Human Alanyl-tRNA synthetase, cytoplasmic, AARS ELISA Kit | MyBioSource MBS9316528 product information

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product summary

company name :

MyBioSource

product type :

ELISA/assay

product name :

Human Alanyl-tRNA synthetase, cytoplasmic, AARS ELISA Kit

catalog :

MBS9316528

quantity :

48-Strip-Wells

price :

470 USD

product information

catalog number :

MBS9316528

products type :

ELISA Kit

products full name :

Human Alanyl-tRNA synthetase, cytoplasmic, AARS ELISA Kit

products short name :

[alanyl-tRNA synthetase]

products name syn :

[Human Alanyl-tRNA synthetase; cytoplasmic (AARS) ELISA kit; alanine tRNA ligase 1cytoplasmic; alanyl-tRNA synthetase]

other names :

[alanine--tRNA ligase, cytoplasmic; Alanine--tRNA ligase, cytoplasmic; alanine--tRNA ligase, cytoplasmic; alaRS; renal carcinoma antigen NY-REN-42; alanine tRNA ligase 1, cytoplasmic; alanyl-tRNA synthetase, cytoplasmic; alanyl-tRNA synthetase; Alanyl-tRNA synthetase; AlaRS; Renal carcinoma antigen NY-REN-42]

products gene name :

[AARS]

other gene names :

[AARS; AARS; CMT2N; AlaRS]

uniprot entry name :

SYAC_HUMAN

reactivity :

Human

specificity :

No significant cross-reactivity or interference between this analyte and analogues is observed.

storage stability :

Store all reagents at 2-8 degree C

other info1 :

Assay Type: Quantitative Sandwich. Detection Range: 0.625 ng/ml - 20 ng/ml. Sensitivity: 0.1 ng/ml.

other info2 :

Intra-assay Precision: Intra-assay CV (%) is less than 15%. Inter-assay Precision: Inter-assay CV (%) is less than 15%. [CV(%) = SD/mean ×100].

products description :

Background/Introduction: This Quantitative Sandwich ELISA kit is only for in vitro research use only, not for drug, household, therapeutic or diagnostic applications! This kit is intended to be used for determination the level of AARS (hereafter termed "analyte") in undiluted original Human body fluids, tissue homogenates, secretions or feces samples. This kit is NOT suitable for assaying non-biological sources of substances.

ncbi gi num :

109148542

ncbi acc num :

NP_001596.2

ncbi gb acc num :

NM_001605.2

uniprot acc num :

P49588

ncbi mol weight :

106,810 Da

ncbi pathways :

Aminoacyl-tRNA Biosynthesis Pathway (83030); Aminoacyl-tRNA Biosynthesis Pathway (424); Aminoacyl-tRNA Biosynthesis, Eukaryotes Pathway (413439); Aminoacyl-tRNA Biosynthesis, Eukaryotes Pathway (468360); Cytosolic TRNA Aminoacylation Pathway (105981); Gene Expression Pathway (105937); TRNA Aminoacylation Pathway (105980)

ncbi summary :

The human alanyl-tRNA synthetase (AARS) belongs to a family of tRNA synthases, of the class II enzymes. Class II tRNA synthases evolved early in evolution and are highly conserved. This is reflected by the fact that 498 of the 968-residue polypeptide human AARS shares 41% identity witht the E.coli protein. tRNA synthases are the enzymes that interpret the RNA code and attach specific aminoacids to the tRNAs that contain the cognate trinucleotide anticodons. They consist of a catalytic domain which interacts with the amino acid acceptor-T psi C helix of the tRNA, and a second domain which interacts with the rest of the tRNA structure. [provided by RefSeq, Jul 2008]

uniprot summary :

AARS: Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction: alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged tRNA(Ala) via its editing domain. Defects in AARS are the cause of Charcot-Marie-Tooth disease type 2N (CMT2N). It is an axonal form of Charcot-Marie-Tooth disease, a disorder of the peripheral nervous system, characterized by progressive weakness and atrophy, initially of the peroneal muscles and later of the distal muscles of the arms. Charcot-Marie-Tooth disease is classified in two main groups on the basis of electrophysiologic properties and histopathology: primary peripheral demyelinating neuropathies(designated CMT1 when they are dominantly inherited) and primary peripheral axonal neuropathies (CMT2). Neuropathies of the CMT2 group are characterized by signs of axonal regeneration in the absence of obvious myelin alterations, normal or slightly reduced nerve conduction velocities, and progressive distal muscle weakness and atrophy. Nerve conduction velocities are normal or slightly reduced. Belongs to the class-II aminoacyl-tRNA synthetase family. Protein type: EC 6.1.1.7; RNA-binding; Translation; Ligase. Chromosomal Location of Human Ortholog: 16q22. Cellular Component: membrane; cytoplasm; cytosol. Molecular Function: amino acid binding; zinc ion binding; alanine-tRNA ligase activity; ATP binding; tRNA binding. Biological Process: tRNA aminoacylation for protein translation; protein folding; hair follicle development; tRNA processing; unfolded protein response; regulation of translational fidelity; cerebellar Purkinje cell layer development; gene expression; negative regulation of neuron apoptosis; tRNA modification; neuromuscular process controlling balance; response to amino acid stimulus; alanyl-tRNA aminoacylation. Disease: Epileptic Encephalopathy, Early Infantile, 29; Charcot-marie-tooth Disease, Axonal, Type 2n

size1 :

48-Strip-Wells

price1 :

470 USD

size2 :

96-Strip-Wells

price2 :

680

size3 :

5x96-Strip-Wells

price3 :

3100

size4 :

10x96-Strip-Wells

price4 :

6095