catalog number :
MBS9318089
products type :
ELISA Kit
products full name :
Human Bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 1, NDST1 ELISA Kit
products short name :
N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 1
products name syn :
Human Bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 1 (NDST1) ELISA kit; HSST; NST1; N-deacetylase/N-sulfotransferase 1; heparan sulfate-N-deacetylase/N-sulfotransferase; N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 1
other names :
bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 1 isoform 1; Bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 1; bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 1; NDST-1; HSNST 1; N-HSST 1; N-heparan sulfate sulfotransferase 1; glucosaminyl N-deacetylase/N-sulfotransferase 1; heparan sulfate-N-deacetylase/N-sulfotransferase; [Heparan sulfate]-glucosamine N-sulfotransferase 1; N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 1; Glucosaminyl N-deacetylase/N-sulfotransferase 1; NDST-1; N-heparan sulfate sulfotransferase 1; N-HSST 1; [Heparan sulfate]-glucosamine N-sulfotransferase 1; HSNST 1
products gene name :
NDST1
other gene names :
NDST1; NDST1; HSST; NST1; HSST; HSST1; NDST-1; N-HSST 1; HSNST 1
uniprot entry name :
NDST1_HUMAN
ncbi acc num :
NP_001534.1
ncbi gb acc num :
NM_001543.4
ncbi mol weight :
100,868 Da
ncbi pathways :
Glycosaminoglycan Biosynthesis - Heparan Sulfate Pathway 82984!!Glycosaminoglycan Biosynthesis - Heparan Sulfate Pathway 358!!Glycosaminoglycan Biosynthesis, Heparan Sulfate Backbone Pathway 413365!!Glycosaminoglycan Biosynthesis, Heparan Sulfate Backbone Pathway 468252!!Heparan Sulfate Biosynthesis Pathway 545278!!Heparan Sulfate Biosynthesis Pathway 545407!!Heparan Sulfate Biosynthesis (late Stages) Pathway 545274!!Heparan Sulfate Biosynthesis (late Stages) Pathway 545406
uniprot summary :
Function: Essential bifunctional enzyme that catalyzes both the N-deacetylation and the N-sulfation of glucosamine (GlcNAc) of the glycosaminoglycan in heparan sulfate. Modifies the GlcNAc-GlcA disaccharide repeating sugar backbone to make N-sulfated heparosan, a prerequisite substrate for later modifications in heparin biosynthesis. Plays a role in determining the extent and pattern of sulfation of heparan sulfate. Compared to other NDST enzymes, its presence is absolutely required. Participates in biosynthesis of heparan sulfate that can ultimately serve as L-selectin ligands, thereby playing a role in inflammatory response.2 PublicationsManual assertion based on experiment in:Ref.6. Catalytic activity: 3'-phosphoadenylyl sulfate + [heparan sulfate]-glucosamine = adenosine 3',5'-bisphosphate + [heparan sulfate]-N-sulfoglucosamine.