Human Spastin (SPAST) ELISA Kit | MyBioSource MBS9313352 product information

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product summary

company name :

MyBioSource

product type :

ELISA/assay

product name :

Human Spastin (SPAST) ELISA Kit

catalog :

MBS9313352

quantity :

48-Strip-Wells

price :

470 USD

product information

catalog number :

MBS9313352

products type :

ELISA Kit

products full name :

Human Spastin (SPAST) ELISA Kit

products short name :

[Spastin (SPAST)]

other names :

[spastin isoform 2; Spastin; spastin; spastic paraplegia 4 protein; spastic paraplegia 4 (autosomal dominant; spastin); spastin; Spastic paraplegia 4 protein]

products gene name :

[SPAST]

other gene names :

[SPAST; SPAST; FSP2; SPG4; ADPSP; ADPSP; FSP2; KIAA1083; SPG4]

uniprot entry name :

SPAST_HUMAN

reactivity :

Human

specificity :

No significant cross-reactivity or interference between this analyte and analogues is observed.

storage stability :

Store all reagents at 2-8 degree C

other info1 :

Samples: Undiluted original Human body fluids, tissue homogenates, secretions or feces samples. Assay Type: Sandwich (Quantitative). Detection Range: 0.625 ng/ml - 20 ng/ml. Sensitivity: 0.1 ng/ml.

other info2 :

Intra-assay Precision: Intra-assay CV (%) is less than 15%. Inter-assay Precision: Inter-assay CV (%) is less than 15%. [CV(%) = SD/mean ×100].

products description :

Background: This Quantitative Sandwich ELISA kit is only for in vitro research use only, not for drug, household, therapeutic or diagnostic applications! This kit is intended to be used for determination the level of SPAST (hereafter termed "analyte") in undiluted original Human body fluids, tissue homogenates, secretions or feces samples. This kit is NOT suitable for assaying non-biological sources of substances.

ncbi gi num :

40806170

ncbi acc num :

NP_955468.1

ncbi gb acc num :

NM_199436.1

uniprot acc num :

Q9UBP0

ncbi mol weight :

67,197 Da

ncbi summary :

This gene encodes a member of the AAA (ATPases associated with a variety of cellular activities) protein family. Members of this protein family share an ATPase domain and have roles in diverse cellular processes including membrane trafficking, intracellular motility, organelle biogenesis, protein folding, and proteolysis. The encoded ATPase may be involved in the assembly or function of nuclear protein complexes. Two transcript variants encoding distinct isoforms have been identified for this gene. Other alternative splice variants have been described but their full length sequences have not been determined. Mutations associated with this gene cause the most frequent form of autosomal dominant spastic paraplegia 4. [provided by RefSeq, Jul 2008]

uniprot summary :

spastin: ATP-dependent microtubule severing protein. Microtubule severing may promote reorganization of cellular microtubule arrays and the release of microtubules from the centrosome following nucleation. Required for membrane traffic from the endoplasmic reticulum (ER) to the Golgi and for completion of the abscission stage of cytokinesis. May also play a role in axon growth and the formation of axonal branches. Defects in SPAST are the cause of spastic paraplegia autosomal dominant type 4 (SPG4). Spastic paraplegia is a neurodegenerative disorder characterized by a slow, gradual, progressive weakness and spasticity of the lower limbs. Rate of progression and the severity of symptoms are quite variable. Initial symptoms may include difficulty with balance, weakness and stiffness in the legs, muscle spasms, and dragging the toes when walking. In some forms of the disorder, bladder symptoms (such as incontinence) may appear, or the weakness and stiffness may spread to other parts of the body. SPG4 is the most common form of autosomal dominant spastic paraplegias. Belongs to the AAA ATPase family. Spastin subfamily. 4 isoforms of the human protein are produced by alternative promoter. Protein type: Membrane protein, integral; EC 3.6.4.3; Cytoskeletal. Chromosomal Location of Human Ortholog: 2p24-p21. Cellular Component: microtubule cytoskeleton; centrosome; microtubule; endoplasmic reticulum; perinuclear region of cytoplasm; cytoplasm; integral to membrane; spindle; cytoplasmic vesicle; midbody; nucleus; endosome. Molecular Function: protein binding; microtubule binding; beta-tubulin binding; microtubule-severing ATPase activity; alpha-tubulin binding; ATP binding. Biological Process: positive regulation of microtubule depolymerization; ER to Golgi vesicle-mediated transport; axonogenesis; metabolic process; microtubule severing; microtubule bundle formation; protein homooligomerization; cytoplasmic microtubule organization and biogenesis. Disease: Spastic Paraplegia 4, Autosomal Dominant

size1 :

48-Strip-Wells

price1 :

470 USD

size2 :

96-Strip-Wells

price2 :

680

size3 :

5x96-Strip-Wells

price3 :

3100

size4 :

10x96-Strip-Wells

price4 :

6095