This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
MyBioSource
product type :
ELISA/assay
product name :
Rat apoptosis inducing factor, AIF ELISA Kit
catalog :
MBS9309967
quantity :
48-Strip-Wells
price :
435 USD
product information
catalog number :
MBS9309967
products type :
ELISA Kit
products full name :
Rat apoptosis inducing factor, AIF ELISA Kit
products short name :
apoptosis-inducing factor, mitochondrion-associated, 1
products name syn :
Rat apoptosis inducing factor; AIF ELISA Kit; RP3-438D16.2; AIF; MGC111425; PDCD8; programmed cell death 8; programmed cell death 8 (apoptosis-inducing factor) ; striatal apoptosis-inducing factor; apoptosis-inducing factor; mitochondrion-associated; 1
other names :
apoptosis-inducing factor 1, mitochondrial; Apoptosis-inducing factor 1, mitochondrial; apoptosis-inducing factor 1, mitochondrial; programmed cell death protein 8; programmed cell death 8 (apoptosis-inducing factor); apoptosis-inducing factor, mitochondrion-associated 1; Programmed cell death protein 8
products gene name :
AIFM1
other gene names :
Aifm1; Aifm1; Aif; Pdcd8; Aif; Pdcd8
uniprot entry name :
AIFM1_RAT
reactivity :
Rat
storage stability :
Store all reagents at 2-8 degree C
ncbi gi num :
25742626
ncbi acc num :
NP_112646.1
ncbi gb acc num :
NM_031356.1
uniprot acc num :
Q9JM53
ncbi mol weight :
66,723 Da
ncbi pathways :
Apoptosis Pathway (83452); Apoptosis Pathway (470); Apoptosis Modulation By HSP70 Pathway (198484)
ncbi summary :
may facilitate apoptotic chromatin condensation and DNA degradation [RGD, Feb 2006]
uniprot summary :
PDCD8: Probable oxidoreductase that has a dual role in controlling cellular life and death; during apoptosis, it is translocated from the mitochondria to the nucleus to function as a proapoptotic factor in a caspase-independent pathway, while in normal mitochondria, it functions as an antiapoptotic factor via its oxidoreductase activity. The soluble form (AIFsol) found in the nucleus induces parthanatos i.e., caspase-independent fragmentation of chromosomal DNA. Interacts with EIF3G,and thereby inhibits the EIF3 machinery and protein synthesis, and activates casapse-7 to amplify apoptosis. Plays a critical role in caspase- independent, pyknotic cell death in hydrogen peroxide-exposed cells. Binds to DNA in a sequence-independent manner. Interacts with XIAP/BIRC4. Interacts (via N-terminus) with EIF3G (via C-terminus). Belongs to the FAD-dependent oxidoreductase family. 4 isoforms of the human protein are produced by alternative splicing. Protein type: Mitochondrial; EC 1.-.-.-; Oxidoreductase; Apoptosis. Cellular Component: mitochondrion; perinuclear region of cytoplasm; mitochondrial inner membrane; cytoplasm; mitochondrial intermembrane space; nucleus; cytosol. Molecular Function: protein dimerization activity; oxidoreductase activity, acting on NADH or NADPH; DNA binding; NAD(P)H oxidase activity. Biological Process: neuron differentiation; caspase activation; mitochondrial respiratory chain complex I assembly; neuron apoptosis; cell redox homeostasis; apoptosis
size1 :
48-Strip-Wells
price1 :
435 USD
size2 :
96-Strip-Wells
price2 :
600
company information
MyBioSource
P.O. Box 153308
San Diego, CA 92195-3308
sales@mybiosource.com
https://www.mybiosource.com
1-888-627-0165
headquarters: USA
MyBioSource, LLC was orginally founded in Vancouver by three enthusiastic scientists who are passionate about providing the world with the best reagents available. Together, they form a company with a big vision known as MyBioSource. MyBioSource is now located in San Diego, California, USA.

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