Human Gamma-aminobutyric acid type B receptor subunit 2, GABBR2 ELISA Kit | MyBioSource MBS9319824 product information

product summary

company name :

MyBioSource

product type :

ELISA/assay

product name :

Human Gamma-aminobutyric acid type B receptor subunit 2, GABBR2 ELISA Kit

catalog :

MBS9319824

quantity :

48-Strip-Wells

price :

470 USD

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS9319824

products type :

ELISA Kit

products full name :

Human Gamma-aminobutyric acid type B receptor subunit 2, GABBR2 ELISA Kit

products short name :

[gamma-aminobutyric acid (GABA) B receptor, 2]

products name syn :

[Human Gamma-aminobutyric acid type B receptor subunit 2 (GABBR2) ELISA kit; FLJ36928; GABABR2; GPR51; GPRC3B; HG20; HRIHFB2099; G protein-coupled receptor 51; gamma-aminobutyric acid (GABA) B receptor; 2]

other names :

[gamma-aminobutyric acid type B receptor subunit 2; Gamma-aminobutyric acid type B receptor subunit 2; gamma-aminobutyric acid type B receptor subunit 2; gb2; GABA-BR2; GABA-B-R2; GABA-B receptor 2; GABA-B receptor, R2 subunit; G protein-coupled receptor 51; G-protein coupled receptor 51; gamma-aminobutyric acid B receptor 2; gamma-aminobutyric acid (GABA) B receptor, 2; G-protein coupled receptor 51; HG20]

products gene name :

[GABBR2]

other gene names :

[GABBR2; GABBR2; HG20; GPR51; GPRC3B; GABABR2; HRIHFB2099; GPR51; GPRC3B; GABA-B receptor 2; GABA-B-R2; GABA-BR2; GABABR2; Gb2]

uniprot entry name :

GABR2_HUMAN

reactivity :

Human

specificity :

No significant cross-reactivity or interference between this analyte and analogues is observed.

storage stability :

Store all reagents at 2-8 degree C

other info1 :

Samples: undiluted original Human body fluids, tissue homogenates, secretions or feces samples. Assay Type: Quantitative Sandwich. Detection Range: 3.12 ng/ml - 100 ng/mL. Sensitivity: 1.0 ng/mL

other info2 :

Intra-assay Precision: Intra-assay CV (%) is less than 15%. Inter-assay Precision: Inter-assay CV (%) is less than 15%. [CV(%) = SD/mean ×100].

products description :

Background: This Quantitative Sandwich ELISA kit is only for in vitro research use only, not for drug, household, therapeutic or diagnostic applications! This kit is intended to be used for determination the level of GABBR2 (hereafter termed "analyte") in undiluted original Human body fluids, tissue homogenates, secretions or feces samples. This kit is NOT suitable for assaying non-biological sources of substances.

ncbi gi num :

40255245

ncbi acc num :

NP_005449.5

ncbi gb acc num :

NM_005458.7

uniprot acc num :

O75899

ncbi mol weight :

105,821 Da

ncbi pathways :

Activation Of G Protein Gated Potassium Channels Pathway (366226); Activation Of GABAB Receptors Pathway (187181); Class C/3 (Metabotropic Glutamate/pheromone Receptors) Pathway (106381); G Alpha (i) Signalling Events Pathway (119550); G Protein Gated Potassium Channels Pathway (366225); GABA B Receptor Activation Pathway (187180); GABA Receptor Activation Pathway (187178); GABAergic Synapse Pathway (377263); GABAergic Synapse Pathway (377129); GPCR Downstream Signaling Pathway (119548)

ncbi summary :

The multi-pass membrane protein encoded by this gene belongs to the G-protein coupled receptor 3 family and GABA-B receptor subfamily. The GABA-B receptors inhibit neuronal activity through G protein-coupled second-messenger systems, which regulate the release of neurotransmitters, and the activity of ion channels and adenylyl cyclase. This receptor subunit forms an active heterodimeric complex with GABA-B receptor subunit 1, neither of which is effective on its own. Allelic variants of this gene have been associated with nicotine dependence.[provided by RefSeq, Jan 2010]

uniprot summary :

GABBR2: Receptor for GABA. The activity of this receptor is mediated by G-proteins that inhibit adenylyl cyclase activity, stimulates phospholipase A2, activates potassium channels, inactivates voltage-dependent calcium-channels and modulates inositol phospholipids hydrolysis. Plays a critical role in the fine-tuning of inhibitory synaptic transmission. Pre-synaptic GABA-B-R inhibit neurotransmitter release by down-regulating high- voltage activated calcium channels, whereas postsynaptic GABA-B-R decrease neuronal excitability by activating a prominent inwardly rectifying potassium (Kir) conductance that underlies the late inhibitory postsynaptic potentials. Not only implicated in synaptic inhibition but also in hippocampal long-term potentiation, slow wave sleep, muscle relaxation and antinociception. Heterodimer of GABA-B-R1 and GABA-B-R2. Neither of which is effective on its own and homodimeric assembly does not seem to happen. Interacts with ATF4 via its C-terminal region. Highly expressed in brain, especially in cerebral cortex, thalamus, hippocampus, frontal, occipital and temporal lobe, occipital pole and cerebellum, followed by corpus callosum, caudate nucleus, spinal cord, amygdala and medulla. Weakly expressed in heart, testis and skeletal muscle. Belongs to the G-protein coupled receptor 3 family. GABA-B receptor subfamily. Protein type: Membrane protein, multi-pass; GPCR, family 3; Membrane protein, integral; Receptor, GPCR. Chromosomal Location of Human Ortholog: 9q22.1-q22.3. Cellular Component: postsynaptic membrane; neuron projection; integral to plasma membrane; cytoplasm; plasma membrane; cell junction. Molecular Function: protein binding; GABA-B receptor activity. Biological Process: G-protein coupled receptor protein signaling pathway; synaptic transmission; negative regulation of adenylate cyclase activity; gamma-aminobutyric acid signaling pathway. Disease: Tobacco Addiction, Susceptibility To

size1 :

48-Strip-Wells

price1 :

470 USD

size2 :

96-Strip-Wells

price2 :

680

size3 :

5x96-Strip-Wells

price3 :

3100

size4 :

10x96-Strip-Wells

price4 :

6095

more info or order :

MyBioSource product webpage