ELISA/assay

Human Telethonin (TELE) ELISA Kit

MBS9312406

48-Strip-Wells

470 USD

ELISA Kit

Human Telethonin (TELE) ELISA Kit

[Telethonin (TELE)]

[telethonin; Telethonin; telethonin; titin cap protein; 19 kDa sarcomeric protein; limb girdle muscular dystrophy 2G (autosomal recessive); titin-cap; Titin cap protein]

[TELE]

[TCAP; TCAP; TELE; CMD1N; T-cap; LGMD2G; telethonin]

TELT_HUMAN

Human

No significant cross-reactivity or interference between this analyte and analogues is observed.

Store all reagents at 2-8 degree C

Samples: Body fluids, tissue homogenates, secretions or feces samples. Assay Type: Quantitative Sandwich. Detection Range: 3.12 ng/ml - 100 ng/ml. Sensitivity: 1.0 ng/ml.

Intra-assay Precision: Intra-assay CV (%) is less than 15%. Inter-assay Precision: Inter-assay CV (%) is less than 15%. [CV(%) = SD/mean ×100].

Background/Introduction: This Quantitative Sandwich ELISA kit is only for in vitro research use only, not for drug, household, therapeutic or diagnostic applications! This kit is intended to be used for determination the level of TELE (hereafter termed "analyte") in undiluted original Human body fluids, tissue homogenates, secretions or feces samples. This kit is NOT suitable for assaying non-biological sources of substances.

4507435

NP_003664.1

NM_003673.3

O15273

19,052 Da

Muscle Contraction Pathway (106261); Striated Muscle Contraction Pathway (198903); Striated Muscle Contraction Pathway (106262)

Sarcomere assembly is regulated by the muscle protein titin. Titin is a giant elastic protein with kinase activity that extends half the length of a sarcomere. It serves as a scaffold to which myofibrils and other muscle related proteins are attached. This gene encodes a protein found in striated and cardiac muscle that binds to the titin Z1-Z2 domains and is a substrate of titin kinase, interactions thought to be critical to sarcomere assembly. Mutations in this gene are associated with limb-girdle muscular dystrophy type 2G. [provided by RefSeq, Jul 2008]

Telethonin: a muscle assembly regulating factor that interacts with the giant kinase titin. Sarcomere assembly is regulated by the muscle protein titin. Titin is a giant elastic protein with kinase activity that extends half the length of a sarcomere. It serves as a scaffold to which myofibrils and other muscle related proteins are attached. Telethonin is found in striated and cardiac muscle that binds to the titin Z1-Z2 domains and is a substrate of titin kinase, interactions thought to be critical to sarcomere assembly. Mutations in this gene are associated with limb-girdle muscular dystrophy type 2G. Protein type: Motility/polarity/chemotaxis. Chromosomal Location of Human Ortholog: 17q12. Cellular Component: I band; Z disc; cytosol. Molecular Function: protein binding, bridging; protein binding; structural constituent of muscle; titin binding; FATZ binding. Biological Process: cardiac muscle hypertrophy; adult heart development; skeletal muscle contraction; somitogenesis; muscle thin filament assembly; detection of mechanical stimulus; cardiac myofibril assembly; sarcomere organization; muscle filament sliding; muscle thick filament assembly; cardiac muscle fiber development; cardiac muscle morphogensis; sarcomerogenesis; protein complex assembly; otic vesicle formation; cardiac muscle contraction. Disease: Muscular Dystrophy, Limb-girdle, Type 2g; Cardiomyopathy, Dilated, 1n

48-Strip-Wells

470 USD

96-Strip-Wells

680

5x96-Strip-Wells

3100

10x96-Strip-Wells

6095