catalog number :
MBS9318316
products type :
ELISA Kit
products full name :
Human Phosphatidylinositol 3, 4, 5-trisphosphate-dependent Rac exchanger 1 protein, PREX1 ELISA Kit
products short name :
phosphatidylinositol-3, 4, 5-trisphosphate-dependent Rac exchange factor 1
products name syn :
Human Phosphatidylinositol 3; 4; 5-trisphosphate-dependent Rac exchanger 1 protein (PREX1) ELISA kit; KIAA1415; P-REX1; phosphatidylinositol 3; 4; 5-trisphosphate-dependent Rac exchanger 1; phosphatidylinositol-3; 4; 5-trisphosphate-dependent Rac exchange factor 1
other names :
phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein; Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein; phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein; ptdIns(3,4,5)-dependent Rac exchanger 1; phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 1
products gene name :
PREX1
other gene names :
PREX1; PREX1; P-REX1; KIAA1415; P-Rex1; PtdIns(3,4,5)-dependent Rac exchanger 1
uniprot entry name :
PREX1_HUMAN
ncbi acc num :
NP_065871.2
ncbi gb acc num :
NM_020820.3
ncbi mol weight :
186,203 Da
ncbi pathways :
Cell Death Signalling Via NRAGE, NRIF And NADE Pathway 106443!!Chemokine Signaling Pathway 99051!!Chemokine Signaling Pathway 96864!!Class I PI3K Signaling Events Pathway 138022!!G Alpha (12/13) Signalling Events Pathway 106041!!GPCR Downstream Signaling Pathway 119548!!NRAGE Signals Death Through JNK Pathway 106444!!Regulation Of RAC1 Activity Pathway 169346!!Rho GTPase Cycle Pathway 106503!!Signal Transduction Pathway 477114
ncbi summary :
The protein encoded by this gene acts as a guanine nucleotide exchange factor for the RHO family of small GTP-binding proteins (RACs). It has been shown to bind to and activate RAC1 by exchanging bound GDP for free GTP. The encoded protein, which is found mainly in the cytoplasm, is activated by phosphatidylinositol-3,4,5-trisphosphate and the beta-gamma subunits of heterotrimeric G proteins. [provided by RefSeq, Jul 2008]
uniprot summary :
Function: Functions as a RAC guanine nucleotide exchange factor (GEF), which activates the Rac proteins by exchanging bound GDP for free GTP. Its activity is synergistically activated by phosphatidylinositol 3,4,5-trisphosphate and the beta gamma subunits of heterotrimeric G protein. May function downstream of heterotrimeric G proteins in neutrophils.