ELISA/assay

Human MAP kinase-activated protein kinase 5, MAPKAPK5 ELISA Kit

MBS9318402

48-Strip-Wells

470 USD

ELISA Kit

Human MAP kinase-activated protein kinase 5, MAPKAPK5 ELISA Kit

[mitogen-activated protein kinase-activated protein kinase 5]

[Human MAP kinase-activated protein kinase 5 (MAPKAPK5) ELISA kit; PRAK; MAP kinase-activated protein kinase 5; p38-regulated/activated protein kinase; mitogen-activated protein kinase-activated protein kinase 5]

[MAP kinase-activated protein kinase 5 isoform 1; MAP kinase-activated protein kinase 5; MAP kinase-activated protein kinase 5; MAPKAPK-5; MAPKAP kinase 5; MAPK-activated protein kinase 5; p38-regulated/activated protein kinase; mitogen-activated protein kinase-activated protein kinase 5; p38-regulated/activated protein kinase; PRAK]

[MAPKAPK5]

[MAPKAPK5; MAPKAPK5; MK5; MK-5; PRAK; MAPKAP-K5; PRAK; MAPK-activated protein kinase 5; MAPKAP kinase 5; MAPKAP-K5; MAPKAPK-5; MK-5; MK5; PRAK]

MAPK5_HUMAN

Human

No significant cross-reactivity or interference between this analyte and analogues is observed.

Store all reagents at 2-8 degree C

Samples: Human Serum, Plasma Or Tissue Homogenates Samples. Assay Type: Quantitative Sandwich. Detection Range: 3.12ng/ml-100ng/ml. Sensitivity: 1.0ng/ml.

Intra-assay Precision: Intra-assay CV (%) is less than 15%. Inter-assay Precision: Inter-assay CV (%) is less than 15%. [CV(%) = SD/mean ×100]. All CV% should be compared by concentration, not compared by OD values.

Background/Introduction: This Quantitative Sandwich ELISA kit is for lab reagent/research use only, not for drug, household, therapeutic or diagnostic applications! This kit is intended to be used for determine the level of MAPK8 (hereafter termed "analyte") in undiluted original Human serum, plasma or tissue homogenates samples. For other sample types please contact tech support to determine compatibility with this assay. This kit is not suitable for assaying non-biological sources of substances.

21237765

NP_003659.2

NM_003668.3

Q8IW41

54,220 Da

MAPK Signaling Pathway (198779); MAPK Signaling Pathway (83048); MAPK Signaling Pathway (456); Signaling Mediated By P38-alpha And P38-beta Pathway (138012); P38 MAPK Signaling Pathway (198893)

The protein encoded by this gene is a tumor suppressor and member of the serine/threonine kinase family. In response to cellular stress and proinflammatory cytokines, this kinase is activated through its phosphorylation by MAP kinases including MAPK1/ERK, MAPK14/p38-alpha, and MAPK11/p38-beta. The encoded protein is found in the nucleus but translocates to the cytoplasm upon phosphorylation and activation. This kinase phosphorylates heat shock protein HSP27 at its physiologically relevant sites. Two alternately spliced transcript variants of this gene encoding distinct isoforms have been reported. [provided by RefSeq, Nov 2012]

MAPKAPK5: a member of the MAPKAPK family of protein kinases. Activated through phosphorylation by MAP kinases including ERK, p38-alpha, and MAPp38-beta In response to cellular stress and proinflammatory cytokines. Two alternately spliced transcript variants of this gene encoding distinct isoforms have been reported. Protein type: Protein kinase, CAMK; Tumor suppressor; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); EC 2.7.11.1; CAMK group; MAPKAPK family; MAPKAPK subfamily. Chromosomal Location of Human Ortholog: 12q24.13. Cellular Component: nucleoplasm; cytoplasm. Molecular Function: MAP kinase kinase activity; protein serine/threonine kinase activity; protein binding; p53 binding; mitogen-activated protein kinase binding; ATP binding. Biological Process: regulation of translation; negative regulation of TOR signaling pathway; activation of MAPK activity; protein amino acid autophosphorylation; Ras protein signal transduction; MAPKKK cascade; signal transduction

48-Strip-Wells

470 USD

96-Strip-Wells

680

5x96-Strip-Wells

3100

10x96-Strip-Wells

6095