catalog number :
MBS9309860
products type :
ELISA Kit
products full name :
Mouse Interleukin 10 Receptor Alpha (IL10Ra) ELISA Kit
products short name :
[Interleukin 10 Receptor Alpha (IL10Ra)]
other names :
[interleukin-10 receptor subunit alpha; Interleukin-10 receptor subunit alpha; interleukin-10 receptor subunit alpha; IL-10RA; IL-10R subunit 1; IL-10R subunit alpha; IL-10 receptor subunit alpha; interleukin-10 receptor subunit 1; interleukin-10 receptor alpha chain; interleukin 10 receptor, alpha; CDw210a; Interleukin-10 receptor subunit 1]
products gene name :
[IL10Ra]
other gene names :
[IL10RA; IL10RA; CD210; IL10R; CD210a; CDW210A; HIL-10R; IL-10R1; IL10R; IL-10 receptor subunit alpha; IL-10R subunit alpha; IL-10RA; IL-10R subunit 1; IL-10R1]
uniprot entry name :
I10R1_HUMAN
specificity :
No significant cross-reactivity or interference between this analyte and analogues is observed.
storage stability :
Store all reagents at 2-8 degree C
other info1 :
Samples: Bovine Body Fluids And Tissue Homogenates. Assay Type: Quantitative Sandwich. Detection Range: 15.6pg/ml-500pg/ml. Sensitivity: 2.0pg/ml.
other info2 :
Intra-assay Precision: Intra-assay CV (%) is less than 15%. Inter-assay Precision: Inter-assay CV (%) is less than 15%. [CV(%) = SD/mean ×100]. All CV% should be compared by concentration, not compared by OD values.
products description :
Background/Introduction: This Quantitative Sandwich ELISA kit is for lab reagent/research use only, not for drug, household, therapeutic or diagnostic applications! This kit is intended to be used for determine the level of IL10RA (hereafter termed "analyte") in undiluted original Bovine body fluids and tissue homogenates. This kit is NOT suitable for assaying non-biological sources of substances.
ncbi acc num :
NP_001549.2
ncbi gb acc num :
NM_001558.3
ncbi mol weight :
63,003 Da
ncbi pathways :
Cytokine-cytokine Receptor Interaction Pathway (83051); Cytokine-cytokine Receptor Interaction Pathway (460); Epstein-Barr Virus Infection Pathway (585562); Epstein-Barr Virus Infection Pathway (587115); Jak-STAT Signaling Pathway (83077); Jak-STAT Signaling Pathway (488); Toxoplasmosis Pathway (169642); Toxoplasmosis Pathway (169493); Tuberculosis Pathway (213780); Tuberculosis Pathway (213743)
ncbi summary :
The protein encoded by this gene is a receptor for interleukin 10. This protein is structurally related to interferon receptors. It has been shown to mediate the immunosuppressive signal of interleukin 10, and thus inhibits the synthesis of proinflammatory cytokines. This receptor is reported to promote survival of progenitor myeloid cells through the insulin receptor substrate-2/PI 3-kinase/AKT pathway. Activation of this receptor leads to tyrosine phosphorylation of JAK1 and TYK2 kinases. Two transcript variants, one protein-coding and the other not protein-coding, have been found for this gene. [provided by RefSeq, Jan 2009]
uniprot summary :
IL10RA: a receptor for interleukin 10 structurally related to interferon receptors. Mediates the immunosuppressive signal of interleukin 10, and thus inhibits the synthesis of proinflammatory cytokines. This receptor is reported to promote survival of progenitor myeloid cells through the insulin receptor substrate-2/PI 3-kinase/AKT pathway. Activation of this receptor leads to tyrosine phosphorylation of JAK1 and TYK2 kinases. Protein type: Membrane protein, integral; Receptor, cytokine. Chromosomal Location of Human Ortholog: 11q23. Cellular Component: integral to membrane; plasma membrane. Molecular Function: signal transducer activity; interleukin-10 binding; protein binding; interleukin-10 receptor activity; receptor activity. Biological Process: cytokine and chemokine mediated signaling pathway; response to lipopolysaccharide. Disease: Inflammatory Bowel Disease 28, Autosomal Recessive
size4 :
10x96-Strip-Wells