catalog number :
MBS9313258
products type :
ELISA Kit
products full name :
Mouse Adenylate Cyclase 8, Brain (ADCY8) ELISA Kit
products short name :
Adenylate Cyclase 8, Brain (ADCY8)
other names :
adenylate cyclase type 8; Adenylate cyclase type 8; adenylate cyclase type 8; adenylyl cyclase 8; ATP pyrophosphate-lyase 8; adenylyl cyclase-8, brain; adenylate cyclase type VIII; ca(2+)/calmodulin-activated adenylyl cyclase; adenylate cyclase 8 (brain); ATP pyrophosphate-lyase 8; Adenylate cyclase type VIII; Adenylyl cyclase 8; AC8; Ca(2+)/calmodulin-activated adenylyl cyclase
products gene name :
ADCY8
other gene names :
ADCY8; ADCY8; AC8; ADCY3; HBAC1; AC8
uniprot entry name :
ADCY8_HUMAN
storage stability :
Store all reagents at 2-8 degree C
ncbi acc num :
NP_001106.1
ncbi gb acc num :
NM_001115.2
ncbi mol weight :
140,122 Da
ncbi pathways :
Activation Of GABAB Receptors Pathway (187181); Activation Of NMDA Receptor Upon Glutamate Binding And Postsynaptic Events Pathway (161033); Adenylate Cyclase Activating Pathway (106499); Adenylate Cyclase Inhibitory Pathway (106500); Aquaporin-mediated Transport Pathway (187187); Bile Secretion Pathway (193146); Bile Secretion Pathway (193095); CREB Phosphorylation Through The Activation Of Adenylate Cyclase Pathway (161039); Ca-dependent Events Pathway (106497); CaM Pathway (106468)
ncbi summary :
Adenylate cyclase is a membrane bound enzyme that catalyses the formation of cyclic AMP from ATP. The enzymatic activity is under the control of several hormones, and different polypeptides participate in the transduction of the signal from the receptor to the catalytic moiety. Stimulatory or inhibitory receptors (Rs and Ri) interact with G proteins (Gs and Gi) that exhibit GTPase activity and they modulate the activity of the catalytic subunit of the adenylyl cyclase [provided by RefSeq, Jul 2008]
uniprot summary :
ADCY8: This is a membrane-bound, calcium-stimulable adenylyl cyclase. May be involved in learning, in memory and in drug dependence. Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. Protein type: Transporter; Membrane protein, integral; Membrane protein, multi-pass; Nucleotide Metabolism - purine; EC 4.6.1.1; Lyase; Transporter, aquaporin family; Adenylyl cyclase. Chromosomal Location of Human Ortholog: 8q24. Cellular Component: membrane; plasma membrane; integral to membrane. Molecular Function: metal ion binding; calcium- and calmodulin-responsive adenylate cyclase activity; ATP binding; adenylate cyclase activity. Biological Process: epidermal growth factor receptor signaling pathway; fibroblast growth factor receptor signaling pathway; nerve growth factor receptor signaling pathway; water transport; activation of protein kinase A; signal transduction; G-protein signaling, adenylate cyclase activating pathway; synaptic transmission; learning and/or memory; long-term memory; phospholipase C activation; energy reserve metabolic process; renal water homeostasis; innate immune response; cAMP biosynthetic process; G-protein signaling, adenylate cyclase inhibiting pathway; transmembrane transport