Human Vacuolar protein sorting-associated protein 4A, VPS4A ELISA Kit | MyBioSource MBS9322824 product information

product summary

company name :

MyBioSource

product type :

ELISA/assay

product name :

Human Vacuolar protein sorting-associated protein 4A, VPS4A ELISA Kit

catalog :

MBS9322824

quantity :

48-Strip-Wells

price :

435 USD

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS9322824

products type :

ELISA Kit

products full name :

Human Vacuolar protein sorting-associated protein 4A, VPS4A ELISA Kit

products short name :

vacuolar protein sorting 4 homolog A (S. cerevisiae)

products name syn :

Human Vacuolar protein sorting-associated protein 4A (VPS4A) ELISA kit; FLJ22197; SKD1; SKD1A; SKD2; VPS4; VPS4-1; SKD1-homolog; vacuolar protein sorting factor 4A; vacuolar sorting protein 4; vacuolar protein sorting 4 homolog A (S. cerevisiae)

other names :

vacuolar protein sorting-associated protein 4A; Vacuolar protein sorting-associated protein 4A; vacuolar protein sorting-associated protein 4A; hVPS4; SKD1-homolog; vacuolar sorting protein 4; vacuolar protein sorting factor 4A; vacuolar protein sorting 4 homolog A (S. cerevisiae); Protein SKD2; VPS4-1; hVPS4

products gene name :

VPS4A

other gene names :

VPS4A; VPS4A; SKD1; SKD2; VPS4; SKD1A; VPS4-1; VPS4; hVPS4

uniprot entry name :

VPS4A_HUMAN

reactivity :

Human

storage stability :

Store all reagents at 2-8 degree C

other info1 :

Samples: Serum, Plasma and Tissue Homogenate. Assay Type: Sandwich. Detection Range: 0.25 ng/ml - 8 ng/ml. Sensitivity: 0.1 ng/ml.

other info2 :

Intended Uses: This Quantitative Sandwich ELISA kit is only for in vitro research use only, not for drug, household, therapeutic or diagnostic applications! This kit is intended to be used for determination the level of VPS4A (hereafter termed this analyte) in Human serum, plasma and tissue homogenate samples.

products description :

Background: This Quantitative Sandwich ELISA kit is only for in vitro research use only, not for drug, household, therapeutic or diagnostic applications! This kit is intended to be used for determination the level of VPS4A (hereafter termed this analyte) in Human serum, plasma and tissue homogenate samples.

ncbi gi num :

7019569

ncbi acc num :

NP_037377.1

ncbi gb acc num :

NM_013245.2

uniprot acc num :

Q9UN37

ncbi mol weight :

48,898 Da

ncbi pathways :

CXCR4-mediated Signaling Events Pathway (137910); Endocytosis Pathway (102279); Endocytosis Pathway (102181); Endosomal Sorting Complex Required For Transport (ESCRT) Pathway (205244); Membrane Trafficking Pathway (106160)

ncbi summary :

The protein encoded by this gene is a member of the AAA protein family (ATPases associated with diverse cellular activities), and is the homolog of the yeast Vps4 protein. In humans, two paralogs of the yeast protein have been identified. The former share a high degree of aa sequence similarity with each other, and also with yeast Vps4 and mouse Skd1 proteins. The mouse Skd1 (suppressor of K+ transport defect 1) has been shown to be really an yeast Vps4 ortholog. Functional studies indicate that both human paralogs associate with the endosomal compartments, and are involved in intracellular protein trafficking, similar to Vps4 protein in yeast. The gene encoding this paralog has been mapped to chromosome 16; the gene for the other resides on chromosome 18. [provided by RefSeq, Jul 2008]

uniprot summary :

VPS4A: Involved in late steps of the endosomal multivesicular bodies (MVB) pathway. Recognizes membrane-associated ESCRT-III assemblies and catalyzes their disassembly, possibly in combination with membrane fission. Redistributes the ESCRT-III components to the cytoplasm for further rounds of MVB sorting. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. In conjunction with the ESCRT machinery also appears to function in topologically equivalent membrane fission events, such as the terminal stages of cytokinesis and enveloped virus budding (HIV-1 and other lentiviruses). Involved in cytokinesis. Belongs to the AAA ATPase family. Protein type: EC 3.6.4.6; Vesicle. Chromosomal Location of Human Ortholog: 16q22.1. Cellular Component: spindle pole; centrosome; late endosome membrane; perinuclear region of cytoplasm; cytoplasm; midbody; nucleus; cytosol. Molecular Function: protein C-terminus binding; protein domain specific binding; protein binding; ATPase activity, coupled; microtubule-severing ATPase activity; ATP binding. Biological Process: vesicle-mediated transport; protein transport; viral reproduction; cell separation during cytokinesis; ubiquitin-dependent protein catabolic process via the multivesicular body pathway; abscission; cytokinesis; viral infectious cycle; endosome transport; mitotic metaphase plate congression; cytoplasmic microtubule organization and biogenesis; negative regulation of cytokinesis; nuclear organization and biogenesis; vacuole organization and biogenesis

size1 :

48-Strip-Wells

price1 :

435 USD

size2 :

96-Strip-Wells

price2 :

600

more info or order :

MyBioSource product webpage