Human Transient receptor potential Cation channel subfamily M member 7, TRPM7 ELISA Kit | MyBioSource MBS9322665 product information

product summary

company name :

MyBioSource

product type :

ELISA/assay

product name :

Human Transient receptor potential Cation channel subfamily M member 7, TRPM7 ELISA Kit

catalog :

MBS9322665

quantity :

48-Strip-Wells

price :

470 USD

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS9322665

products type :

ELISA Kit

products full name :

Human Transient receptor potential Cation channel subfamily M member 7, TRPM7 ELISA Kit

products short name :

[transient receptor potential cation channel, subfamily M, member 7]

products name syn :

[Human Transient receptor potential cation channel subfamily M member 7 (TRPM7) ELISA kit; CHAK; CHAK1; FLJ20117; FLJ25718; LTRPC7; TRP-PLIK; LTRPC ion channel family member 7; transient receptor potential cation channel; subfamily M; member 7]

other names :

[transient receptor potential cation channel subfamily M member 7 isoform a; Transient receptor potential cation channel subfamily M member 7; transient receptor potential cation channel subfamily M member 7; channel-kinase 1; LTRPC ion channel family member 7; long transient receptor potential channel 7; transient receptor potential-phospholipase C-interacting kinase; transient receptor potential cation channel, subfamily M, member 7; Channel-kinase 1; Long transient receptor potential channel 7; LTrpC-7; LTrpC7]

products gene name :

[TRPM7]

other gene names :

[TRPM7; TRPM7; CHAK; CHAK1; ALSPDC; LTRPC7; LTrpC-7; TRP-PLIK; CHAK1; LTRPC7; LTrpC-7; LTrpC7]

uniprot entry name :

TRPM7_HUMAN

reactivity :

Human

specificity :

No significant cross-reactivity or interference between this analyte and analogues is observed.

storage stability :

Store all reagents at 2-8 degree C

other info1 :

Samples: Body fluids, tissue homogenates, secretions or feces samples. Assay Type: Quantitative Sandwich. Detection Range: 0.25 ng/ml - 8 ng/ml. Sensitivity: 0.1 ng/ml.

other info2 :

Intra-assay Precision: Intra-assay CV (%) is less than 15%. Inter-assay Precision: Inter-assay CV (%) is less than 15%. [CV(%) = SD/mean ×100].

products description :

Background/Introduction: This Quantitative Sandwich ELISA kit is only for in vitro research use only, not for drug, household, therapeutic or diagnostic applications! This kit is intended to be used for determination the level of TRPM7 (hereafter termed "analyte") in undiluted original Human body fluids, tissue homogenates, secretions or feces samples. This kit is NOT suitable for assaying non-biological sources of substances.

ncbi gi num :

148612863

ncbi acc num :

NP_060142.3

ncbi gb acc num :

NM_017672.5

uniprot acc num :

Q96QT4

ncbi mol weight :

212,697 Da

ncbi pathways :

Mineral Absorption Pathway (212237); Mineral Absorption Pathway (212220)

ncbi summary :

The protein encoded by this gene is both an ion channel and a serine/threonine protein kinase. The kinase activity is essential for the ion channel function, which serves to increase intracellular calcium levels and to help regulate magnesium ion homeostasis. Defects in this gene are a cause of amyotrophic lateral sclerosis-parkinsonism/dementia complex of Guam. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Jul 2014]

uniprot summary :

ChaK1: is an unusual and ubiquitous bifunctional protein containing a transient receptor potential (TRP) ion channel fused to a protein kinase of the Atypical alpha group. Required for early embryonic development and for maintaining cardiac automaticity. The channel conducts Zn(2+), Mg(2+), and Ca(2+) as well as monovalent cations. The kinase can be cleaved from the channel domain. The cleaved kinase translocates to the nucleus where it binds chromatin-remodeling complexes including Polycomb, and phosphorylates specific histone residues. The kinase activity is essential for the channel function, and channel function is critical to maintain physiological intracellular magnesium levels. Plays a key role in oxidative stress-induced cell death. TRP voltage-independent calcium-permeable cation channels are divided into six subfamilies, two of which (TRPC and TRPM) have members that are widely expressed and activated by oxidative stress. Is activated by reactive oxygen/nitrogen species, resulting in cation conductance and anoxic neuronal cell death. This phenotype is rescued by suppression of ChaK1 expression. Related to ChaK2, another Atypical alpha kinase fused to a TRP ion channel protein. Protein type: Protein kinase, atypical; Membrane protein, integral; EC 2.7.11.1; Membrane protein, multi-pass; Kinase, protein; Channel, cation; ATYPICAL group; Alpha family; ChaK subfamily. Chromosomal Location of Human Ortholog: 15q21. Cellular Component: ruffle; plasma membrane; integral to membrane. Molecular Function: protein serine/threonine kinase activity; myosin binding; calcium channel activity; metal ion binding; actin binding; ATP binding. Biological Process: protein amino acid autophosphorylation; actomyosin structure organization and biogenesis; calcium-dependent cell-matrix adhesion; transmembrane transport. Disease: Amyotrophic Lateral Sclerosis-parkinsonism/dementia Complex 1

size1 :

48-Strip-Wells

price1 :

470 USD

size2 :

96-Strip-Wells

price2 :

680

size3 :

5x96-Strip-Wells

price3 :

3100

size4 :

10x96-Strip-Wells

price4 :

6095

more info or order :

MyBioSource product webpage