Quantitative Sandwich ELISA kit is for lab reagent/research use only, not for drug, household, therapeutic or diagnostic applications! This kit is intended to be used for determine the level of PCSK1 (hereafter termed "analyte") in undiluted original Human body fluids and tissue homogenates. This kit is NOT suitable for assaying non-biological sources of substances.

ncbi gi num :

604723363

ncbi acc num :

NP_001278238.1

ncbi gb acc num :

NM_001291309.1

uniprot acc num :

P29122

ncbi mol weight :

106,420 Da

ncbi pathways :

Developmental Biology Pathway (477129); NGF Processing Pathway (106440); Signal Transduction Pathway (477114); Signaling By NODAL Pathway (477130); Signalling By NGF Pathway (106439)

ncbi summary :

This gene encodes a member of the subtilisin-like proprotein convertase family, which includes proteases that process protein and peptide precursors trafficking through regulated or constitutive branches of the secretory pathway. The encoded protein undergoes an initial autocatalytic processing event in the ER to generate a heterodimer which exits the ER and sorts to the trans-Golgi network where a second autocatalytic event takes place and the catalytic activity is acquired. The encoded protease is constitutively secreted into the extracellular matrix and expressed in many tissues, including neuroendocrine, liver, gut, and brain. This gene encodes one of the seven basic amino acid-specific members which cleave their substrates at single or paired basic residues. Some of its substrates include transforming growth factor beta related proteins, proalbumin, and von Willebrand factor. This gene is thought to play a role in tumor progression and left-right patterning. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Feb 2014]

uniprot summary :

PCSK6: Likely to represent an endoprotease activity within the constitutive secretory pathway, with unique restricted distribution in both neuroendocrine and non-neuroendocrine tissues and capable of cleavage at the RX(K/R)R consensus motif. Belongs to the peptidase S8 family. 8 isoforms of the human protein are produced by alternative splicing. Protein type: Secreted; Protease; Secreted, signal peptide; EC 3.4.21.-. Chromosomal Location of Human Ortholog: 15q26.3. Cellular Component: extracellular matrix; extracellular space; cell surface; membrane; Golgi lumen; endoplasmic reticulum. Molecular Function: heparin binding; serine-type endopeptidase activity; endopeptidase activity; nerve growth factor binding. Biological Process: nerve growth factor processing; zygotic determination of anterior/posterior axis, embryo; nerve growth factor receptor signaling pathway; glycoprotein metabolic process; regulation of BMP signaling pathway; peptide hormone processing; protein processing; proteolysis; determination of left/right symmetry; nerve growth factor production; secretion by cell

size1 :

48-Strip-Wells

price1 :

470 USD

size2 :

96-Strip-Wells

price2 :

680

size3 :

5x96-Strip-Wells

price3 :

3100

size4 :

10x96-Strip-Wells

price4 :

6095

more info or order :

MyBioSource product webpage