Human Integrin alpha-1, ITGA1 ELISA Kit | MyBioSource MBS930698 product information

product summary

company name :

MyBioSource

product type :

ELISA/assay

product name :

Human Integrin alpha-1, ITGA1 ELISA Kit

catalog :

MBS930698

quantity :

48-Strip-Wells

price :

510 USD

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS930698

products type :

ELISA Kit

products full name :

Human Integrin alpha-1, ITGA1 ELISA Kit

products short name :

integrin, alpha 1

products name syn :

Human Integrin alpha-1 (ITGA1) ELISA kit; CD49a; VLA1; laminin and collagen receptor; very late activation protein 1; integrin; alpha 1

other names :

integrin alpha-1; Integrin alpha-1; integrin alpha-1; VLA-1; laminin and collagen receptor; very late activation protein 1; CD49 antigen-like family member A; integrin, alpha 1; CD49 antigen-like family member A; Laminin and collagen receptor; VLA-1; CD_antigen: CD49a

products gene name :

ITGA1

other gene names :

ITGA1; ITGA1; VLA1; CD49a

uniprot entry name :

ITA1_HUMAN

reactivity :

Human

sequence length :

1179

specificity :

This assay has high sensitivity and excellent specificity for detection of Human ITGA1. No significant cross-reactivity or interference between Human ITGA1 and analogues was observed.

storage stability :

Unopened test kits should be stored at 2 to 8 degree C upon receipt. Please refer to pdf manual for further storage instructions.

other info1 :

Samples: Serum, plasma, tissue homogenates. Assay Type: Sandwich. Detection Range: 0.312 ng/ml-20 ng/ml. Sensitivity: 0.078 ng/ml

other info2 :

Intra-assay Precision: Intra-assay Precision (Precision within an assay): CV% is less than 8%. Three samples of known concentration were tested twenty times on one plate to assess. Inter-assay Precision (Precision between assays): CV% is less than 10%. Three samples of known concentration were tested in twenty assays to assess. Detection Wavelength: 450 nm. Sample Volume: 50-100ul. Protein Biological Process 1: Cell Adhesion. Protein Biological Process 3: Cell adhesion

products description :

Principle of the Assay: This assay employs the quantitative sandwich enzyme immunoassay technique. Antibody specific for ITGA1 has been pre-coated onto a microplate. Standards and samples are pipetted into the wells and any ITGA1 present is bound by the immobilized antibody. After removing any unbound substances, a biotin-conjugated antibody specific for ITGA1 is added to the wells. After washing, avidin conjugated Horseradish Peroxidase (HRP) is added to the wells. Following a wash to remove any unbound avidin-enzyme reagent, a substrate solution is added to the wells and color develops in proportion to the amount of ITGA1 bound in the initial step. The color development is stopped and the intensity of the color is measured.

ncbi gi num :

31657142

ncbi acc num :

NP_852478.1

ncbi gb acc num :

NM_181501.1

uniprot acc num :

P56199

ncbi mol weight :

130,848 Da

ncbi pathways :

Arf6 Trafficking Events Pathway (137954); Arrhythmogenic Right Ventricular Cardiomyopathy Pathway (672454); Arrhythmogenic Right Ventricular Cardiomyopathy (ARVC) Pathway (117293); Arrhythmogenic Right Ventricular Cardiomyopathy (ARVC) Pathway (116129); Axon Guidance Pathway (105688); CHL1 Interactions Pathway (161007); CXCR4-mediated Signaling Events Pathway (137910); Developmental Biology Pathway (477129); Dilated Cardiomyopathy Pathway (121494); Dilated Cardiomyopathy Pathway (121285)

ncbi summary :

This gene encodes the alpha 1 subunit of integrin receptors. This protein heterodimerizes with the beta 1 subunit to form a cell-surface receptor for collagen and laminin. The heterodimeric receptor is involved in cell-cell adhesion and may play a role in inflammation and fibrosis. The alpha 1 subunit contains an inserted (I) von Willebrand factor type I domain which is thought to be involved in collagen binding. [provided by RefSeq, Jul 2008]

uniprot summary :

ITGA1: Integrin alpha-1/beta-1 is a receptor for laminin and collagen. It recognizes the proline-hydroxylated sequence G-F-P-G- E-R in collagen. Belongs to the integrin alpha chain family. Protein type: Membrane protein, integral; Motility/polarity/chemotaxis; Cell adhesion. Chromosomal Location of Human Ortholog: 5q11.2. Cellular Component: neuron projection; focal adhesion; cell surface; membrane; acrosome; plasma membrane; perikaryon; integrin complex; lipid raft; external side of plasma membrane. Molecular Function: collagen binding; protein binding; metal ion binding; protein phosphatase binding; receptor binding. Biological Process: negative regulation of epidermal growth factor receptor signaling pathway; positive regulation of phosphoprotein phosphatase activity; integrin-mediated signaling pathway; axon guidance; neutrophil chemotaxis; extracellular matrix organization and biogenesis; activation of MAPK activity; cell-matrix adhesion; vasodilation; negative regulation of cell proliferation; muscle contraction; cellular extravasation; positive regulation of neuron apoptosis; blood coagulation

size1 :

48-Strip-Wells

price1 :

510 USD

size2 :

96-Strip-Wells

price2 :

725

size3 :

5x96-Strip-Wells

price3 :

2565

size4 :

10x96-Strip-Wells

price4 :

4800

more info or order :

MyBioSource product webpage