ELISA/assay

Human Dynamin-like 120 kDa protein, mitochondrial, OPA1 ELISA Kit

MBS9319015

48-Strip-Wells

470 USD

ELISA Kit

Human Dynamin-like 120 kDa protein, mitochondrial, OPA1 ELISA Kit

[optic atrophy 1 (autosomal dominant)]

[Human Dynamin-like 120 kDa protein; mitochondrial (OPA1) ELISA kit; FLJ12460; KIAA0567; MGM1; NPG; NTG; largeG; mitochondrial dynamin-like GTPase; optic atrophy 1; optic atrophy 1 (autosomal dominant)]

[dynamin-like 120 kDa protein, mitochondrial isoform 1; Dynamin-like 120 kDa protein, mitochondrial; dynamin-like 120 kDa protein, mitochondrial; optic atrophy protein 1; mitochondrial dynamin-like GTPase; dynamin-like guanosine triphosphatase; optic atrophy 1 (autosomal dominant); Optic atrophy protein 1Cleaved into the following chain:Dynamin-like 120 kDa protein, form S1]

[OPA1]

[OPA1; OPA1; NPG; NTG; MGM1; largeG; KIAA0567]

OPA1_HUMAN

Human

No significant cross-reactivity or interference between this analyte and analogues is observed.

Store all reagents at 2-8 degree C

Samples: Human body fluids, tissue homogenates, secretions or feces samples. This kit is NOT suitable for assaying non-biological sources of substances. Assay Type: Sandwich. Detection Range: 0.5 ng/ml - 16 ng/ml. Sensitivity: 0.1 ng/ml

Intra-assay Precision: Intra-assay CV (%) is less than 15%. Inter-assay Precision: Inter-assay CV (%) is less than 15%. [CV(%) = SD/mean ×100].

Background/Introduction: This Quantitative Sandwich ELISA kit is only for in vitro research use only, NOT for drug, household, therapeutic or diagnostic applications! This kit is intended to be used for determination the level of OPA1 (hereafter termed "analyte") in undiluted original Human body fluids, tissue homogenates, secretions or feces samples. This kit is NOT suitable for assaying non-biological sources of substances.

224831243

NP_056375.2

NM_015560.2

O60313

111,631 Da

This gene product is a nuclear-encoded mitochondrial protein with similarity to dynamin-related GTPases. It is a component of the mitochondrial network. Mutations in this gene have been associated with optic atrophy type 1, which is a dominantly inherited optic neuropathy resulting in progressive loss of visual acuity, leading in many cases to legal blindness. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2009]

OPA1: a dynamin-related GTPase required for mitochondrial fusion and regulation of apoptosis. May form a diffusion barrier for proteins stored in mitochondrial cristae. Proteolytic processing in response to intrinsic apoptotic signals may lead to disassembly of OPA1 oligomers and release of the caspase activator cytochrome C (CYCS) into the mitochondrial intermembrane space. Defects in OPA1 are the cause of optic atrophy 1 and deafness. Eight splice-variant isoforms have been described. Protein type: Apoptosis; Mitochondrial; EC 3.6.5.5; Membrane protein, integral; Hydrolase. Chromosomal Location of Human Ortholog: 3q29. Cellular Component: nucleoplasm; mitochondrial outer membrane; mitochondrial crista; membrane; mitochondrion; dendrite; cytoplasm; mitochondrial inner membrane; integral to membrane; mitochondrial intermembrane space. Molecular Function: GTPase activity; protein binding; GTP binding; magnesium ion binding. Biological Process: inner mitochondrial membrane organization and biogenesis; mitochondrion organization and biogenesis; mitochondrial fission; mitochondrial genome maintenance; axon transport of mitochondrion; mitochondrial fusion; visual perception; metabolic process; apoptosis; neural tube closure. Disease: Glaucoma, Normal Tension, Susceptibility To; Optic Atrophy With Or Without Deafness, Ophthalmoplegia, Myopathy, Ataxia, And Neuropathy; Optic Atrophy 1

48-Strip-Wells

470 USD

96-Strip-Wells

680

5x96-Strip-Wells

3100

10x96-Strip-Wells

6095