ELISA/assay

Rat ATP-sensitive inward rectifier potassium channel 10, KCNJ10/Kir4.1 ELISA Kit

MBS9306459

48-Strip-Wells

435 USD

ELISA Kit

Rat ATP-sensitive inward rectifier potassium channel 10, KCNJ10/Kir4.1 ELISA Kit

ATP-sensitive inward rectifier potassium channel 10, KCNJ10/Kir4.1

ATP-sensitive inward rectifier potassium channel 10; ATP-sensitive inward rectifier potassium channel 10; ATP-sensitive inward rectifier potassium channel 10; inward rectifier K+ channel KIR1.2; inward rectifier K(+) channel Kir1.2; ATP-dependent inwardly rectifying potassium channel Kir4.1; potassium channel, inwardly rectifying subfamily J member 10; glial ATP-dependent inwardly rectifying potassium channel KIR4.1; potassium inwardly-rectifying channel, subfamily J, member 10; ATP-dependent inwardly rectifying potassium channel Kir4.1; Inward rectifier K(+) channel Kir1.2; Potassium channel, inwardly rectifying subfamily J member 10

KCNJ10/Kir4.1

KCNJ10; KCNJ10; KIR1.2; KIR4.1; SESAME; BIRK-10; KCNJ13-PEN

IRK10_HUMAN

Rat

No significant cross-reactivity or interference between this analyte and analogues is observed.

Store all reagents at 2-8 degree C

Samples: Rat body fluids, tissue homogenates, secretions or feces samples. This kit is NOT suitable for assaying non-biological sources of substances. Assay Type: Sandwich. Detection Range: 0.5 ng/ml - 16 ng/ml. Sensitivity: 0.1 ng/ml

Intra-assay Precision: Intra-assay CV (%) is less than 15%. Inter-assay Precision: Inter-assay CV (%) is less than 15%. [CV(%) = SD/mean ×100].

Background/Introduction: This Quantitative Sandwich ELISA kit is only for in vitro research use only, NOT for drug, household, therapeutic or diagnostic applications! This kit is intended to be used for determination the level of KCNJ10 (hereafter termed "analyte") in undiluted original Rat body fluids, tissue homogenates, secretions or feces samples. This k it i s NOT suitable for assaying non-biological sources of substances.

25121966

NP_002232.2

NM_002241.4

P78508

42,508 Da

Activation Of G Protein Gated Potassium Channels Pathway (366226); Activation Of GABAB Receptors Pathway (187181); G Protein Gated Potassium Channels Pathway (366225); GABA B Receptor Activation Pathway (187180); GABA Receptor Activation Pathway (187178); Gastric Acid Secretion Pathway (154409); Gastric Acid Secretion Pathway (154383); Inhibition Of Voltage Gated Ca2+ Channels Via Gbeta/gamma Subunits Pathway (187183); Inwardly Rectifying K+ Channels Pathway (366224); Neuronal System Pathway (106513)

This gene encodes a member of the inward rectifier-type potassium channel family, characterized by having a greater tendency to allow potassium to flow into, rather than out of, a cell. The encoded protein may form a heterodimer with another potassium channel protein and may be responsible for the potassium buffering action of glial cells in the brain. Mutations in this gene have been associated with seizure susceptibility of common idiopathic generalized epilepsy syndromes. [provided by RefSeq, Jul 2008]

Kir4.1: May be responsible for potassium buffering action of glial cells in the brain. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. Can be blocked by extracellular barium and cesium. Defects in KCNJ10 are the cause of seizures, sensorineural deafness, ataxia, mental retardation, and electrolyte imbalance (SESAMES). A complex disorder characterized by generalized seizures with onset in infancy, delayed psychomotor development, ataxia, sensorineural hearing loss, hypokalemia, metabolic alkalosis, and hypomagnesemia. Belongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family. KCNJ10 subfamily. Protein type: Channel, potassium; Membrane protein, multi-pass; Membrane protein, integral; Channel, ligand-gated. Chromosomal Location of Human Ortholog: 1q23.2. Cellular Component: microvillus; basolateral plasma membrane; integral to plasma membrane; apical plasma membrane; plasma membrane. Molecular Function: identical protein binding; protein binding; ATP-activated inward rectifier potassium channel activity; ATP binding; receptor binding. Biological Process: regulation of long-term neuronal synaptic plasticity; myelination in the central nervous system; membrane hyperpolarization; response to glucocorticoid stimulus; response to blue light; glutamate uptake during transmission of nerve impulse; response to mineralocorticoid stimulus; adult walking behavior; protein homotetramerization; synaptic transmission; visual perception; potassium ion import; optic nerve development; regulation of resting membrane potential; regulation of sensory perception of pain; inflammatory response; potassium ion homeostasis; potassium ion transport. Disease: Pendred Syndrome; Seizures, Sensorineural Deafness, Ataxia, Mental Retardation, And Electrolyte Imbalance; Deafness, Autosomal Recessive 4, With Enlarged Vestibular Aqueduct

48-Strip-Wells

435 USD

96-Strip-Wells

600