ELISA/assay

Human 5-hydroxytryptamine receptor 2B, HTR2B ELISA Kit

MBS9316816

48-Strip-Wells

435 USD

ELISA Kit

Human 5-hydroxytryptamine receptor 2B, HTR2B ELISA Kit

5-hydroxytryptamine (serotonin) receptor 2B

Human 5-hydroxytryptamine receptor 2B (HTR2B) ELISA kit; 5-HT (2B); 5-HT2B; 5-HT 2B receptor; 5-hydroxytryptamine 2B receptor; 5-hydroxytryptamine (serotonin) receptor 2B

5-hydroxytryptamine receptor 2B; 5-hydroxytryptamine receptor 2B; 5-hydroxytryptamine receptor 2B; 5-HT-2B; 5-HT 2B receptor; serotonin receptor 2B; 5-hydroxytryptamine 2B receptor; 5-hydroxytryptamine receptor 2B variant b; 5-hydroxytryptamine (serotonin) receptor 2B, G protein-coupled; Serotonin receptor 2B

HTR2B

HTR2B; HTR2B; 5-HT2B; 5-HT(2B); 5-HT-2B; 5-HT2B

5HT2B_HUMAN

Human

No significant cross-reactivity or interference between this analyte and analogues is observed.

Store all reagents at 2-8 degree C

Assay Type: Quantitative Sandwich. Detection Range: 6.25 ng/ml - 200 ng/ml. Sensitivity: 1.0 ng/ml.

Intra-assay Precision: Intra-assay CV (%) is less than 15%. Inter-assay Precision: Inter-assay CV (%) is less than 15%. [CV(%) = SD/mean ×100].

Background/Introduction: This Quantitative Sandwich ELISA kit is only for in vitro research use only, not for drug, household, therapeutic or diagnostic applications! This kit is intended to be used for determination the level of HTR2B (hereafter termed "analyte") in undiluted original Human body fluids, tissue homogenates, secretions or feces samples. This kit is NOT suitable for assaying non-biological sources of substances.

222080049

NP_000858.3

NM_000867.4

P41595

54,298 Da

Amine Ligand-binding Receptors Pathway (106363); Calcium Signaling Pathway (83050); Calcium Signaling Pathway (459); Class A/1 (Rhodopsin-like Receptors) Pathway (106357); G Alpha (q) Signalling Events Pathway (106043); GPCR Downstream Signaling Pathway (119548); GPCR Ligand Binding Pathway (161020); GPCRs, Class A Rhodopsin-like Pathway (198886); Gap Junction Pathway (83072); Gap Junction Pathway (483)

This gene encodes one of the several different receptors for 5-hydroxytryptamine (serotonin) that belongs to the G-protein coupled receptor 1 family. Serotonin is a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. Serotonin receptors mediate many of the central and peripheral physiologic functions of serotonin, including regulation of cardiovascular functions and impulsive behavior. Population and family-based analyses of a minor allele (glutamine-to-stop substitution, designated Q20*) which blocks expression of this protein, and knockout studies in mice, suggest a role for this gene in impulsivity. However, other factors, such as elevated testosterone levels, may also be involved. [provided by RefSeq, Oct 2011]

5-HT(2B): This is one of the several different receptors for 5- hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. This receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. Plays a role in the regulation of impulsive behavior. Belongs to the G-protein coupled receptor 1 family. Protein type: Membrane protein, integral; Receptor, GPCR; GPCR, family 1; Membrane protein, multi-pass. Chromosomal Location of Human Ortholog: 2q36.3-q37.1. Cellular Component: neuron projection; integral to plasma membrane; cytoplasm; plasma membrane; synapse; cell junction. Molecular Function: serotonin binding; serotonin receptor activity; G-protein alpha-subunit binding; drug binding. Biological Process: heart morphogenesis; negative regulation of autophagy; cGMP biosynthetic process; phosphoinositide 3-kinase cascade; intestine smooth muscle contraction; behavior; positive regulation of MAP kinase activity; positive regulation of cell proliferation; protein kinase C activation; neural crest cell differentiation; embryonic morphogenesis; neural crest cell migration; serotonin receptor signaling pathway; regulation of behavior; response to drug; positive regulation of cytokine production; vasoconstriction; positive regulation of I-kappaB kinase/NF-kappaB cascade; positive regulation of nitric-oxide synthase activity; calcium-mediated signaling; positive regulation of phosphatidylinositol biosynthetic process; cellular calcium ion homeostasis; G-protein coupled receptor protein signaling pathway; G-protein coupled receptor internalization; phospholipase C activation; release of sequestered calcium ion into cytosol; positive regulation of cell division; positive regulation of endothelial cell proliferation; phosphorylation; negative regulation of apoptosis; positive regulation of cytokine secretion

48-Strip-Wells

435 USD

96-Strip-Wells

600