Human Importin 5 (IPO5) ELISA Kit | MyBioSource MBS9311906 product information

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product summary

company name :

MyBioSource

product type :

ELISA/assay

product name :

Human Importin 5 (IPO5) ELISA Kit

catalog :

MBS9311906

quantity :

48-Strip-Wells

price :

470 USD

product information

catalog number :

MBS9311906

products type :

ELISA Kit

products full name :

Human Importin 5 (IPO5) ELISA Kit

products short name :

[Importin 5 (IPO5)]

other names :

[importin-5; Importin-5; importin-5; karyopherin beta-3; RAN binding protein 5; ran-binding protein 5; importin beta-3 subunit; importin subunit beta-3; Ran_GTP binding protein 5; karyopherin (importin) beta 3; importin 5; Importin subunit beta-3; Karyopherin beta-3; Ran-binding protein 5]

products gene name :

[IPO5]

other gene names :

[IPO5; IPO5; IMB3; Pse1; imp5; KPNB3; RANBP5; KPNB3; RANBP5; Imp5; RanBP5]

uniprot entry name :

IPO5_HUMAN

reactivity :

Human

specificity :

No significant cross-reactivity or interference between this analyte and analogues is observed.

storage stability :

Store all reagents at 2-8 degree C

other info1 :

Samples: Human Serum, Plasma Or Tissue Homogenates Samples. Assay Type: Quantitative Sandwich. Detection Range: 0.5ng/ml-16ng/ml. Sensitivity: 0.1ng/ml.

other info2 :

Intra-assay Precision: Intra-assay CV (%) is less than 15%. Inter-assay Precision: Inter-assay CV (%) is less than 15%. [CV(%) = SD/mean ×100]. All CV% should be compared by concentration, not compared by OD values.

products description :

Background/Introduction: This Quantitative Sandwich ELISA kit is for lab reagent/research use only, not for drug, household, therapeutic or diagnostic applications! This kit is intended to be used for determine the level of IP6K1 (hereafter termed "analyte") in undiluted original Human serum, plasma or tissue homogenates samples. For other sample types please contact tech support to determine compatibility with this assay. This kit is not suitable for assaying non-biological sources of substances.

ncbi gi num :

24797086

ncbi acc num :

NP_002262.3

ncbi gb acc num :

NM_002271.4

uniprot acc num :

O00410

ncbi mol weight :

123,630 Da

ncbi pathways :

Disease Pathway (530764); Influenza Infection Pathway (106067); Influenza Life Cycle Pathway (106068); Influenza Viral RNA Transcription And Replication Pathway (106074); VRNP Assembly Pathway (106075)

ncbi summary :

Nucleocytoplasmic transport, a signal- and energy-dependent process, takes place through nuclear pore complexes embedded in the nuclear envelope. The import of proteins containing a nuclear localization signal (NLS) requires the NLS import receptor, a heterodimer of importin alpha and beta subunits also known as karyopherins. Importin alpha binds the NLS-containing cargo in the cytoplasm and importin beta docks the complex at the cytoplasmic side of the nuclear pore complex. In the presence of nucleoside triphosphates and the small GTP binding protein Ran, the complex moves into the nuclear pore complex and the importin subunits dissociate. Importin alpha enters the nucleoplasm with its passenger protein and importin beta remains at the pore. Interactions between importin beta and the FG repeats of nucleoporins are essential in translocation through the pore complex. The protein encoded by this gene is a member of the importin beta family. [provided by RefSeq, Jul 2008]

uniprot summary :

KPNB3: Functions in nuclear protein import as nuclear transport receptor. Serves as receptor for nuclear localization signals (NLS) in cargo substrates. Is thought to mediate docking of the importin/substrate complex to the nuclear pore complex (NPC) through binding to nucleoporin and the complex is subsequently translocated through the pore by an energy requiring, Ran- dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to the importin, the importin/substrate complex dissociates and importin is re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. Mediates the nuclear import of ribosomal proteins RPL23A, RPS7 and RPL5. Binds to a beta-like import receptor binding (BIB) domain of RPL23A. In vitro, mediates nuclear import of H2A, H2B, H3 and H4 histones. In case of HIV-1 infection, binds and mediates the nuclear import of HIV-1 Rev. Belongs to the importin beta family. 3 isoforms of the human protein are produced by alternative splicing. Protein type: Nuclear import; Karyopherin; Nucleolus. Chromosomal Location of Human Ortholog: 13q32.2. Cellular Component: nucleoplasm; Golgi apparatus; nuclear membrane; intracellular membrane-bound organelle; membrane; cytoplasm; nucleolus; nuclear pore; nucleus. Molecular Function: protein binding; Ran GTPase binding; GTPase inhibitor activity; protein transporter activity. Biological Process: ribosomal protein import into nucleus; viral reproduction; positive regulation of protein import into nucleus; negative regulation of catalytic activity; NLS-bearing substrate import into nucleus

size1 :

48-Strip-Wells

price1 :

470 USD

size2 :

96-Strip-Wells

price2 :

680

size3 :

5x96-Strip-Wells

price3 :

3100

size4 :

10x96-Strip-Wells

price4 :

6095