catalog number :
MBS9319731
products type :
ELISA Kit
products full name :
Mouse Non-receptor tyrosine-protein kinase TNK1, TNK1 ELISA Kit
products short name :
tyrosine kinase, non-receptor, 1
products name syn :
Mouse Non-receptor tyrosine-protein kinase TNK1 (TNK1) ELISA kit; MGC46193; ; tyrosine kinase; non-receptor; 1
other names :
non-receptor tyrosine-protein kinase TNK1; Non-receptor tyrosine-protein kinase TNK1; non-receptor tyrosine-protein kinase TNK1; non-receptor tyrosine kinase; kinase of embryonic stem cells; tyrosine kinase, non-receptor, 1; Kinase of embryonic stem cells
products gene name :
TNK1
other gene names :
Tnk1; Tnk1; Kos1; Tnk1a; Tnk1b; Kos1
uniprot entry name :
TNK1_MOUSE
specificity :
No significant cross-reactivity or interference between this analyte and analogues is observed.
storage stability :
Store all reagents at 2-8 degree C
other info1 :
Samples: Mouse body fluids, tissue homogenates, secretions or feces samples. This kit is NOT suitable for assaying non-biological sources of substances. Assay Type: Sandwich. Detection Range: 0.5 ng/ml - 16 ng/ml. Sensitivity: 0.1 ng/ml
other info2 :
Intra-assay Precision: Intra-assay CV (%) is less than 15%. Inter-assay Precision: Inter-assay CV (%) is less than 15%. [CV(%) = SD/mean ×100].
products description :
Background/Introduction: This Quantitative Sandwich ELISA kit is only for in vitro research use only, NOT for drug, household, therapeutic or diagnostic applications! This kit is intended to be used for determination the level of TNK1 (hereafter termed "analyte") in undiluted original Mouse body fluids, tissue homogenates, secretions or feces samples. This kit is NOT suitable for assaying non-biological sources of substances.
ncbi acc num :
NP_114086.3
ncbi gb acc num :
NM_031880.3
ncbi mol weight :
73,099 Da
ncbi pathways :
Focal Adhesion Pathway (198353)
uniprot summary :
TNK1: Involved in negative regulation of cell growth. Has tumor suppressor properties. Plays a negative regulatory role in the Ras-MAPK pathway. May function in signaling pathways utilized broadly during fetal development and more selectively in adult tissues and in cells of the lymphohematopoietic system. Could specifically be involved in phospholipid signal transduction. Interacts with the SH3 domain of PLCG1 via its Pro-rich domain. Expressed in all umbilical cord blood, bone marrow and adult blood cell sub-populations and in several leukemia cell lines. Highly expressed in fetal blood, brain, lung, liver and kidney. Detected at lower levels in adult prostate, testis, ovary, small intestine and colon. Not expressed in adult lung, liver, kidney or brain. Belongs to the protein kinase superfamily. Tyr protein kinase family. 2 isoforms of the human protein are produced by alternative splicing. Protein type: Protein kinase, TK; Protein kinase, tyrosine (non-receptor); EC 2.7.10.2; Kinase, protein; TK group; Ack family. Cellular Component: extrinsic to internal side of plasma membrane; membrane; cytoplasm; cytosol. Molecular Function: transferase activity; protein-tyrosine kinase activity; transferase activity, transferring phosphorus-containing groups; nucleotide binding; non-membrane spanning protein tyrosine kinase activity; kinase activity; ATP binding; protein kinase activity; hormone receptor binding. Biological Process: cell migration; peptidyl-tyrosine phosphorylation; protein amino acid autophosphorylation; innate immune response; negative regulation of Ras protein signal transduction; negative regulation of cell growth; cell differentiation; protein amino acid phosphorylation; phosphorylation; transmembrane receptor protein tyrosine kinase signaling pathway; regulation of cell proliferation