ELISA/assay

Human Synaptotagmin I (SYT1) ELISA Kit

MBS9312725

48-Strip-Wells

470 USD

ELISA Kit

Human Synaptotagmin I (SYT1) ELISA Kit

[Synaptotagmin I (SYT1)]

[SYT1 protein; Synaptotagmin-1; synaptotagmin-1; sytI; synaptotagmin 1; synaptotagmin I; Synaptotagmin I; SytI; p65]

[SYT1]

[SYT1; SYT1; P65; SYT; SVP65; SVP65; SYT; SytI]

SYT1_HUMAN

Human

No significant cross-reactivity or interference between this analyte and analogues is observed.

Store all reagents at 2-8 degree C

Samples: Human Body Fluids And Tissue Homogenates. Assay Type: Quantitative Sandwich. Detection Range: 3.12ng/ml-100ng/ml. Sensitivity: 1.0ng/ml.

Intra-assay Precision: Intra-assay CV (%) is less than 15%. Inter-assay Precision: Inter-assay CV (%) is less than 15%. [CV(%) = SD/mean ×100]. All CV% should be compared by concentration, not compared by OD values.

Background/Introduction: This Quantitative Sandwich ELISA kit is for lab reagent/research use only, not for drug, household, therapeutic or diagnostic applications! This kit is intended to be used for determine the level of SYPL1 (hereafter termed "analyte") in undiluted original Human body fluids and tissue homogenates. This kit is NOT suitable for assaying non-biological sources of substances.

37589130

AAH58917.1

P21579

47,573 Da

Acetylcholine Neurotransmitter Release Cycle Pathway (106525); Botulinum Neurotoxicity Pathway (105734); Disease Pathway (530764); Dopamine Neurotransmitter Release Cycle Pathway (106523); Effects Of Botulinum Toxin Pathway (138028); GABA Synthesis, Release, Reuptake And Degradation Pathway (187174); Glutamate Neurotransmitter Release Cycle Pathway (106522); Neuronal System Pathway (106513); Neurotransmitter Release Cycle Pathway (106518); Norepinephrine Neurotransmitter Release Cycle Pathway (106519)

The synaptotagmins are integral membrane proteins of synaptic vesicles thought to serve as Ca(2+) sensors in the process of vesicular trafficking and exocytosis. Calcium binding to synaptotagmin-1 participates in triggering neurotransmitter release at the synapse (Fernandez-Chacon et al., 2001 [PubMed 11242035]).[supplied by OMIM, Jul 2010]

SYT1: an integral membrane protein of synaptic vesicles thought to serve as a Ca(2+) sensor in the process of vesicular trafficking and exocytosis. Calcium binding to synaptotagmin I participates in triggering neurotransmitter release at the synapse. Binds acidic phospholipids with a specificity that requires the presence of both an acidic head group and a diacyl backbone. A Ca(2+)-dependent interaction between synaptotagmin and putative receptors for activated protein kinase C has also been reported. It can bind to at least three additional proteins in a Ca(2+)-independent manner; these are neurexins, syntaxin and AP2. Protein type: Calcium-binding; Membrane protein, integral; Vesicle. Chromosomal Location of Human Ortholog: 12cen-q21. Cellular Component: SNARE complex; presynaptic membrane; synaptic vesicle; neuron projection; synaptic vesicle membrane; integral to membrane; plasma membrane; excitatory synapse; cell junction. Molecular Function: protein C-terminus binding; identical protein binding; clathrin binding; calcium-dependent phospholipid binding; transporter activity; calcium ion binding; calcium-dependent protein binding; calmodulin binding; protein binding; SNARE binding; phosphatidylinositol-4,5-bisphosphate binding; low-density lipoprotein receptor binding; phosphatidylserine binding; syntaxin-1 binding; phosphatidylinositol binding. Biological Process: regulation of synaptic transmission, glutamatergic; neurotransmitter secretion; positive regulation of vesicle fusion; pathogenesis; positive regulation of synaptic transmission; regulation of exocytosis; positive regulation of calcium ion-dependent exocytosis; synaptic transmission; synaptic vesicle exocytosis; vesicle docking; glutamate secretion; detection of calcium ion; protein homooligomerization

48-Strip-Wells

470 USD

96-Strip-Wells

680

5x96-Strip-Wells

3100

10x96-Strip-Wells

6095