ELISA/assay

Human Paired immunoglobulin-like type 2 receptor alpha, PILRA ELISA Kit

MBS9317067

48-Strip-Wells

470 USD

ELISA Kit

Human Paired immunoglobulin-like type 2 receptor alpha, PILRA ELISA Kit

[paired immunoglobin-like type 2 receptor alpha]

[Human Paired immunoglobulin-like type 2 receptor alpha (PILRA) ELISA kit; FDF03; cell surface receptor FDF03; inhibitory receptor PILRalpha; paired immunoglobin-like receptor alpha; paired immunoglobulin-like receptor alpha; paired immunoglobulin-like type 2 receptor alpha; paired immunoglobin-like type 2 receptor alpha]

[paired immunoglobulin-like type 2 receptor alpha isoform 1; Paired immunoglobulin-like type 2 receptor alpha; paired immunoglobulin-like type 2 receptor alpha; cell surface receptor FDF03; inhibitory receptor PILR-alpha; paired immunoglobin-like type 2 receptor alpha; Cell surface receptor FDF03; Inhibitory receptor PILR-alpha]

[PILRA]

[PILRA; PILRA; FDF03]

PILRA_HUMAN

Human

No significant cross-reactivity or interference between this analyte and analogues is observed.

Store all reagents at 2-8 degree C

Samples: Body fluids, tissue homogenates, secretions or feces samples. Assay Type: Quantitative Sandwich. Detection Range: 3.12 ng/ml - 100 ng/ml. Sensitivity: 1.0 ng/ml.

Intra-assay Precision: Intra-assay CV (%) is less than 15%. Inter-assay Precision: Inter-assay CV (%) is less than 15%. [CV(%) = SD/mean ×100].

Background/Introduction: This Quantitative Sandwich ELISA kit is only for in vitro research use only, not for drug, household, therapeutic or diagnostic applications! This kit is intended to be used for determination the level of PILRA (hereafter termed "analyte") in undiluted original Human body fluids, tissue homogenates, secretions or feces samples. This kit is NOT suitable for assaying non-biological sources of substances.

30179909

NP_038467.2

NM_013439.2

Q9UKJ1

34,005 Da

Herpes Simplex Infection Pathway (377873); Herpes Simplex Infection Pathway (377865)

Cell signaling pathways rely on a dynamic interaction between activating and inhibiting processes. SHP-1-mediated dephosphorylation of protein tyrosine residues is central to the regulation of several cell signaling pathways. Two types of inhibitory receptor superfamily members are immunoreceptor tyrosine-based inhibitory motif (ITIM)-bearing receptors and their non-ITIM-bearing, activating counterparts. Control of cell signaling via SHP-1 is thought to occur through a balance between PILRalpha-mediated inhibition and PILRbeta-mediated activation. These paired immunoglobulin-like receptor genes are located in a tandem head-to-tail orientation on chromosome 7. This particular gene encodes the ITIM-bearing member of the receptor pair, which functions in the inhibitory role. Alternative splicing has been observed at this locus and three variants, each encoding a distinct isoform, are described. [provided by RefSeq, Jul 2008]

PILRA: Paired receptors consist of highly related activating and inhibitory receptors and are widely involved in the regulation of the immune system. PILRA is thought to act as a cellular signaling inhibitory receptor by recruiting cytoplasmic phosphatases like PTPN6/SHP-1 and PTPN11/SHP-2 via their SH2 domains that block signal transduction through dephosphorylation of signaling molecules. Receptor for PIANP. 4 isoforms of the human protein are produced by alternative splicing. Protein type: Membrane protein, integral; Receptor, misc. Chromosomal Location of Human Ortholog: 7q22.1. Cellular Component: plasma membrane; integral to membrane. Molecular Function: protein binding. Biological Process: viral reproduction; signal transduction

48-Strip-Wells

470 USD

96-Strip-Wells

680

5x96-Strip-Wells

3100

10x96-Strip-Wells

6095