product summary
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company name :
MyBioSource
product type :
ELISA/assay
product name :
Human Transcription factor 7, TCF7 ELISA Kit
catalog :
MBS9320496
quantity :
48-Strip-Wells
price :
435 USD
more info or order :
MyBioSource product webpage
product information
catalog number :
MBS9320496
products type :
ELISA Kit
products full name :
Human Transcription factor 7, TCF7 ELISA Kit
products short name :
transcription factor 7 (T-cell specific, HMG-box)
products name syn :
Human Transcription factor 7 (TCF7) ELISA kit; FLJ36364; MGC47735; TCF-1; OTTHUMP00000159391; Transcription factor-7; T-cell specific; transcription factor 7 (T-cell specific; HMG-box)
other names :
transcription factor 7 isoform 3; Transcription factor 7; transcription factor 7; T-cell-specific transcription factor 1; transcription factor 7 (T-cell specific, HMG-box); T-cell-specific transcription factor 1; T-cell factor 1; TCF-1
products gene name :
TCF7
other gene names :
TCF7; TCF7; TCF-1; TCF1; TCF-7; T-cell factor 1; TCF-1
uniprot entry name :
TCF7_HUMAN
reactivity :
Human
specificity :
No significant cross-reactivity or interference between this analyte and analogues is observed.
storage stability :
Store all reagents at 2-8 degree C
other info1 :
Samples: Serum, Plasma and Tissue Homogenate. Assay Type: Sandwich. Detection Range: 31.2 pg/ml - 1000 pg/ml. Sensitivity: 5.0 pg/ml.
other info2 :
Intra-assay Precision: Intra-assay CV (%) is less than 15%. Inter-assay Precision: Inter-assay CV (%) is less than 15%. [CV(%) = SD/mean ×100].
products description :
Background: This Quantitative Sandwich ELISA kit is only for in vitro research use only, not for drug, household, therapeutic or diagnostic applications! This kit is intended to be used for determination the level of TCF7 (hereafter termed this analyte) in undiluted original Human serum, plasma and tissue homogenate samples.
ncbi gi num :
293651582
ncbi acc num :
NP_001128323.2
ncbi gb acc num :
NM_001134851.2
uniprot acc num :
P36402
ncbi mol weight :
41,642 Da
ncbi pathways :
Acute Myeloid Leukemia Pathway (83117); Acute Myeloid Leukemia Pathway (529); Adherens Junction Pathway (83070); Adherens Junction Pathway (481); Arrhythmogenic Right Ventricular Cardiomyopathy (ARVC) Pathway (117293); Arrhythmogenic Right Ventricular Cardiomyopathy (ARVC) Pathway (116129); Basal Cell Carcinoma Pathway (83113); Basal Cell Carcinoma Pathway (525); Colorectal Cancer Pathway (83106); Colorectal Cancer Pathway (518)
ncbi summary :
The protein encoded by this gene is a transcriptional activator that plays an important role in lymphocyte differentiation. This gene is expressed predominantly in T-cells. The encoded protein can bind an enhancer element and activate the CD3E gene, and it also may repress the CTNNB1 and TCF7L2 genes through a feedback mechanism. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]
uniprot summary :
TCF7: Transcriptional activator involved in T-cell lymphocyte differentiation. Necessary for the survival of CD4(+) CD8(+) immature thymocytes. Isoforms lacking the N-terminal CTNNB1 binding domain cannot fulfill this role. Binds to the T- lymphocyte-specific enhancer element (5 -WWCAAAG-3 ) found in the promoter of the CD3E gene. May also act as feedback transcriptional repressor of CTNNB1 and TCF7L2 target genes. TLE1, TLE2, TLE3 and TLE4 repress transactivation mediated by TCF7 and CTNNB1. Binds the armadillo repeat of CTNNB1 and forms a stable complex. Interacts with AES, TLE1, TLE2, TLE3 and TLE4. By TCF7L2 and CTNNB1. Predominantly expressed in T-cells. Also detected in proliferating intestinal epithelial cells and in the basal epithelial cells of mammary gland epithelium. Belongs to the TCF/LEF family. 16 isoforms of the human protein are produced by alternative promoter. Protein type: Transcription factor; DNA-binding. Chromosomal Location of Human Ortholog: 5q31.1. Cellular Component: nucleoplasm; transcription factor complex; nucleus. Molecular Function: protein binding; sequence-specific DNA binding; beta-catenin binding; chromatin binding; transcription factor activity. Biological Process: neural tube development; transcription, DNA-dependent; alpha-beta T cell differentiation; Wnt receptor signaling pathway through beta-catenin; regulation of cell proliferation; regulation of transcription from RNA polymerase II promoter; embryonic digestive tract morphogenesis; generation of neurons; T cell receptor V(D)J recombination; immune response; brain development; embryonic genitalia morphogenesis; embryonic hindgut morphogenesis
size1 :
48-Strip-Wells
price1 :
435 USD
size2 :
96-Strip-Wells
price2 :
600
more info or order :
MyBioSource product webpage
company information
MyBioSource
P.O. Box 153308
San Diego, CA 92195-3308
sales@mybiosource.com
https://www.mybiosource.com
1-888-627-0165
headquarters: USA
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