catalog number :
MBS9309876
products type :
ELISA Kit
products full name :
Mouse Major Basic Protein (MBP) ELISA Kit
products short name :
[Major Basic Protein (MBP)]
other names :
[major basic protein; Bone marrow proteoglycan; bone marrow proteoglycan; bone-marrow proteoglycan; proteoglycan 2 preproprotein; natural killer cell activator; eosinophil major basic protein; eosinophil granule major basic protein; proteoglycan 2, bone marrow (natural killer cell activator, eosinophil granule major basic protein); Proteoglycan 2Cleaved into the following chain:Eosinophil granule major basic protein; EMBP; MBP; Alternative name(s):; Pregnancy-associated major basic protein]
products gene name :
[BMPG]
products gene name syn :
[PRG2; BMPG; Proteoglycan 2; Bone Marrow,Natural Killer Cell Activator;]
other gene names :
[PRG2; PRG2; MBP; BMPG; MBP1; MBP; BMPG; EMBP; MBP]
uniprot entry name :
PRG2_HUMAN
specificity :
No significant cross-reactivity or interference between this analyte and analogues is observed.
storage stability :
Store all reagents at 2-8 degree C
other info1 :
Assay Type: Sandwich. Detection Range: 0.625 ng/ml - 20 ng/ml. Sensitivity: 0.1 ng/ml.
other info2 :
Intra-assay Precision: Intra-assay CV (%) is less than 15%. Inter-assay Precision: Inter-assay CV (%) is less than 15%. [CV(%) = SD/mean ×100].
products description :
Background/Introduction: This Quantitative Sandwich ELISA kit is only for in vitro research use only, not for drug, household, therapeutic or diagnostic applications! This kit is intended to be used for determination the level of MBP (hereafter termed "analyte") in undiluted original Mouse body fluids, tissue homogenates, secretions or feces samples. This kit is NOT suitable for assaying non-biological sources of substances.
ncbi acc num :
AAA36203.1
ncbi mol weight :
25,206 Da
ncbi pathways :
Asthma Pathway (83120); Asthma Pathway (532)
ncbi summary :
The protein encoded by this gene is the predominant constituent of the crystalline core of the eosinophil granule. High levels of the proform of this protein are also present in placenta and pregnancy serum, where it exists as a complex with several other proteins including pregnancy-associated plasma protein A (PAPPA), angiotensinogen (AGT), and C3dg. This protein may be involved in antiparasitic defense mechanisms as a cytotoxin and helminthotoxin, and in immune hypersensitivity reactions. It is directly implicated in epithelial cell damage, exfoliation, and bronchospasm in allergic diseases. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2011]
uniprot summary :
PRG2: Cytotoxin and helminthotoxin. Also induces non-cytolytic histamine release from human basophils. Involved in antiparasitic defense mechanisms and immune hypersensitivity reactions. The proform acts as a proteinase inhibitor, reducing the activity of PAPPA. Protein type: Secreted, signal peptide; Vesicle; Secreted. Chromosomal Location of Human Ortholog: 11q12. Cellular Component: transport vesicle; extracellular region. Molecular Function: heparin binding; carbohydrate binding. Biological Process: positive regulation of interleukin-4 production; negative regulation of interleukin-10 production; defense response to bacterium; immune response; defense response to nematode
size4 :
10x96-Strip-Wells