product summary
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company name :
MyBioSource
product type :
ELISA/assay
product name :
Human Sphingosine Kinase 2 (SPHK2) ELISA Kit
catalog :
MBS9311888
quantity :
48-Strip-Wells
price :
435 USD
more info or order :
MyBioSource product webpage
product information
catalog number :
MBS9311888
products type :
ELISA Kit
products full name :
Human Sphingosine Kinase 2 (SPHK2) ELISA Kit
products short name :
Sphingosine Kinase 2 (SPHK2)
other names :
sphingosine kinase 2 isoform d; Sphingosine kinase 2; sphingosine kinase 2; sphingosine kinase type 2; sphingosine kinase 2
products gene name :
SPHK2
other gene names :
SPHK2; SPHK2; SK 2; SK-2; SPK 2; SPK-2; SK 2; SPK 2
uniprot entry name :
SPHK2_HUMAN
reactivity :
Human
storage stability :
Store all reagents at 2-8 degree C
ncbi gi num :
345197213
ncbi acc num :
NP_001230805.1
ncbi gb acc num :
NM_001243876.1
uniprot acc num :
Q9NRA0
ncbi mol weight :
69,217 Da
ncbi pathways :
Calcium Signaling Pathway (83050); Calcium Signaling Pathway (459); Ceramide Signaling Pathway (138023); Fc Gamma R-mediated Phagocytosis Pathway (114228); Fc Gamma R-mediated Phagocytosis Pathway (106590); IL12-mediated Signaling Events Pathway (137922); Metabolism Pathway (477135); Metabolism Of Lipids And Lipoproteins Pathway (160976); Signal Transduction Of S1P Receptor Pathway (198819); Sphingolipid Metabolism Pathway (760636)
ncbi summary :
This gene encodes one of two sphingosine kinase isozymes that catalyze the phosphorylation of sphingosine into sphingosine 1-phosphate. Sphingosine 1-phosphate mediates many cellular processes including migration, proliferation and apoptosis, and also plays a role in several types of cancer by promoting angiogenesis and tumorigenesis. The encoded protein may play a role in breast cancer proliferation and chemoresistance. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Aug 2011]
uniprot summary :
SPHK2: Catalyzes the phosphorylation of sphingosine to form sphingosine 1-phosphate (SPP), a lipid mediator with both intra- and extracellular functions. Also acts on D-erythro- dihydrosphingosine, D-erythro-sphingosine and L-threo- dihydrosphingosine. Binds phosphoinositides. 3 isoforms of the human protein are produced by alternative splicing. Protein type: Lipid Metabolism - sphingolipid; Kinase, lipid; EC 2.7.1.91. Chromosomal Location of Human Ortholog: 19q13.2. Cellular Component: membrane; lysosomal membrane; cytosol. Molecular Function: D-erythro-sphingosine kinase activity; protein binding; Ras GTPase binding; sphinganine kinase activity; diacylglycerol kinase activity; ATP binding; NAD+ kinase activity. Biological Process: cell proliferation; blood vessel development; sphingolipid metabolic process; sphingolipid biosynthetic process; protein kinase C activation; positive regulation of cell proliferation; sphinganine-1-phosphate biosynthetic process; brain development; sphingosine metabolic process; lipid phosphorylation; negative regulation of apoptosis
size1 :
48-Strip-Wells
price1 :
435 USD
size2 :
96-Strip-Wells
price2 :
600
more info or order :
MyBioSource product webpage
company information
MyBioSource
P.O. Box 153308
San Diego, CA 92195-3308
sales@mybiosource.com
https://www.mybiosource.com
1-888-627-0165
headquarters: USA
MyBioSource, LLC was orginally founded in Vancouver by three enthusiastic scientists who are passionate about providing the world with the best reagents available. Together, they form a company with a big vision known as MyBioSource. MyBioSource is now located in San Diego, California, USA.

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