ELISA/assay

Human tyrosyl-tRNA synthetase, YARS ELISA Kit

MBS9321101

48-Strip-Wells

435 USD

ELISA Kit

Human tyrosyl-tRNA synthetase, YARS ELISA Kit

tyrosyl-tRNA synthetase

Human tyrosyl-tRNA synthetase (YARS) ELISA kit; CMTDIC; TYRRS; YRS; YTS; tyrosine tRNA ligase 1; cytoplasmic; tyrosyl-tRNA synthetase

tyrosine--tRNA ligase, cytoplasmic; Tyrosine--tRNA ligase, cytoplasmic; tyrosine--tRNA ligase, cytoplasmic; tyrosyl--tRNA ligase; tyrosine tRNA ligase 1, cytoplasmic; tyrosyl-tRNA synthetase, cytoplasmic; tyrosyl-tRNA synthetase; Tyrosyl-tRNA synthetase; TyrRS

YARS

YARS; YARS; YRS; YTS; TYRRS; CMTDIC; TyrRS

SYYC_HUMAN

Human

No significant cross-reactivity or interference between this analyte and analogues is observed.

Store all reagents at 2-8 degree C

Assay Type: Sandwich. Detection Range: 0.25 ng/ml - 8 ng/ml. Sensitivity: 0.1 ng/ml.

Intra-assay Precision: Intra-assay CV (%) is less than 15%. Inter-assay Precision: Inter-assay CV (%) is less than 15%. [CV(%) = SD/mean ×100].

Background/Introduction: This Quantitative Sandwich ELISA kit is only for in vitro research use only, not for drug, household, therapeutic or diagnostic applications! This kit is intended to be used for determination the level of YARS (hereafter termed "analyte") in undiluted original Human body fluids, tissue homogenates, secretions or feces samples. This kit is NOT suitable for assaying non-biological sources of substances.

4507947

NP_003671.1

NM_003680.3

P54577

59,143 Da

Aminoacyl-tRNA Biosynthesis Pathway (83030); Aminoacyl-tRNA Biosynthesis Pathway (424); Aminoacyl-tRNA Biosynthesis, Eukaryotes Pathway (413439); Aminoacyl-tRNA Biosynthesis, Eukaryotes Pathway (468360); Cytosolic TRNA Aminoacylation Pathway (105981); Gene Expression Pathway (105937); TRNA Aminoacylation Pathway (105980)

Aminoacyl-tRNA synthetases catalyze the aminoacylation of tRNA by their cognate amino acid. Because of their central role in linking amino acids with nucleotide triplets contained in tRNAs, aminoacyl-tRNA synthetases are thought to be among the first proteins that appeared in evolution. Tyrosyl-tRNA synthetase belongs to the class I tRNA synthetase family. Cytokine activities have also been observed for the human tyrosyl-tRNA synthetase, after it is split into two parts, an N-terminal fragment that harbors the catalytic site and a C-terminal fragment found only in the mammalian enzyme. The N-terminal fragment is an interleukin-8-like cytokine, whereas the released C-terminal fragment is an EMAP II-like cytokine. [provided by RefSeq, Jul 2008]

YARS: Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction: tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr). Defects in YARS are the cause of Charcot-Marie-Tooth disease dominant intermediate type C (CMTDIC). CMTDIC is a form of Charcot-Marie-Tooth disease characterized by clinical and pathologic features intermediate between demyelinating and axonal peripheral neuropathies, and motor median nerve conduction velocities ranging from 25 to 45 m/sec. Belongs to the class-I aminoacyl-tRNA synthetase family. Protein type: EC 6.1.1.1; Ligase. Chromosomal Location of Human Ortholog: 1p35.1. Cellular Component: extracellular space; cytoplasm; cytosol; nucleus. Molecular Function: signal transducer activity; tyrosine-tRNA ligase activity; ATP binding; isoleucine-tRNA ligase activity; interleukin-8 receptor binding; tRNA binding. Biological Process: tyrosyl-tRNA aminoacylation; isoleucyl-tRNA aminoacylation; tRNA aminoacylation for protein translation; apoptosis; gene expression; signal transduction. Disease: Charcot-marie-tooth Disease, Dominant Intermediate C

48-Strip-Wells

435 USD

96-Strip-Wells

600