catalog number :
MBS9321709
products type :
ELISA Kit
products full name :
Mouse Retinaldehyde-binding protein 1, RLBP1 ELISA Kit
products short name :
retinaldehyde binding protein 1
products name syn :
Mouse Retinaldehyde-binding protein 1 (RLBP1) ELISA kit; CRALBP; MGC3663; cellular retinaldehyde-binding protein-1; retinaldehyde-binding protein 1; retinaldehyde binding protein 1
other names :
retinaldehyde-binding protein 1; Retinaldehyde-binding protein 1; retinaldehyde-binding protein 1; cellular retinaldehyde-binding protein; retinaldehyde binding protein 1; Cellular retinaldehyde-binding protein
products gene name :
RLBP1
other gene names :
Rlbp1; Rlbp1; CRALBP; 3110056M11Rik; Cralbp
uniprot entry name :
RLBP1_MOUSE
storage stability :
Store all reagents at 2-8 degree C
ncbi acc num :
NP_001166954.1
ncbi gb acc num :
NM_001173483.1
ncbi mol weight :
36,408 Da
ncbi pathways :
Retinol Metabolism Pathway (198314)
uniprot summary :
RLBP1: Soluble retinoid carrier essential the proper function of both rod and cone photoreceptors. Participates in the regeneration of active 11-cis-retinol and 11-cis-retinaldehyde, from the inactive 11-trans products of the rhodopsin photocycle and in the de novo synthesis of these retinoids from 11-trans metabolic precursors. The cycling of retinoids between photoreceptor and adjacent pigment epithelium cells is known as the visual cycle . Defects in RLBP1 are a cause of retinitis pigmentosa autosomal recessive (ARRP). RP leads to degeneration of retinal photoreceptor cells. Patients typically have night vision blindness and loss of midperipheral visual field. As their condition progresses, they lose their far peripheral visual field and eventually central vision as well. Defects in RLBP1 are the cause of Bothnia retinal dystrophy (BRD); also known as Vasterbotten dystrophy. Affected individuals show night blindness from early childhood with features consistent with retinitis punctata albescens and macular degeneration. Defects in RLBP1 are the cause of rod-cone dystrophy Newfoundland (NFRCD). NFRCD is a retinal dystrophy reminiscent of retinitis punctata albescens but with a substantially lower age at onset and more-rapid and distinctive progression. Rod-cone dystrophies results from initial loss of rod photoreceptors, later followed by cone photoreceptors loss. Defects in RLBP1 are a cause of retinitis punctata albescens (RPA). A rare form of stationary night blindness characterized by a delay in the regeneration of cone and rod photopigments. Cellular Component: cytoplasm; intracellular. Molecular Function: transporter activity; 11-cis retinal binding; retinol binding. Biological Process: visual perception; transport; response to stimulus