Human Achaete-scute homolog 1, ASCL1 ELISA Kit | MyBioSource MBS9321011 product information

product summary

company name :

MyBioSource

product type :

ELISA/assay

product name :

Human Achaete-scute homolog 1, ASCL1 ELISA Kit

catalog :

MBS9321011

quantity :

48-Strip-Wells

price :

435 USD

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS9321011

products type :

ELISA Kit

products full name :

Human Achaete-scute homolog 1, ASCL1 ELISA Kit

products short name :

achaete-scute complex homolog 1 (Drosophila)

products name syn :

Human Achaete-scute homolog 1 (ASCL1) ELISA kit; ASH1; HASH1; MASH1; bHLHa46; achaete scute protein; achaete-scute complex homolog 1; achaete-scute complex-like 1; achaete-scute complex homolog 1 (Drosophila)

other names :

achaete-scute homolog 1; Achaete-scute homolog 1; achaete-scute homolog 1; ASH-1; achaete scute protein; achaete-scute complex-like 1; achaete-scute complex homolog 1; class A basic helix-loop-helix protein 46; achaete-scute family bHLH transcription factor 1; Class A basic helix-loop-helix protein 46; bHLHa46

products gene name :

ASCL1

other gene names :

ASCL1; ASCL1; ASH1; HASH1; MASH1; bHLHa46; ASH1; BHLHA46; HASH1; ASH-1; hASH1; bHLHa46

uniprot entry name :

ASCL1_HUMAN

reactivity :

Human

specificity :

No significant cross-reactivity or interference between this analyte and analogues is observed.

storage stability :

Store all reagents at 2-8 degree C

other info1 :

Assay Type: Sandwich. Detection Range: 3.12 ng/ml - 100 ng/ml. Sensitivity: The sensitivity of this kit is 1.0 ng/ml.

other info2 :

Intra-assay Precision: Intra-assay CV (%) is less than 15%. Inter-assay Precision: Inter-assay CV (%) is less than 15%. [CV(%) = SD/mean ×100].

products description :

Background/Introduction: This Quantitative Sandwich ELISA kit is only for in vitro research use only, not for drug, household, therapeutic or diagnostic applications! This kit is intended to be used for determination the level of ASCL1 (hereafter termed this analyte) in undiluted original Human body fluids, tissue homogenates, secretions and feces samples.

ncbi gi num :

55743094

ncbi acc num :

NP_004307.2

ncbi gb acc num :

NM_004316.3

uniprot acc num :

P50553

ncbi mol weight :

25,454 Da

ncbi pathways :

Delta-Notch Signaling Pathway (198879); Notch-mediated HES/HEY Network Pathway (169347); SIDS Susceptibility Pathways (198901)

ncbi summary :

This gene encodes a member of the basic helix-loop-helix (BHLH) family of transcription factors. The protein activates transcription by binding to the E box (5'-CANNTG-3'). Dimerization with other BHLH proteins is required for efficient DNA binding. This protein plays a role in the neuronal commitment and differentiation and in the generation of olfactory and autonomic neurons. Mutations in this gene may contribute to the congenital central hypoventilation syndrome (CCHS) phenotype in rare cases. [provided by RefSeq, Jul 2008]

uniprot summary :

ASCL1: Transcriptional regulator. May play a role at early stages of development of specific neural lineages in most regions of the CNS, and of several lineages in the PNS. Essential for the generation of olfactory and autonomic neurons. Involved in the initiation of neuronal differentiation. Mediates transcription activation by binding to the E box (5 -CANNTG-3 ). Protein type: Transcription factor; DNA-binding. Chromosomal Location of Human Ortholog: 12q23.2. Cellular Component: cell soma; nucleus. Molecular Function: protein binding; protein homodimerization activity; DNA binding; double-stranded DNA binding; bHLH transcription factor binding; chromatin binding; transcription factor activity. Biological Process: vestibular nucleus development; response to lithium ion; musculoskeletal movement, spinal reflex action; cell maturation; olfactory pit development; regulation of mitotic cell cycle; neuron migration; neuroblast fate determination; negative regulation of transcription from RNA polymerase II promoter; sympathetic nervous system development; response to folic acid; positive regulation of neuron apoptosis; neuron fate specification; oligodendrocyte development; positive regulation of Notch signaling pathway; central nervous system neuron development; Notch signaling pathway; response to retinoic acid; transcription, DNA-dependent; spinal cord oligodendrocyte cell fate specification; positive regulation of cell cycle; regulation of timing of subpallium neuron differentiation; cerebral cortex GABAergic interneuron differentiation; negative regulation of neuron differentiation; neurogenesis; subpallium neuron fate commitment; commitment of a neuronal cell to a specific type of neuron in the forebrain; regulation of gene expression; neuroblast proliferation; regulation of epithelial cell differentiation; spinal cord association neuron differentiation; positive regulation of transcription from RNA polymerase II promoter; cerebral cortex development; positive regulation of neuron differentiation; negative regulation of transcription, DNA-dependent; negative regulation of apoptosis. Disease: Central Hypoventilation Syndrome, Congenital

size1 :

48-Strip-Wells

price1 :

435 USD

size2 :

96-Strip-Wells

price2 :

600

more info or order :

MyBioSource product webpage