catalog number :
MBS9305489
products type :
ELISA Kit
products full name :
Mouse Sialidase-1, NEU1 ELISA Kit
products short name :
[Sialidase-1, NEU1]
other names :
[sialidase-1; Sialidase-1; sialidase-1; sialidase 1; G9 sialidase; lysosomal sialidase; HLA-B-associated transcript 7; N-acetyl-alpha-neuraminidase 1; neuraminidase 1; G9 sialidase; Lysosomal sialidase; N-acetyl-alpha-neuraminidase 1]
products gene name :
[NEU1]
other gene names :
[Neu1; Neu1; G9; Apl; Neu; Aglp; Bat7; Bat-7; Map-2; Neu-1; AA407268; AA407316; Neu]
uniprot entry name :
NEUR1_MOUSE
specificity :
No significant cross-reactivity or interference between this analyte and analogues is observed.
storage stability :
Store all reagents at 2-8 degree C
other info1 :
Samples: Mouse body fluids, tissue homogenates, secretions or feces samples. This kit is NOT suitable for assaying non-biological sources of substances. Assay Type: Sandwich. Detection Range: 0.625 ng/ml - 20 ng/ml. Sensitivity: 0.1 ng/ml
other info2 :
Intra-assay Precision: Intra-assay CV (%) is less than 15%. Inter-assay Precision: Inter-assay CV (%) is less than 15%. [CV(%) = SD/mean ×100].
products description :
Background/Introduction: This Quantitative Sandwich ELISA kit is only for in vitro research use only, NOT for drug, household, therapeutic or diagnostic applications! This kit is intended to be used for determination the level of NEU1 (hereafter termed "analyte") in undiluted original Mouse body fluids, tissue homogenates, secretions or feces samples. This kit is NOT suitable for assaying non-biological sources of substances.
ncbi acc num :
NP_035023.3
ncbi gb acc num :
NM_010893.3
ncbi mol weight :
44,591 Da
uniprot summary :
NEU1: Catalyzes the removal of sialic acid (N-acetylneuramic acid) moities from glycoproteins and glycolipids. To be active, it is strictly dependent on its presence in the multienzyme complex. Appears to have a preference for alpha 2-3 and alpha 2-6 sialyl linkage. Defects in NEU1 are the cause of sialidosis (SIALIDOSIS). It is a lysosomal storage disease occurring as two types with various manifestations. Type 1 sialidosis (cherry red spot-myoclonus syndrome or normosomatic type) is late-onset and it is characterized by the formation of cherry red macular spots in childhood, progressive debilitating myoclonus, insiduous visual loss and rarely ataxia. The diagnosis can be confirmed by the screening of the urine for sialyloligosaccharides. Type 2 sialidosis (also known as dysmorphic type) occurs as several variants of increasing severity with earlier age of onset. It is characterized by the presence of abnormal somatic features including coarse facies and dysostosis multiplex, vertebral deformities, mental retardation, cherry-red spot/myoclonus, sialuria, cytoplasmic vacuolation of peripheral lymphocytes, bone marrow cells and conjunctival epithelial cells. Belongs to the glycosyl hydrolase 33 family. Protein type: EC 3.2.1.18; Lipid Metabolism - sphingolipid; Motility/polarity/chemotaxis; Hydrolase; Glycan Metabolism - other glycan degradation. Cellular Component: cell surface; intracellular membrane-bound organelle; membrane; lysosome; plasma membrane; cytoplasmic vesicle; cell junction. Molecular Function: protein binding; hydrolase activity; hydrolase activity, acting on glycosyl bonds; exo-alpha-sialidase activity. Biological Process: oligosaccharide catabolic process; metabolic process; carbohydrate metabolic process; lipid metabolic process; lipid catabolic process
size4 :
10x96-Strip-Wells