catalog number :
MBS9316833
products type :
ELISA Kit
products full name :
Human 3-phosphoinositide-dependent protein kinase 1, PDPK1 ELISA Kit
products short name :
3-phosphoinositide dependent protein kinase-1
products name syn :
Human 3-phosphoinositide-dependent protein kinase 1 (PDPK1) ELISA kit; MGC20087; MGC35290; PDK1; PRO0461; PkB kinase like gene 1; PkB-like 1; protein kinase; 3-phosphoinositide dependent protein kinase-1
other names :
3-phosphoinositide-dependent protein kinase 1 isoform 3; 3-phosphoinositide-dependent protein kinase 1; 3-phosphoinositide-dependent protein kinase 1; PkB kinase like gene 1; 3-phosphoinositide dependent protein kinase-1; 3-phosphoinositide dependent protein kinase 1
products gene name :
PDPK1
other gene names :
PDPK1; PDPK1; PDK1; PDPK2; PRO0461; PDK1; hPDK1
uniprot entry name :
PDPK1_HUMAN
storage stability :
Store all reagents at 2-8 degree C
ncbi acc num :
NP_001248745.1
ncbi gb acc num :
NM_001261816.1
ncbi mol weight :
63,152 Da
ncbi pathways :
Activation Of NMDA Receptor Upon Glutamate Binding And Postsynaptic Events Pathway (161033); Activation Of PKB Pathway (106436); Adaptive Immune System Pathway (366160); Aldosterone-regulated Sodium Reabsorption Pathway (130626); Aldosterone-regulated Sodium Reabsorption Pathway (130590); B Cell Receptor Signaling Pathway (198909); BCR Signaling Pathway (138058); CD28 Co-stimulation Pathway (119553); CD28 Dependent PI3K/Akt Signaling Pathway (119554); CREB Phosphorylation Through The Activation Of Ras Pathway (161036)
uniprot summary :
PDK1: an AGC kinase of the PKB family that contains a PH domain. Involved in a wide variety of processes including cell proliferation, differentiation and apoptosis. Autophosphorylation in the activation loop is necessary for activity. Phosphorylates and activates kinases including Akt, PKC isozymes, p70 S6K and RSK. Three alternatively-spliced isoforms have been described. Protein type: Protein kinase, Ser/Thr (non-receptor); Kinase, protein; EC 2.7.11.1; Nuclear receptor co-regulator; Protein kinase, AGC; AGC group; PKB family. Chromosomal Location of Human Ortholog: 16p13.3. Cellular Component: nucleoplasm; cell projection; focal adhesion; membrane; cytoplasm; cytoplasmic membrane-bound vesicle; plasma membrane; cytosol. Molecular Function: protein serine/threonine kinase activity; protein binding; phospholipase binding; 3-phosphoinositide-dependent protein kinase activity; kinase activity; protein kinase binding; insulin receptor binding; ATP binding; phospholipase activator activity. Biological Process: focal adhesion formation; regulation of mast cell degranulation; nerve growth factor receptor signaling pathway; protein amino acid autophosphorylation; T cell receptor signaling pathway; protein amino acid phosphorylation; synaptic transmission; regulation of transcription, DNA-dependent; regulation of I-kappaB kinase/NF-kappaB cascade; epidermal growth factor receptor signaling pathway; platelet activation; cell migration; fibroblast growth factor receptor signaling pathway; phosphoinositide-mediated signaling; transcription, DNA-dependent; activation of protein kinase B; calcium-mediated signaling; peptidyl-threonine phosphorylation; hyperosmotic response; cellular response to insulin stimulus; T cell costimulation; insulin receptor signaling pathway; negative regulation of toll-like receptor signaling pathway; negative regulation of protein kinase activity; innate immune response; positive regulation of release of sequestered calcium ion into cytosol; vascular endothelial growth factor receptor signaling pathway; actin cytoskeleton organization and biogenesis; blood coagulation; negative regulation of transforming growth factor beta receptor signaling pathway