catalog number :
MBS9321016
products type :
ELISA Kit
products full name :
Human Ran GTPase-activating protein 1, RANGAP1 ELISA Kit
products short name :
[Ran GTPase activating protein 1]
products name syn :
[Human Ran GTPase-activating protein 1 (RANGAP1) ELISA kit; Fug1; KIAA1835; MGC20266; SD; OTTHUMP00000198756; OTTHUMP00000198757; segregation distorter homolog; segregation distortion; Ran GTPase activating protein 1]
other names :
[ran GTPase-activating protein 1; Ran GTPase-activating protein 1; ran GTPase-activating protein 1; segregation distortion; segregation distorter homolog; Ran GTPase activating protein 1]
products gene name :
[RANGAP1]
other gene names :
[RANGAP1; RANGAP1; SD; Fug1; RANGAP; KIAA1835; SD; RanGAP1]
uniprot entry name :
RAGP1_HUMAN
specificity :
No significant cross-reactivity or interference between this analyte and analogues is observed.
storage stability :
Store all reagents at 2-8 degree C
other info1 :
Samples: Human Body Fluids And Tissue Homogenates. Assay Type: Quantitative Sandwich. Detection Range: 6.25ng/ml-200ng/ml. Sensitivity: 1.0ng/ml.
other info2 :
Intra-assay Precision: Intra-assay CV (%) is less than 15%. Inter-assay Precision: Inter-assay CV (%) is less than 15%. [CV(%) = SD/mean ×100]. All CV% should be compared by concentration, not compared by OD values.
products description :
Background/Introduction: This Quantitative Sandwich ELISA kit is for lab reagent/research use only, not for drug, household, therapeutic or diagnostic applications! This kit is intended to be used for determine the level of RAN (hereafter termed "analyte") in undiluted original Human body fluids and tissue homogenates. This kit is NOT suitable for assaying non-biological sources of substances.
ncbi acc num :
NP_001265580.1
ncbi gb acc num :
NM_001278651.1
ncbi mol weight :
63,542 Da
ncbi pathways :
Cell Cycle Pathway (530733); Cell Cycle, Mitotic Pathway (105765); DNA Replication Pathway (105897); Disease Pathway (530764); HIV Infection Pathway (105983); HIV Life Cycle Pathway (105984); Host Interactions Of HIV Factors Pathway (106010); Interactions Of Rev With Host Cellular Proteins Pathway (106014); Late Phase Of HIV Life Cycle Pathway (105995); M Phase Pathway (105812)
ncbi summary :
This gene encodes a protein that associates with the nuclear pore complex and participates in the regulation of nuclear transport. The encoded protein interacts with Ras-related nuclear protein 1 (RAN) and regulates guanosine triphosphate (GTP)-binding and exchange. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]
uniprot summary :
RANGAP1: a cytoplasmic GTPase activator for the Ras-related regulatory protein Ran, converting it to the putatively inactive GDP-bound state. Antagonist of RCC1, a regulator molecule that keeps RAN in the active, GTP-bound state. RanGAP1 and RCC1 control RAN-dependent transport between the nucleus and cytoplasm. RanGAP1 is a key regulator of the RAN GTP/GDP cycle. Homodimerizes. Forms a tight complex in association with RANBP2 and the ubiquitin-conjugating enzyme E2 (UBC9). Protein type: GAPs, Ras; GAPs. Chromosomal Location of Human Ortholog: 22q13. Cellular Component: kinetochore; spindle pole; nuclear membrane; perinuclear region of cytoplasm; cytoplasm; nuclear pore; cytosol. Molecular Function: protein binding. Biological Process: negative regulation of protein export from nucleus; mitotic cell cycle; signal transduction
size4 :
10x96-Strip-Wells