ELISA/assay

Human Inverted formin-2, INF2 ELISA Kit

MBS9319288

48-Strip-Wells

470 USD

ELISA Kit

Human Inverted formin-2, INF2 ELISA Kit

[inverted formin, FH2 and WH2 domain containing]

[Human Inverted formin-2 (INF2) ELISA kit; hCG_2029577; C14orf151; C14orf173; DKFZp762A0214; FLJ22056; MGC13251; pp9484; inverted formin 2; inverted formin; FH2 and WH2 domain containing]

[inverted formin-2 isoform 2; Inverted formin-2; inverted formin-2; HBEBP2-binding protein C; HBEAG-binding protein 2 binding protein C; inverted formin, FH2 and WH2 domain containing; HBEBP2-binding protein C]

[INF2]

[INF2; INF2; FSGS5; CMTDIE; pp9484; C14orf151; C14orf173; C14orf151; C14orf173]

INF2_HUMAN

Human

No significant cross-reactivity or interference between this analyte and analogues is observed.

Store all reagents at 2-8 degree C

Assay Type: Quantitative Sandwich. Detection Range: 0.25 ng/ml - 8 ng/ml. Sensitivity: 0.1 ng/ml.

Intra-assay Precision: Intra-assay CV (%) is less than 15%. Inter-assay Precision: Inter-assay CV (%) is less than 15%. [CV(%) = SD/mean ×100].

Background: This Quantitative Sandwich ELISA kit is only for in vitro research use only, not for drug, household, therapeutic or diagnostic applications! This kit is intended to be used for determination the level of INF2 (hereafter termed "analyte") in undiluted original Human body fluids, tissue homogenates, secretions or feces samples. This kit is NOT suitable for assaying non-biological sources of substances.

149999378

NP_001026884.3

NM_001031714.3

Q27J81

135,624 Da

This gene represents a member of the formin family of proteins. It is considered a diaphanous formin due to the presence of a diaphanous inhibitory domain located at the N-terminus of the encoded protein. Studies of a similar mouse protein indicate that the protein encoded by this locus may function in polymerization and depolymerization of actin filaments. Mutations at this locus have been associated with focal segmental glomerulosclerosis 5.[provided by RefSeq, Aug 2010]

INF2: Severs actin filaments and accelerates their polymerization and depolymerization. Defects in INF2 are the cause of focal segmental glomerulosclerosis type 5 (FSGS5). A renal pathology defined by the presence of segmental sclerosis in glomeruli and resulting in proteinuria, reduced glomerular filtration rate and edema. Renal insufficiency often progresses to end-stage renal disease, a highly morbid state requiring either dialysis therapy or kidney transplantation. Defects in INF2 are the cause of Charcot-Marie-Tooth disease, dominant intermediate type E (CMTDIE). A form of Charcot-Marie-Tooth disease, a disorder of the peripheral nervous system, characterized by progressive weakness and atrophy, initially of the peroneal muscles and later of the distal muscles of the arms. The dominant intermediate type E is characterized by clinical and pathologic features intermediate between demyelinating and axonal peripheral neuropathies, and motor median nerve conduction velocities ranging from 25 to 45 m/sec. Patients additionally manifest focal segmental glomerulonephritis, proteinuria, progression to end- stage renal disease, and a characteristic histologic pattern on renal biopsy. Belongs to the formin homology family. 3 isoforms of the human protein are produced by alternative splicing. Protein type: Unknown function. Chromosomal Location of Human Ortholog: 14q32.33. Cellular Component: endoplasmic reticulum; perinuclear region of cytoplasm; cytoplasm; nucleus. Molecular Function: Rho GTPase binding; actin binding. Biological Process: regulation of cellular component size; actin cytoskeleton organization and biogenesis. Disease: Focal Segmental Glomerulosclerosis 5; Charcot-marie-tooth Disease, Dominant Intermediate E

48-Strip-Wells

470 USD

96-Strip-Wells

680

5x96-Strip-Wells

3100

10x96-Strip-Wells

6095