catalog number :
MBS9316329
products type :
ELISA Kit
products full name :
Human Double C2-like domain-containing protein beta, DOC2B ELISA Kit
products short name :
[double C2-like domains, beta]
products name syn :
[Human Double C2-like domain-containing protein beta (DOC2B) ELISA kit; DOC2BL; double C2-like domains; beta-like; double C2-like domains; beta]
other names :
[double C2-like domain-containing protein beta; Double C2-like domain-containing protein beta; double C2-like domain-containing protein beta; doc2-beta; double C2-like domains, beta]
products gene name :
[DOC2B]
other gene names :
[DOC2B; DOC2B; DOC2BL; DOC2BL; Doc2-beta]
uniprot entry name :
DOC2B_HUMAN
specificity :
No significant cross-reactivity or interference between this analyte and analogues is observed.
storage stability :
Store all reagents at 2-8 degree C
other info1 :
Samples: Undiluted original Human body fluids, tissue homogenates, secretions or feces samples. This kit is NOT suitable for assaying non-biological sources of substances. Assay Type: Sandwich. Detection Range: 3.12 ng/ml - 100 ng/ml. Sensitivity: 1.0 ng/ml.
other info2 :
Intra-assay Precision: Intra-assay CV (%) is less than 15%. Inter-assay Precision: Inter-assay CV (%) is less than 15%. [CV(%) = SD/mean ×100].
products description :
Background/Introduction: This Quantitative Sandwich ELISA kit is only for in vitro research use only, NOT for drug, household, therapeutic or diagnostic applications! This kit is intended to be used for determination the level of DOC2B (hereafter termed "analyte") in undiluted original Human body fluids, tissue homogenates, secretions or feces samples. This kit is NOT suitable for assaying non-biological sources of substances.
ncbi acc num :
NP_003576.2
ncbi gb acc num :
NM_003585.4
ncbi mol weight :
45,949 Da
ncbi summary :
There are at least two protein isoforms of the Double C2 protein, namely alpha (DOC2A) and beta (DOC2B), which contain two C2-like domains. DOC2A and DOC2B are encoded by different genes; these genes are at times confused with the unrelated DAB2 gene which was initially named DOC-2. DOC2B is expressed ubiquitously and is suggested to be involved in Ca(2+)-dependent intracellular vesicle trafficking in various types of cells. [provided by RefSeq, Jul 2008]
uniprot summary :
DOC2B: Calcium sensor which positively regulates SNARE- dependent fusion of vesicles with membranes. Binds phospholipids in a calcium-dependent manner and may act at the priming stage of fusion by modifying membrane curvature to stimulate fusion. Involved in calcium-triggered exocytosis in chromaffin cells and calcium-dependent spontaneous release of neurotransmitter in absence of action potentials in neuronal cells. Involved both in glucose-stimulated insulin secretion in pancreatic cells and insulin-dependent GLUT4 transport to the plasma membrane in adipocytes. Protein type: Lipid-binding. Chromosomal Location of Human Ortholog: 17p13.3. Cellular Component: SNARE complex; synaptic vesicle; cytoplasm; plasma membrane. Molecular Function: calcium-dependent phospholipid binding; transporter activity. Biological Process: positive regulation of calcium ion-dependent exocytosis; protein localization; calcium ion-dependent exocytosis of neurotransmitter; positive regulation of insulin secretion; positive regulation of vesicle fusion
size4 :
10x96-Strip-Wells