Rat DNA mismatch repair protein Msh2, MSH2 ELISA Kit | MyBioSource MBS9321793 product information

product summary

company name :

MyBioSource

product type :

ELISA/assay

product name :

Rat DNA mismatch repair protein Msh2, MSH2 ELISA Kit

catalog :

MBS9321793

quantity :

48-Strip-Wells

price :

435 USD

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS9321793

products type :

ELISA Kit

products full name :

Rat DNA mismatch repair protein Msh2, MSH2 ELISA Kit

products short name :

mutS homolog 2, colon cancer, nonpolyposis type 1 (E. coli)

products name syn :

Rat DNA mismatch repair protein Msh2 (MSH2) ELISA kit; COCA1; FCC1; HNPCC; HNPCC1; LCFS2; mutS homolog 2; mutS homolog 2; colon cancer; nonpolyposis type 1 (E. coli)

other names :

DNA mismatch repair protein Msh2; DNA mismatch repair protein Msh2; DNA mismatch repair protein Msh2; mutS protein homolog 2; mutS homolog 2; MutS protein homolog 2

products gene name :

MSH2

other gene names :

Msh2; Msh2

uniprot entry name :

MSH2_RAT

reactivity :

Rat

storage stability :

Store all reagents at 2-8 degree C

ncbi gi num :

13591999

ncbi acc num :

NP_112320.1

ncbi gb acc num :

NM_031058.1

uniprot acc num :

P54275

ncbi mol weight :

104,028 Da

ncbi pathways :

BRCA1-associated Genome Surveillance Complex (BASC) Pathway (434754); BRCA1-associated Genome Surveillance Complex (BASC) Pathway (890555); Colorectal Cancer Pathway (83494); Colorectal Cancer Pathway (518); Mismatch Repair Pathway (198491); Mismatch Repair Pathway (83437); Mismatch Repair Pathway (453); Pathways In Cancer (83493)

ncbi summary :

mismatch repair protein; may have an important role in spermatogenesis [RGD, Feb 2006]

uniprot summary :

MSH2: Component of the post-replicative DNA mismatch repair system (MMR). Forms two different heterodimers: MutS alpha (MSH2- MSH6 heterodimer) and MutS beta (MSH2-MSH3 heterodimer) which binds to DNA mismatches thereby initiating DNA repair. When bound, heterodimers bend the DNA helix and shields approximately 20 base pairs. MutS alpha recognizes single base mismatches and dinucleotide insertion-deletion loops (IDL) in the DNA. MutS beta recognizes larger insertion-deletion loops up to 13 nucleotides long. After mismatch binding, MutS alpha or beta forms a ternary complex with the MutL alpha heterodimer, which is thought to be responsible for directing the downstream MMR events, including strand discrimination, excision, and resynthesis. ATP binding and hydrolysis play a pivotal role in mismatch repair functions. The ATPase activity associated with MutS alpha regulates binding similar to a molecular switch: mismatched DNA provokes ADP-- ATP exchange, resulting in a discernible conformational transition that converts MutS alpha into a sliding clamp capable of hydrolysis-independent diffusion along the DNA backbone. This transition is crucial for mismatch repair. MutS alpha may also play a role in DNA homologous recombination repair. In melanocytes may modulate both UV-B-induced cell cycle regulation and apoptosis. Heterodimer consisting of MSH2-MSH6 (MutS alpha) or MSH2- MSH3 (MutS beta). Both heterodimer form a ternary complex with MutL alpha (MLH1-PMS1). Interacts with EXO1. Part of the BRCA1- associated genome surveillance complex (BASC), which contains BRCA1, MSH2, MSH6, MLH1, ATM, BLM, PMS2 and the RAD50-MRE11-NBS1 protein complex. This association could be a dynamic process changing throughout the cell cycle and within subnuclear domains. Interacts with ATR. Interacts with SLX4/BTBD12; this interaction is direct and links MutS beta to SLX4, a subunit of different structure-specific endonucleases. Interacts with SMARCAD1. Ubiquitously expressed. Belongs to the DNA mismatch repair MutS family. Protein type: Tumor suppressor; DNA-binding. Cellular Component: nuclear chromosome; membrane; MutSalpha complex; intracellular; nucleus; MutSbeta complex. Molecular Function: protein homodimerization activity; dinucleotide repeat insertion binding; single thymine insertion binding; ATPase activity; magnesium ion binding; loop DNA binding; Y-form DNA binding; enzyme binding; four-way junction DNA binding; single guanine insertion binding; guanine/thymine mispair binding; double-stranded DNA binding; ATP binding; single-stranded DNA binding; protein C-terminus binding; DNA-dependent ATPase activity; double-strand/single-strand DNA junction binding; single base insertion or deletion binding; oxidized purine DNA binding; ADP binding; protein kinase binding; mismatched DNA binding; centromeric DNA binding; DNA binding; damaged DNA binding; MutLalpha complex binding; dinucleotide insertion or deletion binding. Biological Process: somatic recombination of immunoglobulin genes during immune response; determination of adult life span; response to organic cyclic substance; maintenance of DNA repeat elements; germ cell development; positive regulation of helicase activity; double-strand break repair; negative regulation of neuron apoptosis; cell cycle arrest; DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis; oxidative phosphorylation; response to X-ray; response to drug; negative regulation of DNA recombination; mismatch repair; in utero embryonic development; postreplication repair; male gonad development; somatic hypermutation of immunoglobulin genes; isotype switching; response to amino acid stimulus; DNA repair; meiotic mismatch repair; response to UV-B; B cell mediated immunity; DNA damage response, signal transduction resulting in induction of apoptosis; intra-S DNA damage checkpoint; B cell differentiation; somatic recombination of immunoglobulin gene segments; meiotic gene conversion; spermatogenesis; response to DNA damage stimulus; negative regulation of meiotic recombination

size1 :

48-Strip-Wells

price1 :

435 USD

size2 :

96-Strip-Wells

price2 :

600

more info or order :

MyBioSource product webpage