ELISA/assay

Human Dentin matrix protein 4, FAM20C ELISA Kit

MBS9316277

48-Strip-Wells

470 USD

ELISA Kit

Human Dentin matrix protein 4, FAM20C ELISA Kit

[family with sequence similarity 20, member C]

[Human Dentin matrix protein 4 (FAM20C) ELISA kit; DKFZp547C074; DMP4; RNS; dentin matrix protein 4; family with sequence similarity 20; member C]

[extracellular serine/threonine protein kinase FAM20C; Extracellular serine/threonine protein kinase FAM20C; extracellular serine/threonine protein kinase FAM20C; dentin matrix protein 4; golgi-enriched fraction casein kinase; family with sequence similarity 20, member C; Dentin matrix protein 4; DMP-4; Golgi-enriched fraction casein kinase; GEF-CK; Protein FAM20C]

[FAM20C]

[FAM20C; FAM20C; RNS; DMP4; DMP-4; GEF-CK; DMP4; DMP-4; GEF-CK]

DMP4_HUMAN

Human

No significant cross-reactivity or interference between this analyte and analogues is observed.

Store all reagents at 2-8 degree C

Samples: Body fluids, tissue homogenates, secretions or feces samples. Assay Type: Quantitative Sandwich. Detection Range: 0.25 ng/ml - 8 ng/ml. Sensitivity: 0.1 ng/ml.

Intra-assay Precision: Intra-assay CV (%) is less than 15%. Inter-assay Precision: Inter-assay CV (%) is less than 15%. [CV(%) = SD/mean ×100].

Background/Introduction: This Quantitative Sandwich ELISA kit is only for in vitro research use only, not for drug, household, therapeutic or diagnostic applications! This kit is intended to be used for determination the level of FAM20C (hereafter termed "analyte") in undiluted original Human body fluids, tissue homogenates, secretions or feces samples. This kit is NOT suitable for assaying non-biological sources of substances.

116174742

NP_064608.2

NM_020223.3

Q8IXL6

66,234 Da

This gene encodes a member of the family of secreted protein kinases. The encoded protein binds calcium and phosphorylates proteins involved in bone mineralization. Mutations in this gene are associated with the autosomal recessive disorder Raine syndrome. [provided by RefSeq, Apr 2014]

FAM20C: an atypical serine protein kinase that localizes within the Golgi apparatus and is secreted. Distantly related to the Drosophila Golgi-localized kinase Four-jointed. Phosphorylates secretory proteins including the caseins and members of the small integrin-binding ligand, N-linked glycoprotein (SIBLING) protein family, which modulate biomineralization. Colocalizes with the Golgi resident protein GM130. Preferentially phosphorylates its targets within the S-x-E/pS motif. Requires Mn2+ as an alternative to Mg2+ as the activating cation. Defects in FAM20C are the cause of Raine syndrome (RNS). RNS is an autosomal recessive osteosclerotic bone dysplasia with neonatal lethal outcome. Clinical features include generalized osteosclerosis, craniofacial dysplasia and microcephaly. Two isoforms of the human protein are produced by alternative splicing. Protein type: Protein kinase, Ser/Thr (non-receptor); Secreted, signal peptide; EC 2.7.11.1; Secreted. Chromosomal Location of Human Ortholog: 7p22.3. Cellular Component: Golgi apparatus; extracellular space. Molecular Function: protein serine/threonine kinase activity; calcium ion binding. Biological Process: positive regulation of osteoblast differentiation; regulation of fibroblast growth factor receptor signaling pathway; positive regulation of bone mineralization; regulation of phosphorus metabolic process; protein amino acid phosphorylation. Disease: Raine Syndrome

48-Strip-Wells

470 USD

96-Strip-Wells

680

5x96-Strip-Wells

3100

10x96-Strip-Wells

6095