ELISA/assay

Mouse Tyrosine-protein kinase ABL1, ABL1 ELISA Kit

MBS9318773

48-Strip-Wells

470 USD

ELISA Kit

Mouse Tyrosine-protein kinase ABL1, ABL1 ELISA Kit

[c-abl oncogene 1, receptor tyrosine kinase]

[Mouse Tyrosine-protein kinase ABL1 (ABL1) ELISA kit; RP11-83J21.1; ABL; JTK7; bcr/abl; c-ABL; p150; v-abl; bcr/c-abl oncogene protein; proto-oncogene tyrosine-protein kinase ABL1; v-abl Abelson murine leukemia viral oncogene homolog 1; c-abl oncogene 1; receptor tyrosine kinase]

[tyrosine-protein kinase ABL1 isoform a; Tyrosine-protein kinase ABL1; tyrosine-protein kinase ABL1; p150; proto-oncogene c-Abl; Abelson murine leukemia oncogene; Abelson tyrosine-protein kinase 1; v-abl Abelson murine leukemia oncogene 1; c-abl oncogene 1, receptor tyrosine kinase; proto-oncogene tyrosine-protein kinase ABL1; abelson murine leukemia viral oncogene homolog 1; c-abl oncogene 1, non-receptor tyrosine kinase; Abelson murine leukemia viral oncogene homolog 1; Abelson tyrosine-protein kinase 1; Proto-oncogene c-Abl; p150]

[ABL1]

[Abl1; Abl1; Abl; c-Abl; AI325092; E430008G22Rik; Abl]

ABL1_MOUSE

Mouse

No significant cross-reactivity or interference between this analyte and analogues is observed.

Store all reagents at 2-8 degree C

Samples: Human Body Fluids And Tissue Homogenates. Assay Type: Quantitative Sandwich. Detection Range: 3.12ng/ml-100ng/ml.

Intra-assay Precision: Intra-assay CV (%) are less than 15%. Inter-assay Precision: Inter-assay CV (?) are less than 15%. [CV(%) = SD/mean ×100]. All CV% should be compared by concentration, not compared by OD values.

Background/Introduction: This Quantitative Sandwich ELISA kit is for lab reagent/research use only, not for drug, household, therapeutic or diagnostic applications! This kit is intended to be used for determine the level of ABI3BP (hereafter termed "analyte") in undiluted original Human body fluids and tissue homogenates. This kit is NOT suitable for assaying non-biological sources of substances.

162951870

NP_001106174.1

NM_001112703.2

P00520

122,673 Da

Alpha6-Beta4 Integrin Signaling Pathway (198373); Axon Guidance Pathway (83262); Axon Guidance Pathway (476); Axon Guidance Pathway (575211); Cell Cycle Pathway (83251); Cell Cycle Pathway (198407); Cell Cycle Pathway (463); Cell Cycle Signaling Pathway (522974); Chronic Myeloid Leukemia Pathway (83309); Chronic Myeloid Leukemia Pathway (528)

Abl: an ubiquitously expressed and highly conserved proto-oncogenic tyrosine kinase. c-Abl protein is distributed in both the nucleus and the cytoplasm of cells. Negatively regulated by its SH3 domain, and deletion of the SH3 domain turns ABL1 into an oncogene. It has been implicated in regulation of cell proliferation, differentiation, apoptosis, cell adhesion and stress response. The Philadephia chromosome translocation t(9;22)(q34;q11) creates a Bcr-Abl fusion protein, responsible for 90% of chronic myelogenous leukemia (CML) and ~25% of acute lymphoblastic leukemia (ALL). Inhibitors: Gleevec (imatinib, Glivec), Dasatinib. Two alternatively-spliced isoforms have been described. Protein type: EC 2.7.10.2; Protein kinase, TK; Oncoprotein; Kinase, protein; Protein kinase, tyrosine (non-receptor); TK group; Abl family. Cellular Component: neuron projection; mitochondrion; endoplasmic reticulum; leading edge; cytosol; actin cytoskeleton; nucleoplasm; ruffle; extrinsic to internal side of plasma membrane; growth cone; cytoskeleton; cell soma; perinuclear region of cytoplasm; cytoplasm; nucleolus; synapse; nucleus. Molecular Function: protein C-terminus binding; protein domain specific binding; metal ion binding; nucleotide binding; magnesium ion binding; non-membrane spanning protein tyrosine kinase activity; protein kinase binding; protein kinase activity; transferase activity; actin filament binding; protein binding; syntaxin binding; DNA binding; protein-tyrosine kinase activity; manganese ion binding; transferase activity, transferring phosphorus-containing groups; mitogen-activated protein kinase binding; kinase activity; SH3 domain binding; ATP binding; receptor binding. Biological Process: B cell proliferation; peptidyl-tyrosine phosphorylation; DNA damage induced protein phosphorylation; regulation of cell cycle; apoptosis; positive regulation of apoptosis; cerebellum morphogenesis; alpha-beta T cell differentiation; platelet-derived growth factor receptor signaling pathway; positive regulation of mitotic cell cycle; protein amino acid phosphorylation; negative regulation of BMP signaling pathway; Bergmann glial cell differentiation; transitional one stage B cell differentiation; B cell receptor signaling pathway; elevation of cytosolic calcium ion concentration; collateral sprouting; negative regulation of mitotic cell cycle; neuromuscular process controlling balance; cell adhesion; positive regulation of oxidoreductase activity; B cell proliferation during immune response; epidermal growth factor receptor signaling pathway; spleen development; cell migration; positive regulation of I-kappaB kinase/NF-kappaB cascade; thymus development; DNA damage response, signal transduction; activated T cell proliferation; B-1 B cell homeostasis; endocytosis; negative regulation of I-kappaB kinase/NF-kappaB cascade; DNA repair; phagocytosis; positive regulation of peptidyl-tyrosine phosphorylation; regulation of actin cytoskeleton organization and biogenesis; microspike biogenesis; positive regulation of osteoblast proliferation; negative regulation of ubiquitin-protein ligase activity; autophagy; innate immune response; negative regulation of cell-cell adhesion; response to oxidative stress; positive regulation of release of sequestered calcium ion into cytosol; actin cytoskeleton organization and biogenesis; phosphorylation; response to DNA damage stimulus

48-Strip-Wells

470 USD

96-Strip-Wells

680

5x96-Strip-Wells

3100

10x96-Strip-Wells

6095