ELISA/assay

Human Dynein assembly factor 1, axonemal, LRRC50 ELISA Kit

MBS9317767

48-Strip-Wells

470 USD

ELISA Kit

Human Dynein assembly factor 1, axonemal, LRRC50 ELISA Kit

[leucine rich repeat containing 50]

[Human Dynein assembly factor 1; axonemal (LRRC50) ELISA kit; DKFZp434A119; FLJ25330; ODA7; outer row dynein assembly 7 homolog; leucine rich repeat containing 50]

[dynein assembly factor 1, axonemal; Dynein assembly factor 1, axonemal; dynein assembly factor 1, axonemal; leucine rich repeat containing 50; outer row dynein assembly 7 homolog; leucine-rich repeat-containing protein 50; dynein, axonemal, assembly factor 1; Leucine-rich repeat-containing protein 50]

[LRRC50]

[DNAAF1; DNAAF1; ODA7; CILD13; LRRC50; LRRC50]

DAAF1_HUMAN

Human

No significant cross-reactivity or interference between this analyte and analogues is observed.

Store all reagents at 2-8 degree C

Assay Type: Quantitative Sandwich. Detection Range: 3.12 ng/ml - 100 ng/ml. Sensitivity: 1.0 ng/ml

Intra-assay Precision: Intra-assay CV(%) is less than 15%. Inter-assay Precision: Inter-assay CV (%) is less than 15%. [CV(%) = SD/mean ×100].

Background: This Quantitative Sandwich ELISA kit is only for in vitro research use only, not for drug, household, therapeutic or diagnostic applications! This kit is intended to be used for determination the level of LRRC50 (hereafter termed "analyte") in undiluted original Human body fluids, tissue homogenates, secretions or feces samples. This kit is NOT suitable for assaying non-biological sources of substances.

157674358

NP_848547.4

NM_178452.4

Q8NEP3

80,026 Da

The protein encoded by this gene is cilium-specific and is required for the stability of the ciliary architecture. It is involved in the regulation of microtubule-based cilia and actin-based brush border microvilli. Mutations in this gene are associated with primary ciliary dyskinesia-13.[provided by RefSeq, May 2010]

LRRC50: Cilium-specific protein required for the stability of the ciliary architecture. Plays a role in cytoplasmic preassembly of dynein arms. Involved in regulation of microtubule-based cilia and actin-based brush border microvilli. Defects in DNAAF1 are the cause of primary ciliary dyskinesia type 13 (CILD13). A disorder characterized by abnormalities of motile cilia. Respiratory infections leading to chronic inflammation and bronchiectasis are recurrent, due to defects in the respiratory cilia; reduced fertility is often observed in male patients due to abnormalities of sperm tails. Half of the patients exhibit randomization of left-right body asymmetry and situs inversus, due to dysfunction of monocilia at the embryonic node. Primary ciliary dyskinesia associated with situs inversus is referred to as Kartagener syndrome. At ultrastructural level, CILD13 is characterized by a marked reduction or absence of both dynein arms from the cilia. Belongs to the DNAAF1 family. 3 isoforms of the human protein are produced by alternative splicing. Chromosomal Location of Human Ortholog: 16q24.1. Cellular Component: spindle pole; cytoplasm; plasma membrane; axoneme; nucleus. Molecular Function: dynein binding. Biological Process: heart looping; lung development. Disease: Ciliary Dyskinesia, Primary, 13

48-Strip-Wells

470 USD

96-Strip-Wells

680

5x96-Strip-Wells

3100

10x96-Strip-Wells

6095