ELISA/assay

Human Neuroligin 3 (NLGN3) ELISA Kit

MBS9312211

48-Strip-Wells

470 USD

ELISA Kit

Human Neuroligin 3 (NLGN3) ELISA Kit

[Neuroligin 3 (NLGN3)]

[neuroligin-3 isoform 3; Neuroligin-3; neuroligin-3; gliotactin homolog; neuroligin 3; Gliotactin homolog]

[NLGN3]

[NLGN3; NLGN3; HNL3; KIAA1480; NL3]

NLGN3_HUMAN

Human

No significant cross-reactivity or interference between this analyte and analogues is observed.

Store all reagents at 2-8 degree C

Assay Type: Sandwich. Detection Range: 3.12 ng/ml - 100 ng/ml. Sensitivity: The sensitivity of this kit is 1.0 ng/ml.

Intra-assay Precision: Intra-assay CV (%) is less than 15%. Inter-assay Precision: Inter-assay CV (%) is less than 15%. [CV(%) = SD/mean ×100].

Background/Introduction: This Quantitative Sandwich ELISA kit is only for in vitro research use only, not for drug, household, therapeutic or diagnostic applications! This kit is intended to be used for determination the level of NLGN3 (hereafter termed this analyte) in undiluted original Human body fluids, tissue homogenates, secretions and feces samples.

262359974

NP_001160132.1

NM_001166660.1

Q9NZ94

93,895 Da

Cell Adhesion Molecules (CAMs) Pathway (83069); Cell Adhesion Molecules (CAMs) Pathway (480)

This gene encodes a member of a family of neuronal cell surface proteins. Members of this family may act as splice site-specific ligands for beta-neurexins and may be involved in the formation and remodeling of central nervous system synapses. Mutations in this gene may be associated with autism and Asperger syndrome. Multiple transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Oct 2009]

NLGN3: Cell surface protein involved in cell-cell-interactions via its interactions with neurexin family members. Plays a role in synapse function and synaptic signal transmission, and may mediate its effects by clustering other synaptic proteins. May promote the initial formation of synapses, but is not essential for this. May also play a role in glia-glia or glia-neuron interactions in the developing peripheral nervous system. Defects in NLGN3 may be the cause of susceptibility to autism X-linked type 1 (AUTSX1). AUTSX1 is a pervasive developmental disorder (PDD), prototypically characterized by impairments in reciprocal social interaction and communication, restricted and stereotyped patterns of interests and activities, and the presence of developmental abnormalities by 3 years of age. Defects in NLGN3 may be the cause of susceptibility to X- linked Asperger syndrome 1 (ASPGX1). ASPGX1 is considered to be a form of childhood autism. Belongs to the type-B carboxylesterase/lipase family. 2 isoforms of the human protein are produced by alternative splicing. Protein type: Motility/polarity/chemotaxis; Membrane protein, integral; Cell adhesion. Chromosomal Location of Human Ortholog: Xq13.1. Cellular Component: extracellular space; cell surface; endocytic vesicle; integral to plasma membrane; excitatory synapse; synapse; cell junction. Molecular Function: protein binding; neurexin binding; cell adhesion molecule binding; receptor activity. Biological Process: regulation of synaptic transmission; receptor-mediated endocytosis; rhythmic synaptic transmission; axon extension; metabolic process; neurological control of breathing; social behavior; learning; positive regulation of synaptic transmission, glutamatergic; positive regulation of synaptogenesis; regulation of inhibitory postsynaptic membrane potential; synaptogenesis; adult behavior; synapse organization and biogenesis; oligodendrocyte differentiation; visual learning; neuron adhesion. Disease: Asperger Syndrome, X-linked, Susceptibility To, 1; Autism, Susceptibility To, X-linked 1

48-Strip-Wells

470 USD

96-Strip-Wells

680

5x96-Strip-Wells

3100

10x96-Strip-Wells

6095