catalog number :
MBS9320334
products type :
ELISA Kit
products full name :
Human Metalloendopeptidase OMA1, mitochondrial, OMA1 ELISA Kit
products short name :
OMA1 homolog, zinc metallopeptidase (S. cerevisiae)
products name syn :
Human Metalloendopeptidase OMA1; mitochondrial (OMA1) ELISA kit; 2010001O09Rik; DAB1; FLJ33782; MPRP-1; YKR087C; ZMPOMA1; OMA1 homolog; zinc metallopeptidase; metalloprotease related protein 1; overlapping activity with M-AAA protease; OMA1 homolog; zinc metallopeptidase (S. cerevisiae)
other names :
metalloendopeptidase OMA1, mitochondrial; Metalloendopeptidase OMA1, mitochondrial; metalloendopeptidase OMA1, mitochondrial; zinc metallopeptidase OMA1; metalloprotease related protein 1; metalloprotease-related protein 1; OMA1 zinc metallopeptidase homolog; OMA1 homolog, zinc metallopeptidase; overlapping activity with M-AAA protease; overlapping with the m-AAA protease 1 homolog; OMA1 zinc metallopeptidase; Metalloprotease-related protein 1; MPRP-1; Overlapping with the m-AAA protease 1 homolog
products gene name :
OMA1
other gene names :
OMA1; OMA1; DAB1; MPRP-1; YKR087C; ZMPOMA1; peptidase; 2010001O09Rik; MPRP1; MPRP-1
uniprot entry name :
OMA1_HUMAN
storage stability :
Store all reagents at 2-8 degree C
ncbi acc num :
NP_660286.1
ncbi gb acc num :
NM_145243.3
ncbi mol weight :
60,120 Da
uniprot summary :
OMA1: Metalloprotease that is part of the quality control system in the inner membrane of mitochondria. Following stress conditions that induce loss of mitochondrial membrane potential, mediates cleavage of OPA1 at S1 position, leading to OPA1 inactivation and negative regulation of mitochondrial fusion. Its role in mitochondrial quality control is essential for regulating lipid metabolism as well as to maintain body temperature and energy expenditure under cold-stress conditions. Belongs to the peptidase M48 family. 2 isoforms of the human protein are produced by alternative splicing. Protein type: Membrane protein, multi-pass; Membrane protein, integral; EC 3.4.24.-; Protease. Chromosomal Location of Human Ortholog: 1p32.2-p32.1. Cellular Component: mitochondrial membrane; mitochondrial inner membrane; integral to membrane. Molecular Function: metalloendopeptidase activity; metal ion binding. Biological Process: diet induced thermogenesis; cristae formation; misfolded or incompletely synthesized protein catabolic process; glucose metabolic process; response to stress; lipid metabolic process