Human Induced myeloid leukemia cell differentiation protein Mcl-1, MCL1 ELISA Kit | MyBioSource MBS9319125 product information

product summary

company name :

MyBioSource

product type :

ELISA/assay

product name :

Human Induced myeloid leukemia cell differentiation protein Mcl-1, MCL1 ELISA Kit

catalog :

MBS9319125

quantity :

48-Strip-Wells

price :

435 USD

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS9319125

products type :

ELISA Kit

products full name :

Human Induced myeloid leukemia cell differentiation protein Mcl-1, MCL1 ELISA Kit

products short name :

myeloid cell leukemia sequence 1 (BCL2-related)

products name syn :

Human Induced myeloid leukemia cell differentiation protein Mcl-1 (MCL1) ELISA kit; BCL2L3; EAT; MCL1L; MCL1S; MGC104264; MGC1839; Mcl-1; TM; induced myeloid leukemia cell differentiation protein Mcl-1; myeloid cell leukemia ES; myeloid cell leukemia sequence 1; myeloid cell leukemia; myeloid cell leukemia sequence 1 (BCL2-related)

other names :

induced myeloid leukemia cell differentiation protein Mcl-1 isoform 3; Induced myeloid leukemia cell differentiation protein Mcl-1; induced myeloid leukemia cell differentiation protein Mcl-1; bcl-2-like protein 3; myeloid cell leukemia ES; bcl-2-related protein EAT/mcl1; myeloid cell leukemia sequence 1 (BCL2-related); myeloid cell leukemia 1; Bcl-2-like protein 3; Bcl2-L-3; Bcl-2-related protein EAT/mcl1; mcl1/EAT

products gene name :

MCL1

other gene names :

MCL1; MCL1; TM; EAT; MCL1L; MCL1S; Mcl-1; BCL2L3; MCL1-ES; bcl2-L-3; mcl1/EAT; BCL2L3; Bcl2-L-3

uniprot entry name :

MCL1_HUMAN

reactivity :

Human

specificity :

No significant cross-reactivity or interference between Human MCL1 and analogues was observed.

storage stability :

Store all reagents at 2-8 degree C

other info1 :

Samples: Serum, Plasma, Tissue Homogenate, Feces and Urine. Assay Type: Sandwich. Detection Range: 0.625 ng/ml - 20 ng/ml. Sensitivity: 0.1 ng/ml.

other info2 :

Intra-assay Precision: Intra-assay CV (%) is less than 15%. Inter-assay Precision: Inter-assay CV (%) is less than 15%. [CV(%) = SD/mean ×100].

products description :

Intended Uses: This Quantitative Sandwich ELISA kit is only for in vitro research use only, not for drug, household, therapeutic or diagnostic applications! It is intended to be determinated MCL1 concentrations in Human serum, plasma and other body fluids. Using Purified Human MCL1 antibody to coat Microelisa Stripplate wells to make solid-phase antibody, then add MCL1 and MCL1 antibody which has been labeled with HRP to wells, then the reactants become antibody-antigen-antibody-enzyme complex, after washing completely, add TMB substrate solution, TMB substrate becomes blue color under HRP enzyme-catalyzed, reaction is terminated by the addition of a sulphuric acid solution and the color change is measured spectrophotometrically at a wavelength of 450 nm. The concentration of MCL1 in the samples is then determined by comparing the O.D. of the samples to the standard curve.

ncbi gi num :

309747067

ncbi acc num :

NP_001184249.1

ncbi gb acc num :

NM_001197320.1

uniprot acc num :

Q07820

ncbi mol weight :

37,337 Da

ncbi pathways :

Apoptosis Pathway (198797); Direct P53 Effectors Pathway (137939); E2F Transcription Factor Network Pathway (137934); HIF-1-alpha Transcription Factor Network Pathway (138045); IL-7 Signaling Pathway (198857); IL6-mediated Signaling Events Pathway (137932)

ncbi summary :

This gene encodes an anti-apoptotic protein, which is a member of the Bcl-2 family. Alternative splicing results in multiple transcript variants. The longest gene product (isoform 1) enhances cell survival by inhibiting apoptosis while the alternatively spliced shorter gene products (isoform 2 and isoform 3) promote apoptosis and are death-inducing. [provided by RefSeq, Oct 2010]

uniprot summary :

MCL1: a myeloid cell leukemia protein of the Bcl-2 family of proteins. Two alternatively spliced transcripts encoding distinct isoforms have been identified. The longer gene product (isoform 1) enhances cell survival by inhibiting apoptosis while the alternatively spliced shorter gene product (isoform 2) promotes apoptosis and is death-inducing. Protein type: Mitochondrial; Channel, misc.; Membrane protein, integral; Inhibitor; Apoptosis. Chromosomal Location of Human Ortholog: 1q21. Cellular Component: nucleoplasm; mitochondrial outer membrane; mitochondrion; membrane; mitochondrial matrix; cytoplasm; integral to membrane; cytosol; nucleus. Molecular Function: protein binding; protein homodimerization activity; protein heterodimerization activity; protein channel activity; BH3 domain binding. Biological Process: apoptotic mitochondrial changes; DNA damage response, signal transduction resulting in induction of apoptosis; multicellular organismal development; response to cytokine stimulus; cell fate determination; cellular homeostasis

size1 :

48-Strip-Wells

price1 :

435 USD

size2 :

96-Strip-Wells

price2 :

600

more info or order :

MyBioSource product webpage