Human Methylcytosine dioxygenase TET2, TET2 ELISA Kit | MyBioSource MBS9317739 product information

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product summary

company name :

MyBioSource

product type :

ELISA/assay

product name :

Human Methylcytosine dioxygenase TET2, TET2 ELISA Kit

catalog :

MBS9317739

quantity :

48-Strip-Wells

price :

470 USD

product information

catalog number :

MBS9317739

products type :

ELISA Kit

products full name :

Human Methylcytosine dioxygenase TET2, TET2 ELISA Kit

products short name :

[tet oncogene family member 2]

products name syn :

[Human Methylcytosine dioxygenase TET2 (TET2) ELISA kit; FLJ20032; KIAA1546; MGC125715; OTTHUMP00000161869; tet oncogene family member 2]

other names :

[methylcytosine dioxygenase TET2 isoform a; Methylcytosine dioxygenase TET2; methylcytosine dioxygenase TET2; tet oncogene family member 2; probable methylcytosine dioxygenase TET2; tet methylcytosine dioxygenase 2]

products gene name :

[TET2]

other gene names :

[TET2; TET2; MDS; KIAA1546; KIAA1546; Nbla00191]

uniprot entry name :

TET2_HUMAN

reactivity :

Human

specificity :

No significant cross-reactivity or interference between this analyte and analogues is observed.

storage stability :

Store all reagents at 2-8 degree C

other info1 :

Samples: Body fluids, tissue homogenates, secretions or feces samples. Assay Type: Quantitative Sandwich. Detection Range: 0.625 ng/ml - 20 ng/ml. Sensitivity: 0.1 ng/ml.

other info2 :

Intra-assay Precision: Intra-assay CV (%) is less than 15%. Inter-assay Precision: Inter-assay CV (%) is less than 15%. [CV(%) = SD/mean ×100].

products description :

Background/Introduction: This Quantitative Sandwich ELISA kit is only for in vitro research use only, not for drug, household, therapeutic or diagnostic applications! This kit is intended to be used for determination the level of TET2 (hereafter termed "analyte") in undiluted original Human body fluids, tissue homogenates, secretions or feces samples. This kit is NOT suitable for assaying non-biological sources of substances.

ncbi gi num :

187761317

ncbi acc num :

NP_001120680.1

ncbi gb acc num :

NM_001127208.2

uniprot acc num :

Q6N021

ncbi mol weight :

223,811 Da

ncbi summary :

The protein encoded by this gene is a methylcytosine dioxygenase that catalyzes the conversion of methylcytosine to 5-hydroxymethylcytosine. The encoded protein is involved in myelopoiesis, and defects in this gene have been associated with several myeloproliferative disorders. Two variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2011]

uniprot summary :

TET2: Catalyzes the conversion of methylcytosine (5mC) to 5- hydroxymethylcytosine (hmC). Plays an important role in myelopoiesis. The clear function of 5-hydroxymethylcytosine (hmC) is still unclear but it may influence chromatin structure and recruit specific factors or may constitute an intermediate component in cytosine demethylation. TET2 is frequently mutated in myeloproliferative disorders (MPD). These constitute a heterogeneous group of disorders, also known as myeloproliferative diseases or myeloproliferative neoplasms (MPN), characterized by cellular proliferation of one or more hematologic cell lines in the peripheral blood, distinct from acute leukemia. Included diseases are: essential thrombocythemia, polycythemia vera, primary myelofibrosis (chronic idiopathic myelofibrosis). Bone marrow samples from patients display uniformly low levels of hmC in genomic DNA compared to bone marrow samples from healthy controls as well as hypomethylation relative to controls at the majority of differentially methylated CpG sites. Defects in TET2 are a cause of polycythemia vera (PV). A myeloproliferative disorder characterized by abnormal proliferation of all hematopoietic bone marrow elements, erythroid hyperplasia, an absolute increase in total blood volume, but also by myeloid leukocytosis, thrombocytosis and splenomegaly. TET2 is frequently mutated in systemic mastocytosis; also known as systemic mast cell disease. A condition with features in common with myeloproliferative diseases. It is a clonal disorder of the mast cell and its precursor cells. The clinical symptoms and signs of systemic mastocytosis are due to accumulation of clonally derived mast cells in different tissues, including bone marrow, skin, the gastrointestinal tract, the liver, and the spleen. Defects in TET2 are a cause of myelodysplastic syndrome (MDS). A heterogeneous group of closely related clonal hematopoietic disorders. All are characterized by a hypercellular or hypocellular bone marrow with impaired morphology and maturation, dysplasia of the myeloid, megakaryocytic and/or erythroid lineages, and peripheral blood cytopenias resulting from ineffective blood cell production. Included diseases are: refractory anemia (RA), refractory anemia with ringed sideroblasts (RARS), refractory anemia with excess blasts (RAEB), refractory cytopenia with multilineage dysplasia and ringed sideroblasts (RCMD-RS). Chronic myelomonocytic leukemia (CMML) is a myelodysplastic/myeloproliferative disease. Myelodysplastic syndromes are considered a premalignant condition in a subgroup of patients that often progresses to acute myeloid leukemia (AML). Bone marrow samples from patients display uniformly low levels of hmC in genomic DNA compared to bone marrow samples from healthy controls as well as hypomethylation relative to controls at the majority of differentially methylated CpG sites. Belongs to the TET family. 3 isoforms of the human protein are produced by alternative splicing. Protein type: Tumor suppressor; Oxidoreductase; EC 1.14.11.n2. Chromosomal Location of Human Ortholog: 4q24. Molecular Function: protein binding; DNA binding; zinc ion binding; ferrous iron binding. Biological Process: spleen development; protein amino acid O-linked glycosylation; myeloid progenitor cell differentiation; cytosine metabolic process; hemoglobin metabolic process; 5-methylcytosine catabolic process; gene expression; myeloid cell differentiation; positive regulation of transcription from RNA polymerase II promoter; kidney development; cell cycle; regulation of gene expression, epigenetic; post-embryonic development. Disease: Myelodysplastic Syndrome

size1 :

48-Strip-Wells

price1 :

470 USD

size2 :

96-Strip-Wells

price2 :

680

size3 :

5x96-Strip-Wells

price3 :

3100

size4 :

10x96-Strip-Wells

price4 :

6095