catalog number :
MBS9310602
products type :
ELISA Kit
products full name :
Pig macrophage inflammatory protein 1alpha, MIP-1alpha ELISA Kit
products short name :
macrophage inflammatory protein 1alpha, MIP-1alpha
products name syn :
Pig macrophage inflammatory protein 1alpha; MIP-1alpha ELISA Kit; macrophage inflammatory protein 1alpha; MIP-1alpha
other names :
macrophage inflammatory protein 1 alpha, partial; C-C motif chemokine 3; C-C motif chemokine 3; SIS-beta; PAT 464.1; G0/G1 switch regulatory protein 19-1; macrophage inflammatory protein 1-alpha; tonsillar lymphocyte LD78 alpha protein; small inducible cytokine A3 (homologous to mouse Mip-1a); chemokine (C-C motif) ligand 3; G0/G1 switch regulatory protein 19-1; Macrophage inflammatory protein 1-alpha; MIP-1-alpha; PAT 464.1; SIS-beta; Small-inducible cytokine A3; Tonsillar lymphocyte LD78 alpha proteinCleaved into the following chain:MIP-1-alpha(4-69)Alternative name(s):LD78-alpha(4-69)
products gene name :
MIP1alpha/CCL3
other gene names :
CCL3; CCL3; MIP1A; SCYA3; G0S19-1; LD78ALPHA; MIP-1-alpha; G0S19-1; MIP1A; SCYA3; MIP-1-alpha
uniprot entry name :
CCL3_HUMAN
ncbi acc num :
AAC03539.1
ncbi mol weight :
10,085 Da
ncbi pathways :
Chagas Disease (American Trypanosomiasis) Pathway 147809!!Chagas Disease (American Trypanosomiasis) Pathway 147795!!Chemokine Receptors Bind Chemokines Pathway 106359!!Chemokine Signaling Pathway 99051!!Chemokine Signaling Pathway 96864!!Class A/1 (Rhodopsin-like Receptors) Pathway 106357!!Cytokine-cytokine Receptor Interaction Pathway 83051!!Cytokine-cytokine Receptor Interaction Pathway 460!!GPCR Ligand Binding Pathway 161020!!IL12-mediated Signaling Events Pathway 137922
ncbi summary :
This locus represents a small inducible cytokine. The encoded protein, also known as macrophage inflammatory protein 1 alpha, plays a role in inflammatory responses through binding to the receptors CCR1, CCR4 and CCR5. Polymorphisms at this locus may be associated with both resistance and susceptibility to infection by human immunodeficiency virus type 1.[provided by RefSeq, Sep 2010]
uniprot summary :
Function: Monokine with inflammatory and chemokinetic properties. Binds to CCR1, CCR4 and CCR5. One of the major HIV-suppressive factors produced by CD8+ T-cells. Recombinant MIP-1-alpha induces a dose-dependent inhibition of different strains of HIV-1, HIV-2, and simian immunodeficiency virus (SIV).1 PublicationManual assertion based on experiment in:Ref.8