Human Arginine decarboxylase, ADC ELISA Kit | MyBioSource MBS9306049 product information

product summary

company name :

MyBioSource

product type :

ELISA/assay

product name :

Human Arginine decarboxylase, ADC ELISA Kit

catalog :

MBS9306049

quantity :

48-Strip-Wells

price :

470 USD

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS9306049

products type :

ELISA Kit

products full name :

Human Arginine decarboxylase, ADC ELISA Kit

products short name :

[Arginine decarboxylase, ADC]

other names :

[arginine decarboxylase; Arginine decarboxylase; arginine decarboxylase; ARGDC; ODC-paralogue; antizyme inhibitor 2; ODC antizyme inhibitor-2; ornithine decarboxylase like; ornithine decarboxylase-paralog; ornithine decarboxylase-like protein; arginine decarboxylase; ODC-paralogue; ODC-p; Ornithine decarboxylase-like protein]

products gene name :

[ADC]

other gene names :

[ADC; ADC; AZI2; ODC-p; ODC1L; KIAA1945; ODCP; ADC; ARGDC; ODC-p]

uniprot entry name :

ADC_HUMAN

reactivity :

Human

specificity :

No significant cross-reactivity or interference between this analyte and analogues is observed.

storage stability :

Store all reagents at 2-8 degree C

other info1 :

Samples: Undiluted original Human body fluids, tissue homogenates, secretions or feces samples. This kit is NOT suitable for assaying non-biological sources of substances. Assay Type: Sandwich. Detection Range: 0.625 ng/ml - 20 ng/ml. Sensitivity: 0.1 ng/ml.

other info2 :

Intra-assay Precision: Intra-assay CV (%) is less than 15%. Inter-assay Precision: Inter-assay CV (%) is less than 15%. [CV(%) = SD/mean ×100].

products description :

Background/Introduction: This Quantitative Sandwich ELISA kit is only for in vitro research use only, NOT for drug, household, therapeutic or diagnostic applications! This kit is intended to be used for determination the level of ADC (hereafter termed "analyte") in undiluted original Human body fluids, tissue homogenates, secretions or feces samples. This kit is NOT suitable for assaying non-biological sources of substances.

ncbi gi num :

16506287

ncbi acc num :

NP_443724.1

ncbi gb acc num :

NM_052998.2

uniprot acc num :

Q96A70

ncbi mol weight :

49,980 Da

ncbi pathways :

Agmatine Biosynthesis Pathway (106194); Arginine And Proline Metabolism Pathway (82957); Arginine And Proline Metabolism Pathway (323); Metabolism Pathway (477135); Metabolism Of Amino Acids And Derivatives Pathway (106169); Metabolism Of Polyamines Pathway (106193); Polyamine Biosynthesis, Arginine = Agmatine = Putrescine = Spermidine Pathway (413402); Polyamine Biosynthesis, Arginine = Agmatine = Putrescine = Spermidine Pathway (468310); Putrescine Biosynthesis III Pathway (142303)

ncbi summary :

The protein encoded by this gene belongs to the antizyme inhibitor family, which plays a role in cell growth and proliferation by maintaining polyamine homeostasis within the cell. Antizyme inhibitors are homologs of ornithine decarboxylase (ODC, the key enzyme in polyamine biosynthesis) that have lost the ability to decarboxylase ornithine; however, retain the ability to bind to antizymes. Antizymes negatively regulate intracellular polyamine levels by binding to ODC and targeting it for degradation, as well as by inhibiting polyamine uptake. Antizyme inhibitors function as positive regulators of polyamine levels by sequestering antizymes and neutralizing their effect. This gene encodes antizyme inhibitor 2, the second member of this gene family. Like antizyme inhibitor 1, antizyme inhibitor 2 interacts with all 3 antizymes and stimulates ODC activity and polyamine uptake. However, unlike antizyme inhibitor 1, which is ubiquitously expressed and localized in the nucleus and cytoplasm, antizyme inhibitor 2 is predominantly expressed in the brain and testis and localized in the endoplasmic reticulum-golgi intermediate compartment. Recent studies indicate that antizyme inhibitor 2 is also expressed in specific cell types in ovaries, adrenal glands and pancreas, and in mast cells. The exact function of this gene is not known, however, available data suggest its role in cell growth, spermiogenesis, vesicular trafficking and secretion. Accumulation of antizyme inhibitor 2 has also been observed in brains of patients with Alzheimer's disease. There has been confusion in literature and databases over the nomenclature of this gene, stemming from an earlier report that a human cDNA clone (identical to ODCp/AZIN2) had arginine decarboxylase (ADC) activity (PMID:14738999). Subsequent studies in human and mouse showed that antizyme inhibitor 2 was devoid of arginine decarboxylase activity (PMID:19956990). Alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, Sep 2014]

uniprot summary :

ADC: Decarboxylates L-arginine to agmatine. Truncated splice isoforms probably lack activity. Belongs to the Orn/Lys/Arg decarboxylase class-II family. 5 isoforms of the human protein are produced by alternative splicing. Protein type: Lyase; EC 4.1.1.19; Amino Acid Metabolism - arginine and proline; Mitochondrial. Chromosomal Location of Human Ortholog: 1p35.1. Cellular Component: transport vesicle; ER-Golgi intermediate compartment membrane; cis-Golgi network; mitochondrion; axon; perinuclear region of cytoplasm; dendrite; perikaryon; trans-Golgi network; cytoplasmic vesicle; nucleus; cytosol. Molecular Function: protein binding; putrescine transmembrane transporter activity; ornithine decarboxylase activator activity; catalytic activity. Biological Process: positive regulation of catalytic activity; polyamine biosynthetic process; ornithine metabolic process; spermatogenesis; negative regulation of protein catabolic process; putrescine transport; polyamine metabolic process

size1 :

48-Strip-Wells

price1 :

470 USD

size2 :

96-Strip-Wells

price2 :

680

size3 :

5x96-Strip-Wells

price3 :

3100

size4 :

10x96-Strip-Wells

price4 :

6095

more info or order :

MyBioSource product webpage